Summary
Salvinorin B methoxymethyl ether (2-O-methoxymethylsalvinorin B, or 2-MMSB) is a semi-synthetic analogue of the natural product Salvinorin A which is used in scientific research. It has a longer duration of action of around 2–3 hours, compared to less than 30 minutes for salvinorin A, and has increased affinity and potency at the κ-opioid receptor. Like the related compound herkinorin, salvinorin B methoxymethyl ether is made from salvinorin B, which is most conveniently made from salvinorin A by deacetylation, as while both salvinorin A and salvinorin B are found in the plant Salvia divinorum, salvinorin A is present in larger quantities.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Smoked | - | - | 275-425µg+ | - |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Total |
|---|---|
| Smoked | 3 hrs |
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Effects
Positive
- Stimulation
- Physical euphoria
Negative
- Nausea
- Increased heart rate
- Pupil dilation
- Insomnia
- Restlessness
- Dilated pupils
- Sedation
- Spontaneous bodily sensations
Positive
- Introspection
- Euphoria
- Conceptual thinking
- Analysis enhancement
Negative
- Anxiety
- Memory suppression
- Confusion
- Motor control loss
- Amnesia
- Time distortion
Positive
- Color enhancement
- Tracers
- Increased music appreciation
- Tactile enhancement
- Enhanced tactile sensation
- Pattern recognition enhancement
Negative
- Disinhibition
- Visual distortions
- Auditory distortion
- Drifting