2-Chloroephenidine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- classified Tentative
- classified Research-chemical
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- classified Tentative
- classified Research-chemical
Aliases: 2-cl-eph, 2-cl-ephenidine, 2-cl-diphenidine, 2chloroephenidine, 2clephenidine, 2-chloro-ephenidine
Summary
2-Chloroephenidine has the highest NMDA receptor affinity within the diphenidine family in vitro, though in vivo potency appears comparable to ephenidine. Very limited human safety data exists. Users report poorer urinary tract tolerance compared to other dissociatives and a steep dose-response curve above 150 mg.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 100-130mg | 130-175mg | 175-200mg | 200mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 20-60 min | 30-60 min | 1-2.5 hrs | 2-4 hrs | 3-6 hrs |
| Rectal | 10-20 min | 20-40 min | 1-2.5 hrs | 2-4 hrs | 3-6 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong dissociative depth and motor impairment with mild mania, low insight
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track 2-Chloroephenidine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
2-Chloroephenidine Source: SubstanceSearch (substancesearch.com) Oral dose (mg): light 100-130 · common 130-175 · strong 175-200 · heavy 200+ Rectal dose (mg): threshold 5 Oral duration: onset 0.33-1h · come-up 0.5-1h · peak 1-2.5h · offset 2-4h · total 3-6h · after-effects 2-6h Rectal duration: onset 10-20m · come-up 20-40m · peak 1-2.5h · offset 2-4h · total 3-6h · after-effects 2-6h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 152.5 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
- Pain relief
- Stimulation
- Physical euphoria
- Spontaneous tactile sensations
- Numbness
- Loss of balance
- Increased heart rate
- Clumsiness in movement
- Physical disconnection
- Tactile disconnection
- Euphoria
- Conceptual thinking
- Cognitive euphoria
- Cognitive disconnection
- Motor control loss
- Depersonalization
- Derealization
- Anxiety
- Dissociation
- Time distortion
- Perception of bodily lightness
- Tactile suppression
- Double vision
- Acuity suppression
- Auditory suppression
- Visual disconnection
- Visual drifting
- Internal hallucinations
- Auditory distortion
- Auditory hallucinations
Combinations
Cross-Check 2-Chloroephenidine with another substanceHelpful Links
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