U-49900 Stats & Data
PubChem
MW357.3
FormulaC18H26Cl2N2O
LogP4.7
IUPAC3,4-dichloro-N-[(1R,2R)-2-(diethylamino)cyclohexyl]-N-methylbenzamide
SMILES
CCN(CC)C1CCCCC1N(C)C(=O)C2=CC(=C(C=C2)Cl)ClInChIKey
AXACJBKFKCCIOR-IAGOWNOFSA-N
Chemical Class
Opioid
Psychoactive Class
Depressant
Effect Profile
Curated
Opioid
3.9
Moderate euphoria with mild itching/nausea, low sedation
Euphoria / Warmth×3
6
Analgesia×2
0
Sedation / Relaxation×1
3
Itching / Nausea×1
4
Based on reports from:
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Full tolerance
1d
Half tolerance
21d
Baseline
~35d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.