Consumption: 2 pills on empty stomach. At other times ingested just before a meal. Times used the aforementioned ways: 4 to 6 times. Suggested dosage is one pill [prescribed for female weighing 155 pounds]. I take 2 pills (4mg each) to see what feeling I get. T+0.0- Average day. Average body feelings. Slightly tired.
Tizanidine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 1 ROA with full dose ladder
- duration data present
- toxicity data (PsychonautWiki, PubChem)
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 1 ROA with full dose ladder
- duration data present
- toxicity data (PsychonautWiki, PubChem)
Aliases: Tizanidine hcl
Summary
Tizanidine (known by the trade names Zanaflex and Trinex among others) is a depressant substance of the imidazoline class closely related to clonidine. Tizanidine is primarily used primarily as an antispasmodic drug. Tizanidine's effectivness is similar to that of baclofen or diazepam .
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 2-3mg | 4-5mg | 6-8mg | 8mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak |
|---|---|---|
| Oral | 12-48 min | 1-2 hrs |
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Tizanidine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
⬇ Download import file
Import this file as custom substances
and you get "Tizanidine (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Name
Tizanidine
Unit
mg
Description
Tizanidine Source: SubstanceSearch (substancesearch.com) Oral dose (mg): light 2-3 · common 4-5 · strong 6-8 · heavy 8+ Oral duration: onset 12-48m · peak 1-2h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 4.5 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Build-up
develops over 1–4 weeks of regular use
Reset
days to weeks depending on duration of use
Tolerance Decay
Full tolerance
3d
Half tolerance
8d
Baseline
~14d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Positive
- Stimulation
- Physical euphoria
- Muscle relaxation
- Spontaneous tactile sensations
Negative
- Motor impairment
- Nausea
- Increased heart rate
- Respiratory depression
- Sedation
- Difficulty urinating
Positive
- Reduced anxiety
- Euphoria
- Cognitive euphoria
- Anxiety suppression
Negative
- Thought deceleration
- Anxiety
- Memory suppression
- Compulsive redosing
- Dizziness
- Time distortion
Positive
- Increased libido
- Increased music appreciation
Negative
- Dehydration
- Disinhibition
- Appetite suppression
- Dulled perception
- Internal hallucinations
- Auditory hallucinations
- Drifting
- Auditory distortion
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 2 reports 2 cautionary visit
Consumption: 3+1 pills on an empty stomach. Had 3 pills and 2 hours later took a 4th one. I quit doing drugs after a amazing LSA trip that changed the way I view many things in life, my relationship with my parents, my friendships, and the way I viewed drugs.
Pill Identifiers
34
known pill identifiers on record — view imprints, colors, shapes, and images
→
Tizanidine's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Tizanidine? Let us know. Reports are reviewed by moderators — this is not posted publicly.