TMA-6 Stats & Data

TMA-6 emerged from Alexander Shulgin's systematic exploration of trimethoxyamphetamines. After discovering that relocating a single methoxy group from the original TMA (3,4,5-trimethoxyamphetamine) to create TMA-2 resulted in a ten-fold increase in potency, Shulgin prioritized investigating all six possible arrangements of the three methoxy groups on the amphetamine scaffold. TMA-6, featuring the 2,4,6-trimethoxy pattern, was assigned its sequential name in 1970 alongside TMA-3, TMA-4, and TMA-5. The compound's precursor, phloroglucinol, occurs naturally in sources as diverse as coast redwood cones, tea plant leaves (Camellia species), citrus rinds, and Eucalyptus resins. Although the compound had been described in scientific literature as early as 1954, Shulgin discovered its psychedelic properties in 1964 and published the first account of its hallucinogenic effects in 1969, noting its potency relative to mescaline. He provided a more comprehensive description in his 1991 book PiHKAL (Phenethylamines I Have Known And Loved), where he characterized it as "one of the most rewarding and pleasurable of the methoxylated amphetamines." Prior to this publication, the compound had no documented history of human use outside Shulgin's research. Following PiHKAL's release, TMA-6 gained limited recognition within the psychedelics community and appeared as a novel designer drug in Europe in 2009, though it remains only sporadically available from clandestine sources.

Effects aggregated from 7 experience reports (7 Erowid)

From 9 individual dose entries

Most common forms and preparations reported