Consumption: 2 pills on empty stomach. At other times ingested just before a meal. Times used the aforementioned ways: 4 to 6 times. Suggested dosage is one pill [prescribed for female weighing 155 pounds]. I take 2 pills (4mg each) to see what feeling I get. T+0.0- Average day. Average body feelings. Slightly tired.
Tizanidine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 1 ROA with full dose ladder
- duration data present
- PubChem toxicity data
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 1 ROA with full dose ladder
- duration data present
- PubChem toxicity data
Aliases: Tizanidine hcl
Summary
Tizanidine (known by the trade names Zanaflex and Trinex among others) is a depressant substance of the imidazoline class closely related to clonidine. Tizanidine is primarily used primarily as an antispasmodic drug. Tizanidine's effectivness is similar to that of baclofen or diazepam .
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 2-3μg | 4-5μg | 6-8μg | 8μg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak |
|---|---|---|
| Oral | 12-48 min | 1-2 hrs |
Tolerance
Build-up
develops over 1–4 weeks of regular use
Reset
days to weeks depending on duration of use
Tolerance Decay
Full tolerance
3d
Half tolerance
8d
Baseline
~14d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Positive
- Stimulation
- Physical euphoria
- Muscle relaxation
- Spontaneous tactile sensations
Negative
- Motor impairment
- Nausea
- Increased heart rate
- Respiratory depression
- Sedation
- Difficulty urinating
Positive
- Reduced anxiety
- Euphoria
- Cognitive euphoria
- Anxiety suppression
Negative
- Thought deceleration
- Anxiety
- Memory suppression
- Compulsive redosing
- Dizziness
- Time distortion
Positive
- Increased libido
- Increased music appreciation
Negative
- Dehydration
- Disinhibition
- Appetite suppression
- Dulled perception
- Internal hallucinations
- Auditory hallucinations
- Drifting
- Auditory distortion
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 2 reports 1 neutral 1 cautionary visit
Consumption: 3+1 pills on an empty stomach. Had 3 pills and 2 hours later took a 4th one. I quit doing drugs after a amazing LSA trip that changed the way I view many things in life, my relationship with my parents, my friendships, and the way I viewed drugs.
Pill Identifiers
34
known pill identifiers on record — view imprints, colors, shapes, and images
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Tizanidine's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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