Summary
S-Adenosyl-L-methionine (also called S-Adenosyl methionine, Ademethionine and commonly as SAMe and SAM-e) is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation in biological organisms. SAMe is an amino acid methionine bound to an ATP molecule that circulates in the blood naturally and acts as a 'methyl donor'. A methyl group in chemistry is simply a carbon molecule (bound to some hydrogens), and donating a methyl group to other molecules can accelerate or preserve reactions in the body as a form of metabolic 'maintenance'.[citation needed].
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 400-800mg | 800-1200mg | 1200-1600mg | 1600mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Oral | 1.67-3 hrs | 4-6 hrs | 2-4 hrs | 24 hrs |
Tolerance
Build-up
varies by mechanism; therapeutic tolerance may develop over weeks of regular use
Reset
typically days to weeks after discontinuation
Effects
Positive
- Stimulation
- Pain Relief
- Stamina Enhancement
- Subtle Stimulation
Negative
- Headaches
- Headache
- Fatigue
- Teeth grinding
- Gastrointestinal Distress
- Body odor alteration
Positive
- Motivation Enhancement
- Memory Enhancement
- Cognitive Euphoria
- Analysis Enhancement
- Thought Connectivity
- Anxiety Suppression
- Focus Enhancement
- Wakefulness
- Dream Potentiation
Negative
- Thought Organization
Positive
- Bodily Control Enhancement
- Visual Acuity Enhancement
- Acuity Enhancement
- Auditory Acuity Enhancement
- Color Enhancement
Negative
- Appetite Suppression
- Light sensitivity
- Appetite suppression
- Dehydration
- Olfactory Intensification