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    Disclaimer
    ⚠ Benzodiazepines can cause physical dependence with regular use. Withdrawal can be life-threatening. Never combine with opioids or alcohol.

    Zolazepam Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • 3 ROAs with full dose ladders
    • duration data present
    • 17 combo interactions documented

    Depressant Benzodiazepine

    Summary TripSit

    A substance that is structurally related to benzodiazepines. Is only used in Veterinary medicine. It is usually used in tandem with either the potent NMDA antagonist Tiletamine (at a 1:1 ratio) or with the α2 adrenergic receptor agonist Xylazine.

    Dose Information TripSit

    ROA Light Common Strong Heavy
    Insufflated 1-3mg 3-6mg 6-12mg 12mg+
    Intramuscular 1-3mg 3-5mg 5-10mg 10mg+
    Oral 2.5-5mg 5-10mg 10-20mg 20mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TripSit

    ROA Onset Peak After Effects
    Insufflated 5-10 min 2-3 hrs 1-4 hrs
    Intramuscular 1-5 min 2-4 hrs 1-3 hrs
    Oral 10-30 min 4-6 hrs 1-6 hrs

    Effect Profile

    3 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Benzodiazepine 7.6
    Intense 8/10

    Strong euphoria and anxiolysis with mild sedation, low cognitive impairment

    Anxiolysis ×3
    8
    anxiety suppression reduced anxiety muscle relaxation
    Sedation / Relaxation ×2
    5
    sedation muscle relaxation
    ⚠ Motor / Cognitive Impairment ×1
    1
    double vision
    Euphoria / Mood Lift ×1
    10
    cognitive euphoria euphoria physical euphoria disinhibition
    Based on reports from:
    Erowid Experience Reports
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Zolazepam there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "Zolazepam (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    Zolazepam
    Unit
    mg
    Description 
    Zolazepam
Source: SubstanceSearch (substancesearch.com)

Insufflated dose (mg): light 1-3 · common 3-6 · strong 6-12 · heavy 12+
Intramuscular dose (mg): light 1-3 · common 3-5 · strong 5-10 · heavy 10+
Oral dose (mg): light 2.5-5 · common 5-10 · strong 10-20 · heavy 20+

Insufflated duration: onset 5-10m · peak 2-3h · after-effects 1-4h
Intramuscular duration: onset 1-5m · peak 2-4h · after-effects 1-3h
Oral duration: onset 10-30m · peak 4-6h · after-effects 1-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 4.5 mg (Insufflated).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
    Reset weeks to months depending on half-life and duration of use; taper recommended

    Tolerance Decay

    Full tolerance 3d Half tolerance 37d Baseline ~60d

    Effects

    Positive
    • Stimulation
    • Physical euphoria
    • Muscle relaxation
    Negative
    • Motor impairment
    • Increased heart rate
    • Nausea
    • Vasoconstriction
    • Respiratory depression
    • Teeth grinding
    Neutral
    • Sedation
    Positive
    • Reduced anxiety
    • Cognitive euphoria
    • Euphoria
    • Anxiety suppression
    • Wakefulness
    Negative
    • Anxiety
    • Compulsive redosing
    • Dizziness
    • Thought deceleration
    Neutral
    • Time distortion
    Positive
    • Increased music appreciation
    • Increased libido
    • Tactile enhancement
    • Color enhancement
    Negative
    • Disinhibition
    • Appetite suppression
    • Dehydration
    • Light sensitivity
    • Double vision
    Neutral
    • Dulled perception

    Combinations TripSit

    Cross-Check Zolazepam with another substance

    Zolazepam's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

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