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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2-TFMXP Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 3 ROAs with full dose ladders
    • duration data present
    • 18 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: 2-tfm-mxp

    Dissociative Research-chemical

    Summary TheDrug.Wiki

    2-TFMXP is the 2-trifluoromethyl analogue of methoxphenidine (MXP). Very little formal pharmacology is published; all dosing is extrapolated from user reports and structural activity relationships. Compared with MXP it appears 1.5-2× more potent and noticeably more stimulating with increased mania potential.

    Dose Information TheDrug.Wiki

    ROA Light Common Strong Heavy
    Oral 10-25mg 25-45mg 45-70mg 70mg+
    Sublingual 8-20mg 20-40mg 40-60mg 60mg+
    Insufflated 5-15mg 15-30mg 30-45mg 45mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects Total
    Oral 20-60 min 1.5-4 hrs 2-4 hrs 24 hrs 6-10 hrs
    Sublingual - 1.5-4 hrs 2-4 hrs 24 hrs 6-10 hrs
    Insufflated 20-60 min 1.5-4 hrs 2-4 hrs 24 hrs 6-10 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Dissociative 6.0
    Strong 6/10

    Strong dissociative depth and motor impairment with mild mania, low insight

    Dissociative Depth ×3
    10
    depersonalization derealization consciousness disconnection tactile disconnection physical disconnection visual disconnection +3 more
    ⚠ Mania / Compulsion ×1
    4
    stimulation euphoria
    Insight / Novel Thought ×2
    3
    conceptual thinking
    ⚠ Motor / Sensory Impairment ×1
    10
    motor control loss tactile disconnection physical disconnection tactile suppression numbness spatial disorientation +1 more
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 2-TFMXP
    View methodology →

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2–4 weeks for noticeable reduction

    Tolerance Decay

    Full tolerance 3d Half tolerance 14d Baseline ~28d

    Acute tolerance builds rapidly over hours to days, similar to other NMDA antagonists. After multi‑day use, a partial tolerance can persist for 1–2 weeks and typically returns near baseline by 4–6 weeks if abstinent. Data are from class analogs and user reports rather than formal studies.

    Cross-Tolerances

    Ketamine
    60%
    MXP (methoxphenidine)
    80%
    3‑MeO‑PCP/O‑PCE (arylcyclohexylamines)
    50%
    DXM
    40%

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    • Physical euphoria
    • Spontaneous tactile sensations
    • Pain relief
    Negative
    • Numbness
    • Loss of balance
    • Increased heart rate
    • Clumsiness in movement
    Neutral
    • Tactile disconnection
    • Physical disconnection
    Positive
    • Euphoria
    • Conceptual Thinking
    Negative
    • Depersonalization
    • Derealization
    • Motor Control Loss
    • Memory Suppression
    • Anxiety
    Neutral
    • Time Distortion
    • Consciousness Disconnection
    • Dissociation
    Positive
    • Perception of Bodily Lightness
    • Increased Music Appreciation
    • Perception of bodily lightness
    Negative
    • Tactile Suppression
    • Spatial Disorientation
    • Tactile suppression
    Neutral
    • Visual Disconnection
    • Internal Hallucination
    • Visual disconnection
    • Internal hallucinations

    Combinations TripSit

    Cross-Check 2-TFMXP with another substance

    2-TFMXP's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki