Summary
STS-135 (also called N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide or 5F-APICA) is a drug that acts as a potent agonist for the cannabinoid receptors which produces subjective effects somewhat similar to that of cannabis with a short duration and an emphasis on intense physical sensations. There is very little information regarding the pharmacology of this compound within the scientific literature. Despite this, however, it is available for sale as a grey area research chemical through online vendors.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Smoked | 0.5-1.5mg | 1.5-2mg | 2-4mg | 4mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Smoked | 0 min | 12-48 min | 12-30 min | 6-12 min | 12-48 min | 1800-0 min |
Tolerance
Build-up
develops over weeks of regular use via CB1 receptor downregulation
Reset
2–4 weeks for most users; heavy users may need longer
Effects
Positive
- Pain relief
- Stimulation
Negative
- Dry mouth
- Tachycardia
- Nausea/vomiting
- Strong dysphoria on comedown
- Nausea
- Red eyes
- Spontaneous bodily sensations
- Vasodilation
Positive
- Thought connectivity
- Mindfulness
- Conceptual thinking
- Euphoria
Negative
- Anxiety
- Paranoia
- Rapid, intense intoxication
- Anxiolysis or severe anxiety/panic
- Time distortion
- Dissociation at high doses
Positive
- Increased music appreciation
- Auditory acuity enhancement
Negative
- Dehydration
- Visual sharpening or mild pseudo-hallucinations
- Dulled perception
- Auditory distortion
- Changes in felt gravity
- Perception of bodily heaviness
- Appetite intensification
- Drifting