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U-47700 Stats & Data

Depressant Research-chemical Opioid

U4 Pink Pinky Pink heroin u47700

PubChem CID 71719125

NPS DataHub

MW329.27

FormulaC16H22Cl2N2O

CAS121348-98-9

IUPAC3,4-dichloro-N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-N-methylbenzamide

SMILESCN(C)C1CCCCC1N(C)C(=O)c1ccc(Cl)c(Cl)c1

InChIKeyJGPNMZWFVRQNGU-LSDHHAIUSA-N

Opioids; 2020/4. Von N-(2-Aminocyclohexyl)amid abgeleitete Verbindungen; 2021/4. Von N-(2-Aminocyclohexyl)amid abgeleitete Verbindungen; 2022/4. Von N-(2-Aminocyclohexyl)amid abgeleitete Verbindungen

Chemical Class Opioid

Psychoactive Class Depressant

Pharmacology

DrugBank

Mechanism of Action

/ALTERNATIVE and IN VITRO TESTS/ U-47700 /was evaluated/ for its in vitro binding activity using guinea pig brain at the mu opioid receptor (MOR) and the kappa opioid receptor (KOR). U-47700 had high affinity at the MOR and bound with a KD of 5.3 nM and weakly at the KOR with a KD of 910 nM resulting in a >171x preference for the MOR relative to the KOR. (14) Subsequently these researchers reported U-47700 receptor affinities (IC50s) of 9 and 300 nM, respectively, for the MOR and KORs.

Metabolism

Recently, the number of adverse events, including death, involving novel opioids has continued to increase, providing additional and sustained challenges for forensic and medical communities. Identification of emerging novel opioids can be challenging, compounded by detection windows and unknown metabolic profiles. In this study, human liver microsomes were used for the generation of in vitro metabolic profiles of U-47700 and U-49900. Generated metabolites were analyzed via a SCIEX TripleTOF 560

Receptor Profile

Receptor Actions

Agonists

μ-opioid receptor agonist (full)

κ-opioid receptor agonist (weak)

δ-opioid receptor agonist (very weak)

Toxicity

PsychonautWiki

U-47700 has a high toxicity relative to its dose due to its extreme potency. As with all opioids, long-term effects can vary but can include diminished libido, apathy and memory loss. It is also potentially lethal when mixed with [[depressants like alcohol or benzodiazepines]]. It is worth noting that U-47700 crystals are particularly corrosive and somewhat caustic to mucous membranes. Careless use may deteriorate the chosen routes of administration so it is important to practice routine maintenance such as soaking the sinus cavity with water prior to and following insufflation.

Effect Profile

Curated + 9 Reports

Opioid 8.0

Strong euphoria and pain relief with mild sedation and itching/nausea

Euphoria / Warmth×3

Analgesia×2

Sedation / Relaxation×1

Itching / Nausea×1

Based on reports from:

Erowid Experience Reports PsychonautWiki U-47700

Tolerance & Pharmacokinetics

drugs.wiki

Tolerance Decay

Full tolerance 1d Half tolerance 21d Baseline ~35d

Experience Report Analysis

Erowid

9 Reports

2014–2017 Date Range

9 With Age Data

4 Effects Detected

Demographics

Gender Distribution

Age Distribution

Reports Over Time

Effect Analysis

Erowid

Effects aggregated from 9 experience reports (9 Erowid)

9 Reports

4 Effects Detected

3 Positive

0 Adverse

1 Neutral

Effect Sentiment Distribution

Confidence Distribution

Positive Effects 3

Sedation 44.4% 70%

Euphoria 44.4% 70%

Anxiety Suppression 33.3% 70%

Adverse Effects 0

Form / Preparation

Most common forms and preparations reported

Read full reports on Erowid →

Legal Status

Country	Status	Notes
Austria	illegal	Controlled under SMG (Suchtmittelgesetz) since June 26, 2019.
Czech Republic	controlled	Schedule I controlled substance.
Sweden	illegal	Classified as a narcotic substance.
United Kingdom	controlled	Class A, Schedule 1 substance.
United States	controlled	Schedule I since October 2016. Originally temporarily scheduled; now permanently controlled as a synthetic opioid.
United States - Florida	controlled	Emergency scheduled at state level.
United States - Ohio	controlled	Emergency scheduled at state level.

References

Data Sources

Cited References

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