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    Salvinorin B methoxymethyl ether

    Psychedelic Opioid

    Summary PsychonautWiki

    Salvinorin B methoxymethyl ether (2-O-methoxymethylsalvinorin B, or 2-MMSB) is a semi-synthetic analogue of the natural product Salvinorin A which is used in scientific research. It has a longer duration of action of around 2–3 hours, compared to less than 30 minutes for salvinorin A, and has increased affinity and potency at the κ-opioid receptor. Like the related compound herkinorin, salvinorin B methoxymethyl ether is made from salvinorin B, which is most conveniently made from salvinorin A by deacetylation, as while both salvinorin A and salvinorin B are found in the plant Salvia divinorum, salvinorin A is present in larger quantities.

    Dose Information PsychonautWiki

    ROA Light Common Strong Heavy
    Smoked - - 275-425µg+ -
    Light Common Strong Heavy

    Onset, Duration & After-effects PsychonautWiki

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 6.5
    Strong 6/10

    Strong visuals with moderate headspace, mild auditory effects and body load

    Visual Intensity ×3
    8
    color enhancement drifting tracers pattern recognition enhancement visual distortions
    Headspace Depth ×3
    6
    conceptual thinking introspection time distortion confusion
    Auditory Effects ×1
    4
    auditory distortion
    ⚠ Body Load / Somatic Effects ×1
    4
    nausea increased heart rate
    Opioid 3.9
    Moderate 4/10

    Moderate euphoria with mild itching/nausea, low sedation

    Euphoria / Warmth ×3
    6
    physical euphoria euphoria
    Analgesia ×2
    0
    Sedation / Relaxation ×1
    3
    sedation
    ⚠ Itching / Nausea ×1
    4
    nausea
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Salvinorin B methoxymethyl ether
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 1d Half tolerance 21d Baseline ~35d

    Effects

    Positive
    • Stimulation
    • Physical euphoria
    Negative
    • Nausea
    • Increased heart rate
    • Pupil dilation
    • Insomnia
    • Restlessness
    Neutral
    • Dilated pupils
    • Sedation
    • Spontaneous bodily sensations
    Positive
    • Introspection
    • Euphoria
    • Conceptual thinking
    • Analysis enhancement
    Negative
    • Anxiety
    • Memory suppression
    • Confusion
    • Motor control loss
    • Amnesia
    Neutral
    • Time distortion
    Positive
    • Color enhancement
    • Tracers
    • Increased music appreciation
    • Tactile enhancement
    • Enhanced tactile sensation
    • Pattern recognition enhancement
    Negative
    • Disinhibition
    Neutral
    • Visual distortions
    • Auditory distortion
    • Drifting

    Combinations TripSit

    Salvinorin B methoxymethyl ether's nerd page Pharmacology, chemical data, effect profiles, and more
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