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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2-Chloroephenidine

    Aliases: 2-cl-eph, 2-cl-ephenidine, 2-cl-diphenidine, 2chloroephenidine, 2clephenidine, 2-chloro-ephenidine

    Dissociative Research-chemical

    Summary TheDrug.Wiki TripSit

    2-Chloroephenidine has the highest NMDA receptor affinity within the diphenidine family in vitro, though in vivo potency appears comparable to ephenidine. Very limited human safety data exists. Users report poorer urinary tract tolerance compared to other dissociatives and a steep dose-response curve above 150 mg.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 100-130mg 130-175mg 175-200mg 200mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 20-60 min 30-60 min 1-2.5 hrs 2-4 hrs 2-6 hrs 3.8-8.5 hrs
    Rectal 10-20 min 20-40 min 1-2.5 hrs 2-4 hrs 2-6 hrs 3.5-7.5 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Dissociative 6.0
    Strong 6/10

    Strong dissociative depth and motor impairment with mild mania, low insight

    Dissociative Depth ×3
    10
    depersonalization derealization physical disconnection tactile disconnection cognitive disconnection visual disconnection +1 more
    ⚠ Mania / Compulsion ×1
    4
    stimulation euphoria
    Insight / Novel Thought ×2
    3
    conceptual thinking
    ⚠ Motor / Sensory Impairment ×1
    10
    motor control loss physical disconnection tactile disconnection tactile suppression numbness visual disconnection +1 more
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 2-Chloroephenidine
    View methodology →

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2–4 weeks for noticeable reduction

    Tolerance Decay

    Full tolerance 1d Half tolerance 21d Baseline ~28d

    Effects TheDrug.Wiki

    Positive
    • Pain relief
    • Stimulation
    • Physical euphoria
    • Spontaneous tactile sensations
    Negative
    • Numbness
    • Loss of balance
    • Increased heart rate
    • Clumsiness in movement
    Neutral
    • Physical disconnection
    • Tactile disconnection
    Positive
    • Euphoria
    • Conceptual thinking
    • Cognitive euphoria
    Negative
    • Cognitive disconnection
    • Motor control loss
    • Depersonalization
    • Derealization
    • Anxiety
    Neutral
    • Dissociation
    • Time distortion
    Positive
    • Perception of bodily lightness
    Negative
    • Tactile suppression
    • Double vision
    • Acuity suppression
    • Auditory suppression
    Neutral
    • Visual disconnection
    • Visual drifting
    • Internal hallucinations
    • Auditory distortion
    • Auditory hallucinations

    Combinations TripSit

    2-Chloroephenidine's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 TripSit 📖 PsychonautWiki