2-MMC
Aliases: Ortho, 2-methyl mc, Orthophedrone, Orthomephedrone, 2mmc, ortomephedrone, 2-methylmethcathinone, 2methylmethcathinone, 2-mephedrone
Categories
Summary
• Pharmacology: In vitro data show 2-MMC acts as a serotonin-norepinephrine-dopamine releasing agent with higher affinity for DAT and NET than SERT, producing more "amphetaminic" stimulation with comparatively modest entactogenic warmth compared to 3-MMC or mephedrone (Eshleman 2013; Brandt 2020). 2-Substituted cathinones are generally weaker than their 3- and 4-substituted counterparts. • Compared with positional isomers 3-MMC and 4-MMC, 2-MMC is regarded as less euphoric but more focused/functional. Oral dosing best preserves euphoria; insufflation is notably harsh (users report 8-8.5/10 pain scale) and shorter-lived. • Common acute adverse effects: tachycardia, vasoconstriction (cold extremities, erectile dysfunction), jaw clenching, anxiety at peaks, and strong urge to redose every 1-2 hours. The comedown is often reported as smoother than other cathinones. • High or repeated doses can provoke confusion, visual disturbances (nystagmus), difficulty urinating, and in rare cases brief psychotic reactions; stay hydrated, monitor body temperature, and limit session length. • Harm-reduction: Use a 0.001g scale; allow at least 2 hours before considering a booster. Avoid combining with other stimulants or MAO-inhibiting substances.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 20-50mg | 50-100mg | 100-135mg | 135mg+ |
| Insufflated | 5-15mg | 15-40mg | 40-80mg | 80mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 20-45 min | 30-60 min | 1-2 hrs | 1-2 hrs | 2-8 hrs |
| Insufflated | 1-5 min | 5-15 min | 1-2 hrs | 1-2 hrs | 2-8 hrs |
| Rectal | 10-20 min | 20-40 min | 1-2 hrs | 1-2 hrs | 2-8 hrs |
Tolerance
Effects
- Stimulation
- Increased energy
- Bruxism & jaw tension
- Vasoconstriction & cold extremities
- Sweating
- Insomnia
- Dry mouth
- Increased heart rate
- Difficulty urinating
- Mouth numbing
- Motivation enhancement
- Euphoria
- Empathy & sociability
- Cognitive enhancement
- Analysis enhancement
- Mood lift
- Anxiety
- Compulsive redosing
- Memory suppression
- Crash: fatigue & low mood
- Talkativeness
- Time compression
- Sexual arousal & increased libido
- Music appreciation enhancement
- Tactile enhancement
- Increased libido
- Increased music appreciation
- Appetite suppression
- Light sensitivity
- Dehydration
- Disinhibition
- Vibrating vision