Summary
25E-NBOH first appeared on Brazilian blotters in 2018 and is now encountered worldwide in the microgram range. Laboratory seizure papers contain 290-820 ug per 6 mm blotter, often hot-spotted. The molecule is heat- and acid-labile; oral swallowing destroys most activity, so users hold tabs under the tongue for 15-30 minutes. Forum reports describe pronounced open-eye patterning, saturated color shifts and a phenethylamine-style body euphoria that peaks earlier than LSD. A 2023 French toxicology case linked 25E-NBOH (blotter) plus the stimulant MDPHP to serotonin syndrome and loss of consciousness requiring ICU admission, illustrating how co-ingestion magnifies risk.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Sublingual / Buccal (Blotter) | 15-45 min | 30-60 min | 2-4 hrs | 1-3 hrs | 1-12 hrs |
| Insufflated | 5-15 min | 20-40 min | 2-4 hrs | 1-3 hrs | 1-12 hrs |
| Vaporized / Smoked (Free Base) | 1-2 min | 5-15 min | 2-4 hrs | 1-3 hrs | 1-12 hrs |
Tolerance
Build-up
develops rapidly after a single use (serotonergic psychedelic)
Reset
7–14 days for baseline
Effects
Positive
- Stimulation
- Physical euphoria
- Creativity enhancement
Negative
- Temperature regulation suppression
- Nausea
- Pupil dilation
- Increased heart rate
- Increased blood pressure
- Increased perspiration
- Seizure
- Teeth grinding
- Spontaneous bodily sensations
- Frequent urination
- Muscle contractions
Positive
- Analysis enhancement
- Empathy enhancement
- Sociability enhancement
- Conceptual thinking
- Emotion enhancement
- Thought connectivity
- Empathy, affection and sociability enhancement
- Novelty enhancement
- Unity and interconnectedness
- Wakefulness
- Immersion intensification
Negative
- Memory suppression
- Time distortion
- Machinescapes
- Thought acceleration
- Personal bias suppression
- Existential self-realization
- Emotion intensification
- Spirituality intensification
Positive
- Tactile enhancement
- Pattern recognition enhancement
- Color enhancement
- Visual acuity enhancement
- Color shifting
- Tracers
- Increased music appreciation
- Synaesthesia
- Increased libido
- Bodily control enhancement
- Auditory acuity enhancement
Negative
- Dehydration
- Drifting
- Symmetrical texture repetition
- After images
- Internal hallucination
- Perspective hallucinations
- Auditory hallucination
- Auditory distortion
- Scenery slicing
- Perspective hallucination
- Tactile intensification