2-TFMXP
Aliases: 2-tfm-mxp
Summary
2-TFMXP is the 2-trifluoromethyl analogue of methoxphenidine (MXP). Very little formal pharmacology is published; all dosing is extrapolated from user reports and structural activity relationships. Compared with MXP it appears 1.5-2× more potent and noticeably more stimulating with increased mania potential.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | - | - | - | 70+mg(NOTRECOMMENDED)+ |
| Sublingual | - | - | - | 60+mg(NOTRECOMMENDED)+ |
| Insufflated | - | - | - | 45+mg(NOTRECOMMENDED)+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral | 20-60 min | 30-60 min | 1.5-4 hrs | 2-4 hrs |
| Sublingual | 10-30 min | 20-45 min | 1.5-4 hrs | 2-4 hrs |
| Insufflated | 5-15 min | 15-30 min | 1.5-4 hrs | 2-4 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Dissociative
6.0
Strong
6/10
Strong dissociative depth and motor impairment with mild mania, low insight
Dissociative Depth
×3
10
depersonalization
derealization
consciousness disconnection
tactile disconnection
physical disconnection
visual disconnection
+3 more
Mania / Compulsion
×1
4
stimulation
euphoria
Insight / Novel Thought
×2
3
conceptual thinking
Motor / Sensory Impairment
×1
10
motor control loss
tactile disconnection
physical disconnection
tactile suppression
numbness
spatial disorientation
+1 more
Based on reports from:
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2–4 weeks for noticeable reduction
Tolerance Decay
Full tolerance
3d
Half tolerance
14d
Baseline
~28d
Acute tolerance builds rapidly over hours to days, similar to other NMDA antagonists. After multi‑day use, a partial tolerance can persist for 1–2 weeks and typically returns near baseline by 4–6 weeks if abstinent. Data are from class analogs and user reports rather than formal studies.
Cross-Tolerances
Effects
Positive
- Stimulation
- Physical euphoria
- Spontaneous tactile sensations
- Pain relief
Negative
- Numbness
- Loss of balance
- Increased heart rate
- Clumsiness in movement
- Tactile disconnection
- Physical disconnection
Positive
- Euphoria
- Conceptual Thinking
Negative
- Depersonalization
- Derealization
- Motor Control Loss
- Memory Suppression
- Anxiety
- Time Distortion
- Consciousness Disconnection
- Dissociation
Positive
- Perception of Bodily Lightness
- Increased Music Appreciation
- Perception of bodily lightness
Negative
- Tactile Suppression
- Spatial Disorientation
- Tactile suppression
- Visual Disconnection
- Internal Hallucination
- Visual disconnection
- Internal hallucinations
Combinations
2-TFMXP's nerd page
Pharmacology, chemical data, effect profiles, and more
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