1B-LSD
Aliases: 1b, 1-butyryl-lsd
Summary
1B-LSD is an N1-acylated prodrug that is rapidly hydrolyzed in vitro and in vivo to LSD via CYP1A2 and CYP3A4 enzymes. Animal studies show approximately 14% the potency of LSD by weight; blotters marketed at 100 ug 1B-LSD produce subjective effects comparable to 75-100 ug LSD in many users. Because it is a prodrug, CYP1A2/3A4 inhibitors or inducers could alter intensity and onset.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 25-75µg | 75-150µg | 150-300µg | 300µg+ |
| Sublingual | 25-75µg | 75-150µg | 150-300µg | 300µg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 19-60 min | 0.75-2 hrs | 3-5 hrs | 3-5 hrs | 8-12 hrs |
| Sublingual | 19-60 min | 0.75-2 hrs | 3-5 hrs | 3-5 hrs | 8-12 hrs |
Effect Profile
2 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong visuals, headspace, and auditory effects with moderate body load
Tolerance
Tolerance Decay
Rapid tolerance after a single session; meaningful reduction after ~5–7 days; near‑baseline by ~14 days is typical for LSD‑like psychedelics. Data are based on human experience and general psychedelic pharmacology rather than controlled trials.
Cross-Tolerances
Effects
- Stimulation
- Physical euphoria
- Stamina enhancement
- Creativity enhancement
- Pupil dilation
- Nausea
- Vasoconstriction
- Increased heart rate
- Increased blood pressure
- Increased perspiration
- Seizure
- Muscle twitching
- Spontaneous bodily sensations
- Difficulty urinating
- Excessive yawning
- Muscle contractions
- Increased salivation
- Stamina intensification
- Analysis enhancement
- Conceptual thinking
- Emotion enhancement
- Personal meaning enhancement
- Cognitive euphoria
- Laughter fits
- Wakefulness
- Novelty enhancement
- Unity and interconnectedness
- Increased sense of humor
- Immersion intensification
- Anxiety
- Delusion
- Paranoia
- Thought disorganization
- Memory suppression
- Time distortion
- Thought acceleration
- Ego dissolution
- Machinescapes
- Depth perception distortions
- Recursion
- Perspective distortion
- Multiple thought streams
- Personality regression
- Thought loop
- Personal bias suppression
- Existential self-realization
- Ego replacement
- Emotion intensification
- Focus intensification
- Personal meaning intensification
- Suggestibility intensification
- Spirituality intensification
- Tactile enhancement
- Colour enhancement
- Visual acuity enhancement
- Pattern recognition enhancement
- Tracers
- Increased music appreciation
- Synaesthesia
- Increased libido
- Bodily control enhancement
- Color enhancement
- Color shifting
- Auditory acuity enhancement
- Appetite suppression
- Visual drifting
- After images
- Symmetrical texture repetition
- Internal hallucination
- Auditory hallucination
- Auditory distortion
- Scenery slicing
- External hallucination
- Autonomous entity
- Drifting
- Color tinting
- Perspective hallucination
- Tactile intensification