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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    1cP-MiPLA Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 19 combo interactions documented
    • toxicity data (PsychonautWiki)
    • classified Research-chemical

    Psychedelic Research-chemical

    Summary dose.wiki PsychonautWiki

    1cP-MiPLA (1-cyclopropionyl-N-methyl-N-isopropyllysergamide) is a novel lysergamide first appearing on research chemical markets around 2020. It acts as a prodrug that rapidly hydrolyzes to MiPLA, similar to how 1P-LSD converts to LSD. Potency is approximately 60-80% of LSD by weight; many users find 150 ug comparable to 100 ug LSD.

    Dose Information dose.wiki PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 100-150µg 150-200µg 200-250µg 300µg+
    Sublingual 100-150µg 150-200µg 200-250µg 300µg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 20-40 min 45-90 min 1-2 hrs 1-2 hrs 2-6 hrs 3.08-6.17 hrs
    Sublingual 20-40 min 45-90 min 1-2 hrs 1-2 hrs 2-6 hrs 3.08-6.17 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 7.5
    Intense 8/10

    Strong visuals and auditory effects with moderate headspace and body load

    Visual Intensity ×3
    10
    color enhancement drifting tracers pattern recognition enhancement scenery slicing color shifting +3 more
    Headspace Depth ×3
    6
    conceptual thinking emotion enhancement thought loops time distortion
    Auditory Effects ×1
    8
    auditory distortion auditory hallucination
    ⚠ Body Load / Somatic Effects ×1
    6
    temperature regulation suppression nausea increased heart rate
    View methodology →

    Add missing routes to PsychonautWiki Journal

    The PsychonautWiki Journal app already has 1cP-MiPLA, but its built-in entry only covers Oral. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.

    ⬇ Download import file Import this file as custom substances and you get "1cP-MiPLA (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Custom Unit doses
    • Sublingualcommon ~ 175 µg
    Dose & duration (reference) 
    1cP-MiPLA: routes the PsychonautWiki Journal app is missing
Source: SubstanceSearch (substancesearch.com)

Sublingual dose (µg): threshold 40ug · light 100-150 · common 150-200 · strong 200-250 · heavy 300+

Sublingual duration: onset 20-40m · come-up 0.75-1.5h · peak 1-2h · offset 1-2h · total 3.08-6.17h · after-effects 2-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Custom Units carry a single dose per route, so the full ranges live in the reference above. A route's suggested dose is the midpoint of its common range. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops rapidly after a single use (lysergamide)
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 6h Half tolerance 5d Baseline ~14d

    Functional tolerance to lysergamides rises rapidly within a single session and decays over 5–14 days; acute redosing beyond ~45–60 min is typically inefficient. Cross‑tolerance is expected across serotonergic psychedelics that act via 5‑HT2A.

    Cross-Tolerances

    LSD
    80%
    Psilocybin/psilocin
    60%
    Other serotonergic psychedelics
    50%

    Effects dose.wiki PsychonautWiki

    Positive
    • Stimulation
    • Physical euphoria
    Negative
    • Pupil dilation
    • Temperature regulation suppression
    • Increased perspiration
    • Nausea
    • Increased heart rate
    • Increased blood pressure
    • Seizure
    • Muscle twitching
    Neutral
    • Spontaneous bodily sensations
    • Difficulty urinating
    • Excessive yawning
    • Muscle contractions
    • Increased salivation
    • Increased bodily temperature
    • Stamina intensification
    Positive
    • Analysis enhancement
    • Cognitive euphoria
    • Emotion enhancement
    • Wakefulness
    • Motivation enhancement
    • Novelty enhancement
    • Conceptual thinking
    • Unity and interconnectedness
    • Laughter fits
    • Increased sense of humor
    • Immersion intensification
    Negative
    • Memory suppression
    • Thought loops
    • Delusion
    Neutral
    • Time distortion
    • Thought acceleration
    • Machinescapes
    • Depth perception distortions
    • Thought loop
    • Existential self-realization
    • Emotion intensification
    • Focus intensification
    Positive
    • Tactile enhancement
    • Color enhancement
    • Pattern recognition enhancement
    • Visual acuity enhancement
    • Tracers
    • Increased music appreciation
    • Increased libido
    • Bodily control enhancement
    • Color shifting
    • Auditory acuity enhancement
    Negative
    • Appetite suppression
    Neutral
    • Changes in felt bodily form
    • Drifting
    • After images
    • Geometric visual patterns
    • Mild internal hallucinations
    • Auditory hallucination
    • Auditory distortion
    • Diffraction
    • Symmetrical texture repetition
    • Scenery slicing
    • External hallucination
    • Internal hallucination
    • Autonomous entity
    • Perspective hallucination
    • Tactile intensification

    Combinations

    Cross-Check 1cP-MiPLA with another substance

    1cP-MiPLA's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki