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    2-FMA molecular structure

    2-FMA Stats & Data

    2-fluoro-methamphetamine 2fma
    NPS DataHub
    MW167.23
    FormulaC10H14FN
    CAS1017176-48-5
    IUPAC1-(2-fluorophenyl)-N-methylpropan-2-amine
    SMILESCNC(C)Cc1ccccc1F
    InChIKeyXNWIKJYFOIDUGD-UHFFFAOYSA-N
    Phenethylamines; 2020/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2021/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2022/1. Von 2-Phenethylamin abgeleitete Verbindungen
    Chemical Class Amphetamine
    Psychoactive Class Stimulant

    Interaction Warnings

    stimulants

    2-FMA can be potentially dangerous in combination with other stimulants as it can increase one's heart rate and blood pressure to dangerous levels.

    mdma

    The neurotoxic effects of MDMA may be increased when combined with amphetamines.

    cocaine

    This combination may increase strain on the heart.

    Receptor Profile

    Receptor Actions

    Inhibitors
    Norepinephrine reuptake inhibitor
    Other
    Dopamine-norepinephrine releasing agent (DNRA)

    History & Culture

    2-FMA emerged on the online research chemical market in August 2007, appearing alongside other fluorinated amphetamines such as 2-FA and 4-FA. That same month, forensic analysis of capsules delivered to Royal Adelaide Hospital in Australia revealed the presence of 2-FMA. The capsules appeared to have originated from Neorganics, an Israeli company that was distributing drug-containing capsules internationally under various brand names, with the 2-FMA-containing product marketed as "Sub Coca 2." Analysis found the capsules contained 2-FMA in combination with α-phthalimidopropiophenone. Despite its early appearance on the market, 2-FMA remained relatively obscure for several years. The substance was first reported to the European Monitoring Centre for Drugs and Drug Addiction in 2012, with most user reports emerging from 2013 onward. An analysis of 162 seized drug samples in Italy between September 2013 and June 2015 found 2-FMA present in only a small number of samples, indicating its limited prevalence compared to other novel psychoactive substances during this period. The compound remains unknown in clinical and research literature, with virtually no formal pharmacological studies published. At least one fatality has been reported in connection with 2-FMA, though in that case the substance appeared to have been mislabeled. A male in his early twenties who had purchased what he believed to be 4-FMA online used it in combination with 3-MMC and codeine/acetaminophen tablets. He became unresponsive within minutes of administration and could not be resuscitated by paramedics. Subsequent toxicological analysis determined the substance was actually 2-FMA rather than 4-FMA, highlighting the risks associated with mislabeled research chemicals purchased from online vendors. Within online drug communities, 2-FMA has gained some attention as a component of the "Borax Combo," a combination designed to produce effects similar to MDMA. One common formulation combines 2-FMA with 5-MAPB and 4-HO-MET, with 2-FMA serving primarily to provide the stimulant component of the mixture.

    Subjective Effect Notes

    In comparison to other substituted amphetamines, 2-FMA is particularly free of side effects such as nausea, high blood pressure, anxiety and an uncomfortable offset. It is considered to be an extremely functional and effective psychoactive substance for performing general productivity tasks of any sort. However, at higher doses, it becomes less of a productivity boost and more for recreational purposes due to the intensity of its euphoria and stimulation.

    physical: The physical effects of 2-FMA can be broken down into several components which progressively intensify proportional to dosage.

    cognitive: The cognitive effects of 2-FMA can be broken down into several components which progressively intensify proportional to dosage.

    Effect Profile

    Curated
    Stimulant 6.6

    Strong euphoria, anxiety/jitters, and focus with mild stimulation

    Stimulation / Energy×3
    5
    Euphoria / Mood Lift×2
    10
    Focus / Productivity×2
    9
    Anxiety / Jitters×1
    10

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 1d Half tolerance 12d Baseline ~21d

    Cross-Tolerances

    Amphetamine
    75% ●○○
    Methamphetamine
    75% ●○○
    Lisdexamfetamine
    75% ●○○
    2-FA
    75% ●○○
    3-FA
    75% ●○○
    4-FA
    40% ●○○
    4-FMA
    75% ●○○
    Methylphenidate
    75% ●○○

    Legal Status

    Country Status Notes
    Canada Schedule I (CDSA) Controlled since 1996 as an analogue of methamphetamine under the Controlled Drugs and Substances Act. Manufacturing, possession, and distribution are prohibited.
    China Controlled Designated a controlled substance in October 2015. Production, sale, and possession are prohibited under national drug control regulations.
    France Not explicitly scheduled As of December 2024, 2-FMA is not specifically listed in French drug schedules. Possession exists in a legal grey area, though this status could change.
    Germany Anlage I BtMG Listed under Anlage I of the Betäubungsmittelgesetz (Narcotics Act, Schedule I) since December 13, 2014. Manufacturing, possession, import, export, purchase, sale, procurement, and dispensing without a license are illegal. Violations are punishable by fines or imprisonment up to five years.
    Netherlands Legal (grey area) Currently unscheduled, though it falls within a substance group that may be subject to prohibition under recently passed New Psychoactive Substances legislation.
    New Zealand Schedule 3 Controlled as an amphetamine analogue under the Misuse of Drugs Act. Possession, supply, and manufacture carry criminal penalties.
    Switzerland Controlled (Verzeichnis E) Specifically named under Verzeichnis E of Swiss controlled substances regulations. Unauthorized possession and distribution are prohibited.
    Turkey Illegal Classified as a controlled drug. Possession, production, supply, and importation are prohibited under Turkish drug legislation.
    Ukraine Narcotic (controlled) Classified as a narcotic substance since July 2019. Possession, distribution, and production are illegal under Ukrainian law.
    United Kingdom Class A Controlled under the amphetamine analogue clause of the Misuse of Drugs Act 1971. Class A substances carry the most severe penalties, including up to seven years imprisonment for possession and life imprisonment for supply.
    United States Unscheduled Not specifically scheduled under the Controlled Substances Act. However, as a close structural analogue of methamphetamine, sale or possession with intent for human consumption could potentially be prosecuted under the Federal Analogue Act.
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