2-Me-DMT
Aliases: 2,n,n-tmt, 2,n,n-trimethyltryptamine
Categories
Summary
2-Me-DMT is a rarely studied Shulgin-synthesized tryptamine notable for pronounced auditory distortion and pitch-shifting effects beginning at moderate doses. Unlike classical psychedelics, it produces minimal to no visual effects but instead causes tactile enhancement and sexual stimulation. The 2-methyl substitution blocks MAO metabolism allowing oral activity, but also dramatically reduces affinity for 5-HT2A receptors responsible for classical psychedelic effects. Users report unpredictable dose-response; starting low and titrating upward on separate sessions is advised. Combining with MAOIs or stimulants increases physiological risk.
Perspectives
“There was tingling everywhere but it faded after about three hours. Nothing else.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 30-50mg | 50-75mg | 75-100mg | 100mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|
| Oral | 60-90 min | 1-3 hrs | 1-3 hrs | 1-5 hrs | 180-0 min |
| Insufflated | 10-30 min | 1-3 hrs | 1-3 hrs | 1-5 hrs | 180-0 min |
| Vaporized | 0-2 min | 5-15 min | 10-20 min | 1-5 hrs | 180-0 min |
Tolerance
Effects
- Physical euphoria
- Cognitive stimulation
- Mental/physical stimulation
- Mild nausea
- Insomnia post-experience
- Pupil dilation
- Restlessness
- Sweating/chills
- Muscle tension
- Insomnia
- Bodily activation
- Dilated pupils
- Temperature dysregulation
- Decreased appetite
- Mild relaxation
- Euphoria
- Empathy
- Insight
- Confusion
- Memory suppression
- Amnesia
- Change in perception
- Ego softening
- Time distortion
- Tactile enhancement
- Sexual enhancement
- Skin alertness
- Brightened colour
- Enhanced tactile sensation
- Tingling sensations
- Auditory pitch shifting
- Auditory distortion
- Closed/Open eye visuals
- Drifting
Combinations
PiHKAL / TiHKAL
“There was tingling everywhere but it faded after about three hours. Nothing else.”