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    2-NMC molecular structure

    2-NMC Stats & Data

    Bmapn Βk-methamnetamine
    NPS DataHub
    MW213.28
    FormulaC14H15NO
    IUPAC2-(methylamino)-1-naphthalen-2-ylpropan-1-one
    SMILESCNC(C)C(=O)c1ccc2ccccc2c1
    InChIKeyQIMNQDXLKHGANJ-UHFFFAOYSA-N
    Phenethylamines; 2020/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2021/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2022/1. Von 2-Phenethylamin abgeleitete Verbindungen
    Chemical Class Cathinone
    Psychoactive Class Stimulant
    Half-Life Estimated 2 – 3 h in humans (based on structural analogues and limited in‑vitro hepatic microsome data)

    Receptor Profile

    Receptor Actions

    Inhibitors
    Dopamine-norepinephrine reuptake inhibitor
    Modulators
    Dopamine transporter modulator (decreases DAT expression, increases DAT phosphorylation)

    Effect Profile

    Curated
    Empathogen 3.3

    Mild stimulation with low empathy, euphoria, and sensory enhancement

    Empathy / Social Openness×3
    3
    Euphoria / Mood Elevation×2
    3
    Stimulation×1
    5
    Sensory Enhancement×1
    3
    Stimulant 2.4

    Strong anxiety/jitters with mild euphoria, low stimulation

    Stimulation / Energy×3
    3
    Euphoria / Mood Lift×2
    5
    Focus / Productivity×2
    0
    Anxiety / Jitters×1
    10

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Estimated 2 – 3 h in humans (based on structural analogues and limited in‑vitro hepatic microsome data)
    Addiction Potential
    Moderate-to-high. Animal data are lacking, but the compound’s mechanism (monoamine re-uptake inhibition/release) and human case reports show strong reinforcement, rapid tolerance, compulsive re-dosing and binge patterns similar to 3-MMC and mephedrone.

    Tolerance Decay

    Full tolerance 1d Half tolerance 3d Baseline ~7d

    Based on stimulant cross‑tolerance heuristics and user reports; frequent redosing within a day rapidly diminishes effects. Allow at least 1–2 weeks between sessions for baseline sensitivity to return.

    Cross-Tolerances

    Other cathinones (e.g., 3‑MMC, 4‑MMC)
    70% ●○○
    Amphetamines
    50% ●○○
    MDMA
    40% ●○○

    Harm Reduction

    drugs.wiki

    • Synthetic cathinones are often mis‑sold or used to adulterate other stimulants; EUDA explicitly notes mis‑selling of cathinones as amphetamine/MDMA/cocaine. Use multi‑reagent testing and—ideally—laboratory drug checking to confirm identity and detect adulterants.

    • Virtually no controlled pharmacology on 2‑NMC; harm profile inferred from close analogues (e.g., mephedrone, 3‑MMC) and user reports. Expect dopamine/noradrenaline transporter inhibition > serotonin, implying euphoria with significant cardiovascular strain.

    • Hyperthermia, dehydration, and hyponatraemia are documented risks with empathogenic cathinones; prefer small, regular sips of isotonic fluids and salty snacks rather than excessive water. Take cool‑down breaks away from heat and vigorous activity.

    • Repeated or high cumulative dosing increases vasoconstriction risk (cold/blue extremities), blood pressure elevation, and chest discomfort; seek medical care for chest pain, confusion, or overheating.

    • Nasal use causes notable mucosal irritation for many cathinones; oral dosing is less locally damaging and often smoother. If snorting, use tiny lines and saline rinse afterward.

    • Vaporizing unknown powders increases exposure to irritating/unknown pyrolysis products and can drive compulsive redosing; avoid when possible.

    • Compulsive redosing and sleep loss markedly amplify anxiety, paranoia and psychosis risk; set a firm session cap, stop redosing at least 6–8 h before planned sleep, and prioritize recovery nutrition, electrolytes, and sleep hygiene.

    • Because mislabeling of “3‑MMC/4‑MMC” as other cathinones is common in current markets, do not assume subjective effects confirm identity—lab results regularly reveal substitutions (e.g., 2‑MMC, 3‑CMC, dipentylone).

    References

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