Summary
2,4,6-Trimethoxyamphetamine (also known as TMA-6) is a lesser-known psychedelic substance of the amphetamine class. It has been reported to produce a complex mixture of stimulant, hallucinogenic and entactogenic effects that distinguish it from other psychedelic phenethylamine derivatives like the 2C-x or DOx series.
Perspectives
“I was outside at the California-Washington State football game, which was completely nutty. As was I. With the crowd activity, it was impossible to separate the drug’s action from the environment. Later I simply sat in the car, and tried to define what the effects really were. Things were completely benign, there was ease with concepts, and writing was good and smooth. At twelve hours, comfortably down. Maybe a plus two.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 10-20mg | 20-35mg | 35-50mg | 50mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 30-90 min | 1.5-3 hrs | 5-8 hrs | 3-5 hrs | 10-17.5 hrs |
Effect Profile
7 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Moderate body load with low headspace and visuals
Strong anxiety/jitters with mild stimulation, low euphoria and focus
Tolerance
Tolerance Decay
Effects
Aggregated from 7 Erowid experience reports
Positive Effects 3
Adverse Effects 1
Combinations
PiHKAL / TiHKAL
“I was outside at the California-Washington State football game, which was completely nutty. As was I. With the crowd activity, it was impossible to separate the drug’s action from the environment. Later I simply sat in the car, and tried to define what the effects really were. Things were completely benign, there was ease with concepts, and writing was good and smooth. At twelve hours, comfortably down. Maybe a plus two.”