SAM-e
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- PubChem toxicity data
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- PubChem toxicity data
Aliases: Adomet, Ademetionine, S-adenosyl methionine
Summary
S-Adenosyl-L-methionine (also called S-Adenosyl methionine, Ademethionine and commonly as SAMe and SAM-e) is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation in biological organisms. SAMe is an amino acid methionine bound to an ATP molecule that circulates in the blood naturally and acts as a 'methyl donor'. A methyl group in chemistry is simply a carbon molecule (bound to some hydrogens), and donating a methyl group to other molecules can accelerate or preserve reactions in the body as a form of metabolic 'maintenance'.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 400-800mg | 800-1200mg | 1200-1600mg | 1600mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 1.67-3 hrs | 4-6 hrs | 2-4 hrs | 7.67-13 hrs |
Import into PsychonautWiki Journal
The PsychonautWiki Journal app includes SAM-e, but its built-in data can be thinner than ours. Importing this file adds a separate "SAM-e (Substance Search)" custom substance with our dose ranges, durations and tolerance, so you can log against whichever you prefer.
Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
- Stimulation
- Pain Relief
- Stamina Enhancement
- Subtle Stimulation
- Headaches
- Headache
- Fatigue
- Teeth grinding
- Gastrointestinal Distress
- Body odor alteration
- Motivation Enhancement
- Memory Enhancement
- Cognitive Euphoria
- Analysis Enhancement
- Thought Connectivity
- Anxiety Suppression
- Focus Enhancement
- Wakefulness
- Dream Potentiation
- Thought Organization
- Bodily Control Enhancement
- Visual Acuity Enhancement
- Acuity Enhancement
- Auditory Acuity Enhancement
- Color Enhancement
- Appetite Suppression
- Light sensitivity
- Dehydration
- Olfactory Intensification
Helpful Links
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