Salvinorin B methoxymethyl ether
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- partial dose data
- duration data present
- 19 combo interactions documented
- 2 corroborating sources
- partial dose data
- duration data present
- 19 combo interactions documented
Summary
Salvinorin B methoxymethyl ether (2-O-methoxymethylsalvinorin B, or 2-MMSB) is a semi-synthetic analogue of the natural product Salvinorin A which is used in scientific research. It has a longer duration of action of around 2–3 hours, compared to less than 30 minutes for salvinorin A, and has increased affinity and potency at the κ-opioid receptor. Like the related compound herkinorin, salvinorin B methoxymethyl ether is made from salvinorin B, which is most conveniently made from salvinorin A by deacetylation, as while both salvinorin A and salvinorin B are found in the plant Salvia divinorum, salvinorin A is present in larger quantities.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Smoked | - | - | 275-425µg | 425µg+ |
Onset, Duration & After-effects
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong visuals with moderate headspace, mild auditory effects and body load
Moderate euphoria with mild itching/nausea, low sedation
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
- Stimulation
- Physical euphoria
- Nausea
- Increased heart rate
- Pupil dilation
- Insomnia
- Restlessness
- Dilated pupils
- Sedation
- Spontaneous bodily sensations
- Introspection
- Euphoria
- Conceptual thinking
- Analysis enhancement
- Anxiety
- Memory suppression
- Confusion
- Motor control loss
- Amnesia
- Time distortion
- Color enhancement
- Tracers
- Increased music appreciation
- Tactile enhancement
- Enhanced tactile sensation
- Pattern recognition enhancement
- Disinhibition
- Visual distortions
- Auditory distortion
- Drifting
Combinations
Cross-Check Salvinorin B methoxymethyl ether with another substanceHelpful Links
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