Substance: 2-ME-DMT Experience: 1st Time Setting: At home, Alone Administration: Nasal, Oral Gender: Male Age: 19 22:34 Snorted a small line to see if this stuff works nasally and perhaps works better this way. Doesn't burn badly but it is felt. I'm talking on msn and I'm basically in a good mood. Drip just started.
2-Me-DMT
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- classified Tentative
- classified Research-chemical
Aliases: 2,n,n-tmt, 2,n,n-trimethyltryptamine
Summary
2-Me-DMT is a rarely studied Shulgin-synthesized tryptamine notable for pronounced auditory distortion and pitch-shifting effects beginning at moderate doses. Unlike classical psychedelics, it produces minimal to no visual effects but instead causes tactile enhancement and sexual stimulation. The 2-methyl substitution blocks MAO metabolism allowing oral activity, but also dramatically reduces affinity for 5-HT2A receptors responsible for classical psychedelic effects.
Perspectives
“There was tingling everywhere but it faded after about three hours. Nothing else.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 30-50mg | 50-75mg | 75-100mg | 100mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 60-90 min | 1-3 hrs | 1-3 hrs | 3-8 hrs |
| Insufflated | 10-30 min | 1-3 hrs | 1-3 hrs | 3-8 hrs |
| Vaporized | 0-2 min | 5-15 min | 10-20 min | 15-37 min |
Effect Profile
1 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
3.4
Light+
3/10
Mild auditory effects with low visuals, headspace, and body load
Visual Intensity
×3
3
drifting
brightened colour
Headspace Depth
×3
2
confusion
time distortion
Auditory Effects
×1
4
auditory distortion
Body Load / Somatic Effects
×1
2
muscle tension
Stimulant
3.0
Light+
3/10
Moderate euphoria with mild anxiety/jitters, low stimulation
Stimulation / Energy
×3
2
cognitive stimulation
Euphoria / Mood Lift
×2
6
physical euphoria
euphoria
Focus / Productivity
×2
0
Anxiety / Jitters
×1
4
restlessness
muscle tension
Based on reports from:
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Name
2-Me-DMT
Unit
mg
Description
2-Me-DMT Source: SubstanceSearch (substancesearch.com) Oral dose (mg): light 30-50 · common 50-75 · strong 75-100 · heavy 100+ Insufflated dose (mg): threshold 5 Vaporized dose (mg): threshold 2 Oral duration: onset 1-1.5h · peak 1-3h · offset 1-3h · total 3-8h · after-effects 1-5h Insufflated duration: onset 10-30m · peak 1-3h · offset 1-3h · total 3-8h · after-effects 1-5h Vaporized duration: onset 0-2m · peak 5-15m · offset 10-20m · total 15-37m · after-effects 1-5h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 62.5 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Build-up
develops rapidly after a single use
Reset
7–14 days for baseline
Tolerance Decay
Half tolerance
7d
Baseline
~14d
Pattern modeled on classic serotonergic psychedelics: rapid tolerance accrual after a full experience and decay over 1–2 weeks. Evidence is indirect (TIHKAL, general psychedelic literature) rather than 2-Me-DMT–specific.
Cross-Tolerances
Effects
Positive
- Physical euphoria
- Cognitive stimulation
- Mental/physical stimulation
Negative
- Mild nausea
- Insomnia post-experience
- Pupil dilation
- Restlessness
- Sweating/chills
- Muscle tension
- Insomnia
- Bodily activation
- Dilated pupils
- Temperature dysregulation
- Decreased appetite
Positive
- Mild relaxation
- Euphoria
- Empathy
- Insight
Negative
- Confusion
- Memory suppression
- Amnesia
- Change in perception
- Ego softening
- Time distortion
Positive
- Tactile enhancement
- Sexual enhancement
- Skin alertness
- Brightened colour
- Enhanced tactile sensation
Negative
- Tingling sensations
- Auditory pitch shifting
- Auditory distortion
- Closed/Open eye visuals
- Drifting
Combinations
Cross-Check 2-Me-DMT with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 1 report 1 positive visit
PiHKAL / TiHKAL
TiHKAL #34: 2-Me-DMT
“There was tingling everywhere but it faded after about three hours. Nothing else.”
2-Me-DMT's nerd page
Pharmacology, chemical data, effect profiles, and more
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