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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2-Me-DMT

    Aliases: 2,n,n-tmt, 2,n,n-trimethyltryptamine

    Psychedelic Stimulant Research-chemical

    Summary TheDrug.Wiki TripSit

    2-Me-DMT is a rarely studied Shulgin-synthesized tryptamine notable for pronounced auditory distortion and pitch-shifting effects beginning at moderate doses. Unlike classical psychedelics, it produces minimal to no visual effects but instead causes tactile enhancement and sexual stimulation. The 2-methyl substitution blocks MAO metabolism allowing oral activity, but also dramatically reduces affinity for 5-HT2A receptors responsible for classical psychedelic effects.

    Perspectives

    “There was tingling everywhere but it faded after about three hours. Nothing else.”

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 30-50mg 50-75mg 75-100mg 100mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Peak Offset After Effects Total
    Oral 60-90 min 1-3 hrs 1-3 hrs 1-5 hrs 3-7.5 hrs
    Insufflated 10-30 min 1-3 hrs 1-3 hrs 1-5 hrs 2.2-6.5 hrs

    Effect Profile

    1 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 3.4
    Light+ 3/10

    Mild auditory effects with low visuals, headspace, and body load

    Visual Intensity ×3
    3
    drifting brightened colour
    Headspace Depth ×3
    2
    confusion time distortion
    Auditory Effects ×1
    4
    auditory distortion
    ⚠ Body Load / Somatic Effects ×1
    2
    muscle tension
    Stimulant 3.0
    Light+ 3/10

    Moderate euphoria with mild anxiety/jitters, low stimulation

    Stimulation / Energy ×3
    2
    cognitive stimulation
    Euphoria / Mood Lift ×2
    6
    physical euphoria euphoria
    Focus / Productivity ×2
    0
    ⚠ Anxiety / Jitters ×1
    4
    restlessness muscle tension
    Based on reports from:
    TiHKAL TiHKAL #34: 2-Me-DMT Erowid Experience Reports PsychonautWiki 2-Me-DMT
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 0h Half tolerance 3d Baseline ~7d

    Pattern modeled on classic serotonergic psychedelics: rapid tolerance accrual after a full experience and decay over 1–2 weeks. Evidence is indirect (TIHKAL, general psychedelic literature) rather than 2-Me-DMT–specific.

    Cross-Tolerances

    LSD
    50%
    Psilocybin/psilocin
    60%
    DMT
    50%

    Effects TheDrug.Wiki TripSit

    Positive
    • Physical euphoria
    • Cognitive stimulation
    • Mental/physical stimulation
    Negative
    • Mild nausea
    • Insomnia post-experience
    • Pupil dilation
    • Restlessness
    • Sweating/chills
    • Muscle tension
    • Insomnia
    Neutral
    • Bodily activation
    • Dilated pupils
    • Temperature dysregulation
    • Decreased appetite
    Positive
    • Mild relaxation
    • Euphoria
    • Empathy
    • Insight
    Negative
    • Confusion
    • Memory suppression
    • Amnesia
    Neutral
    • Change in perception
    • Ego softening
    • Time distortion
    Positive
    • Tactile enhancement
    • Sexual enhancement
    • Skin alertness
    • Brightened colour
    • Enhanced tactile sensation
    Negative
    • Tingling sensations
    Neutral
    • Auditory pitch shifting
    • Auditory distortion
    • Closed/Open eye visuals
    • Drifting

    Combinations TripSit

    PiHKAL / TiHKAL Shulgin

    TiHKAL #34: 2-Me-DMT

    “There was tingling everywhere but it faded after about three hours. Nothing else.”

    — Alexander Shulgin, TiHKAL (with 50 mg, orally)
    2-Me-DMT's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 TripSit 📖 PsychonautWiki