SR-14968
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Summary
Sold exclusively as a research chemical with no clinical trials in humans. Despite biased agonist properties in vitro, behaves more like a traditional opioid in vivo with respiratory depression at higher doses. Anecdotal reports describe slow onset (1-3 hours to peak), long duration (effects persisting 12-24 hours), and high potency.
Dose Information
Dose basis. The dose figures on this page are not clinical data. They are aggregated from community reports by a secondary source whose own notes state there is no human pharmacokinetic study behind them, and our internal audit flags this substance's dosing as unverifiable. Treat them as a rough orientation, not a safe range. Assume full respiratory depression, keep naloxone to hand, never dose alone, and never combine with benzodiazepines, alcohol or other depressants.
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 25-75mg | 75-150mg | 150-250mg | 250mg+ |
| Sublingual | 5-10mg | 10-25mg | 25-50mg | 50mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 30-90 min | 1-2 hrs | 3-6 hrs | 4-8 hrs | 8.5-17.5 hrs |
| Sublingual | 0.5-4 hrs | - | 2-6 hrs | 3-6 hrs | 6-12 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria with moderate itching/nausea, mild sedation and pain relief
Add to PsychonautWiki Journal
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SR-14968 Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 15-25 Β· light 25-75 Β· common 75-150 Β· strong 150-250 Β· heavy 250+ Sublingual dose (mg): threshold 3-5 Β· light 5-10 Β· common 10-25 Β· strong 25-50 Β· heavy 50+ Oral duration: onset 0.5-1.5h Β· come-up 1-2h Β· peak 3-6h Β· offset 4-8h Β· total 8.5-17.5h Β· after-effects 6-12h Sublingual duration: onset 0.5-4h Β· peak 2-6h Β· offset 3-6h Β· total 6-12h Β· after-effects 12-24h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 112.5 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session β the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Evidence on biased ΞΌ-agonists is mixed: some rodent work shows reduced tolerance development vs. classical opioids, but dependence and withdrawal are still observed. Treat as an opioid with meaningful crossβtolerance and dependence risks.
Cross-Tolerances
Effects
- Pain relief
- Physical euphoria
- Muscle relaxation
- Stimulation
- Respiratory depression
- Nausea
- Sedation
- Itchiness
- Pupil constriction
- Cognitive euphoria
- Reduced anxiety
- Wakefulness
- Focus enhancement
- Motivation enhancement
- Euphoria
- Constipation
- Compulsive redosing
- Anxiety
- Cognitive fatigue
- Tactile enhancement
- Color enhancement
- Increased music appreciation
- Appetite suppression
- Light sensitivity
- Disinhibition
- Dulled perception
- Increased sexuality
- Visual and auditory hallucinations
- Drifting
Combinations
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