Summary
A substance that is structurally related to benzodiazepines. Is only used in Veterinary medicine. It is usually used in tandem with either the potent NMDA antagonist Tiletamine (at a 1:1 ratio) or with the ฮฑ2 adrenergic receptor agonist Xylazine. Is roughly around four times the potency of Diazepam. Yet is water soluable.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated | 1-3mg | 3-6mg | 6-12mg | 12mg+ |
| Intramuscular | 1-3mg | 3-5mg | 5-10mg | 10mg+ |
| Oral | 2.5-5mg | 5-10mg | 10-20mg | 20mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | After Effects |
|---|---|---|---|
| Insufflated | 5-10 min | 2.0-3.0 hrs | 1.0-4.0 hrs |
| Intramuscular | 1-5 min | 2.0-4.0 hrs | 1.0-3.0 hrs |
| Oral | 10-30 min | 4.0-6.0 hrs | 1.0-6.0 hrs |
Tolerance
Build-up
develops over 1โ4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
Reset
weeks to months depending on half-life and duration of use; taper recommended
Effects
Positive
- Stimulation
- Physical euphoria
- Muscle relaxation
Negative
- Motor impairment
- Increased heart rate
- Nausea
- Vasoconstriction
- Respiratory depression
- Teeth grinding
- Sedation
Positive
- Reduced anxiety
- Cognitive euphoria
- Euphoria
- Anxiety suppression
- Wakefulness
Negative
- Anxiety
- Compulsive redosing
- Dizziness
- Thought deceleration
- Time distortion
Positive
- Increased music appreciation
- Increased libido
- Tactile enhancement
- Color enhancement
Negative
- Disinhibition
- Appetite suppression
- Dehydration
- Light sensitivity
- Double vision
- Dulled perception