2-Chloroephenidine Stats & Data
2-cl-eph
2-cl-ephenidine
2-cl-diphenidine
2chloroephenidine
2clephenidine
2-chloro-ephenidine
PubChem
MW259.77
FormulaC16H18ClN
LogP4.3
IUPAC2-(2-chlorophenyl)-N-ethyl-1-phenylethanamine
InChIKey
CIZLUPKWIPWOID-UHFFFAOYSA-N
Psychoactive Class
Dissociative
Receptor Profile
Receptor Actions
Antagonists
NMDA receptor antagonist (noncompetitive)
Effect Profile
Curated
Dissociative
6.0
Strong dissociative depth and motor impairment with mild mania, low insight
Dissociative Depth×3
10
Mania / Compulsion×1
4
Insight / Novel Thought×2
3
Motor / Sensory Impairment×1
10
Based on reports from:
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Full tolerance
1d
Half tolerance
21d
Baseline
~28d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
References
Cited References
- Bluelight: New dissociative RCs thread (2014-2015)
- Journal of Psychopharmacology - Pharmacological investigations of diphenidine analogues (2016)
- Nervewing: Diarylethylamines overview (2020)
- PiHKAL.info - 2-Chloroephenidine (IUPAC & molecular data)
- PLOS ONE - Pharmacological Investigations of Dissociative 'Legal Highs' (2016)
- PubChem: CID 43489092 - 2-Chloro-ephenidine
- TripSit: Factsheet - 2-Chloroephenidine
- UK ACMD - Diphenidine diarylethylamine review (2023)
- UK ACMD diarylethylamine report (2023)
- NCATS Inxight entry – 2-Chloro-ephenidine
- Bluelight: TR – 100 mg rectal 2-Cl-Eph (2015)
- Designing novel diarylethylamines overview (Bluelight, 2020)
- Pharmacological investigations of diphenidine analogues (J Psychopharmacol 2016)
- Receptor-binding heat-map of diarylethylamines (2016)
- Reddit: r/researchchemicals binding-affinity thread (2023)
- List of designer drugs – diarylethylamines
- Wiley NPS laboratory testing review (2023)
- Enantiomeric separation of diphenidine derivatives (J Chromatogr B 2025)
- Structure–activity summary of diarylethylamines (ResearchGate 2024)
- French Addictovigilance Network – phenidine complications (2019)
- PubChem: 2 Chloro ephenidine