Summary
Sold exclusively as a research chemical with no clinical trials in humans. Despite biased agonist properties in vitro, behaves more like a traditional opioid in vivo with respiratory depression at higher doses. Anecdotal reports describe slow onset (1-3 hours to peak), long duration (effects persisting 12-24 hours), and high potency. Naloxone reverses respiratory depression in animal models but human safety margins remain unverified. Very dangerous to redose before full onset.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 30-90 min | 1-2 hrs | 3-6 hrs | 4-8 hrs | 6-12 hrs |
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Effects
Positive
- Pain relief
- Physical euphoria
- Muscle relaxation
- Stimulation
Negative
- Respiratory depression
- Nausea
- Pupil dilation
- Sedation
- Itchiness
- Pupil constriction
Positive
- Cognitive euphoria
- Reduced anxiety
- Wakefulness
- Focus enhancement
- Motivation enhancement
- Euphoria
Negative
- Constipation
- Compulsive redosing
- Anxiety
- Cognitive fatigue
Positive
- Tactile enhancement
- Color enhancement
- Increased music appreciation
Negative
- Appetite suppression
- Light sensitivity
- Disinhibition
- Dulled perception
- Increased sexuality
- Visual and auditory hallucinations
- Drifting