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    Salvinorin A Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 2 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 19 combo interactions documented
    • PubChem toxicity data

    Summary PsychonautWiki

    Salvinorin A is the main active psychoactive molecule within Salvia Divinorum, a Mexican plant which has a long history of use as an entheogen by indigenous Mazatec shamans. It is structurally distinct from other naturally occurring hallucinogens (such as DMT, psilocin and mescaline) because it contains no nitrogen atoms, making it a terpenoid and not an alkaloid as is the norm. This means it cannot be rendered as a salt.

    Dose Information PsychonautWiki Erowid

    ROA Light Common Strong Heavy
    Smoked 200-500µg 500-1000µg 1000-1500µg 1500µg+
    Light Common Strong Heavy

    Onset, Duration & After-effects PsychonautWiki Erowid

    Effect Profile

    3 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 6.5
    Strong 6/10

    Strong visuals with moderate headspace, mild auditory effects and body load

    Visual Intensity ×3
    8
    color enhancement drifting tracers pattern recognition enhancement visual distortions
    Headspace Depth ×3
    6
    conceptual thinking introspection time distortion confusion
    Auditory Effects ×1
    4
    auditory distortion
    Body Load / Somatic Effects ×1
    4
    nausea increased heart rate

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Half tolerance 7d Baseline ~14d

    Formal human tolerance data are lacking. Summaries and user reports suggest minimal acute tolerance; some anecdotal ‘reverse tolerance’/sensitization claims exist but are unverified. Avoid escalating doses rapidly; if reattempting, wait at least a day and reassess mindset and setting.

    Effects Erowid

    Aggregated from 3 Erowid experience reports

    Positive Effects 0

    Adverse Effects 1

    Anxiety 100.0% 70%

    Combinations TripSit

    Cross-Check Salvinorin A with another substance

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.

    Erowid 2 reports 2 neutral visit
    Salvinorin A Journeys neutral exp #77010

    Citation: Gwyllm. 'Salvinorin A Journeys'. The Entheogen Review . Winter Solstice 1998;7(4):90-2. ~1.00-1.25 mg salvinorin A. Ingested with tin foil/straw/lighter method. Immediate and strong effects. Mouth quickly dries, I have never had this experience with salvinorin A before.

    Gwyllm · 1.0 mg smoked / 1.25 mg smoked / 1.5 mg smoked
    I Smoked a High Dose in an MRI Machine neutral exp #118585

    Smoking Salvia in an MRI Machine This is my experience report of when I smoked a high dose of FDA approved, pure Salvinorin-A, as a research participant in a Salvia study at Johns Hopkins University.

    Christopher S. · 1 mg smoked

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