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    ☢ This substance has an extremely narrow safety margin. Small dosing errors can lead to life-threatening effects.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    25E-NBOH

    Aliases: 2c-e-nboh, Nboh-2c-e

    Psychedelic Stimulant Research-chemical

    Summary TheDrug.Wiki PsychonautWiki

    25E-NBOH first appeared on Brazilian blotters in 2018 and is now encountered worldwide in the microgram range. Laboratory seizure papers contain 290-820 ug per 6 mm blotter, often hot-spotted. The molecule is heat- and acid-labile; oral swallowing destroys most activity, so users hold tabs under the tongue for 15-30 minutes.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Comeup Peak Offset After Effects
    Sublingual / Buccal (Blotter) 15-45 min 30-60 min 2-4 hrs 1-3 hrs 1-12 hrs
    Insufflated 5-15 min 20-40 min 2-4 hrs 1-3 hrs 1-12 hrs
    Vaporized / Smoked (Free Base) 1-2 min 5-15 min 2-4 hrs 1-3 hrs 1-12 hrs

    Effect Profile

    10 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 8.2
    Intense 8/10

    Strong visuals, auditory effects, headspace, and body load

    Visual Intensity ×3
    10
    color enhancement drifting tracers synaesthesia pattern recognition enhancement color shifting +3 more
    Headspace Depth ×3
    8
    conceptual thinking thought connectivity emotion enhancement personal bias suppression time distortion
    Auditory Effects ×1
    10
    auditory distortion auditory hallucination synaesthesia
    ⚠ Body Load / Somatic Effects ×1
    8
    temperature regulation suppression nausea teeth grinding increased heart rate
    Stimulant 4.2
    Moderate 4/10

    Mild stimulation, anxiety/jitters, and focus with low euphoria

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    3
    physical euphoria
    Focus / Productivity ×2
    4
    analysis enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    5
    increased heart rate teeth grinding
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 25E-NBOH
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use (serotonergic psychedelic)
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Effects Erowid

    Aggregated from 10 Erowid experience reports

    Positive Effects 6

    Music Enhancement 80.0% 70%
    Stimulation 70.0% 70%
    Euphoria 60.0% 70%
    Color Enhancement 50.0% 70%
    Focus Enhancement 40.0% 70%
    Tactile Enhancement 30.0% 70%

    Adverse Effects 5

    Nausea 40.0% 70%
    Anxiety 40.0% 70%
    Muscle Tension 40.0% 70%
    Pupil Dilation 30.0% 70%
    Confusion 30.0% 70%

    Combinations TripSit

    25E-NBOH's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki