Home
    Disclaimer
    ← Back to Sulbutiamine
    Sulbutiamine molecular structure

    Sulbutiamine Stats & Data

    Stimulant Supplement
    Sulbut Enerion Arcalion Youvitan Bisibuthiamine
    NPS DataHub
    MW702.9
    FormulaC32H46N8O6S2
    CAS3286-46-2
    IUPAC[(Z)-4-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-3-[[(Z)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-(2-methylpropanoyloxy)pent-2-en-3-yl]disulfanyl]pent-3-enyl] 2-methylpropanoate
    SMILESO=CN(Cc1cnc(C)nc1N)C(C)=C(CCOC(=O)C(C)C)SSC(CCOC(=O)C(C)C)=C(C)N(C=O)Cc1cnc(C)nc1N
    InChIKeyCKHJPWQVLKHBIH-ZDSKVHJSSA-N
    Psychoactive Class Stimulant

    Pharmacology

    DrugBank

    Description

    Sulbutiamine is a synthetic derivative of thiamine (vitamin B1) under the market name Arcalion that is composed of two modified thiamine molecules to form a dimer. It is highly lipophilic, allowing it to cross the blood-brain barrier more easily than other thiamine derivatives. Although its clinical efficacy is not yet defined, sulbutiamine is used to treat asthenia. While its other uses include improvement of erectile dysfunction and reduction of psycho-behavioural inhibition, sulbutiamine showed evidence of modulatory effect on dopaminergic and glutamatergic cortical transmissions. The chronic administration of the drug has demonstrated to improve long term memory formation in mice.

    Effect Profile

    Curated + 2 Reports
    Stimulant 3.8

    Strong anxiety/jitters with moderate stimulation and euphoria

    Stimulation / Energy×3
    6
    Euphoria / Mood Lift×2
    6
    Focus / Productivity×2
    0
    Anxiety / Jitters×1
    10
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Sulbutiamine

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 1d Half tolerance 10d Baseline ~18d

    Experience Report Analysis

    Erowid
    2 Reports
    2009–2020 Date Range
    2 With Age Data

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Read full reports on Erowid →
    ← Back to Sulbutiamine