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    ☢ This substance has an extremely narrow safety margin. Small dosing errors can lead to life-threatening effects.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    25E-NBOH Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 3 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 19 combo interactions documented
    • toxicity data (PsychonautWiki)
    • classified Research-chemical

    Aliases: 2c-e-nboh, Nboh-2c-e

    Psychedelic Stimulant Research-chemical

    Summary dose.wiki PsychonautWiki

    25E-NBOH first appeared on Brazilian blotters in 2018 and is now encountered worldwide in the microgram range. Laboratory seizure papers contain 290-820 ug per 6 mm blotter, often hot-spotted. The molecule is heat- and acid-labile; oral swallowing destroys most activity, so users hold tabs under the tongue for 15-30 minutes.

    Dose Information dose.wiki

    ROA Light Common Strong Heavy
    Sublingual / Buccal (Blotter) 200-600µg 600-1000µg 1000-1200µg 1200µg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Sublingual / Buccal (Blotter) 15-45 min 30-60 min 2-4 hrs 1-3 hrs 1-12 hrs 3.75-8.75 hrs
    Insufflated 5-15 min 20-40 min 2-4 hrs 1-3 hrs 1-12 hrs 3.41-7.92 hrs
    Vaporized / Smoked (Free Base) 1-2 min 5-15 min 2-4 hrs 1-3 hrs 1-12 hrs 3.09-7.28 hrs

    Effect Profile

    10 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 8.2
    Intense 8/10

    Strong visuals, auditory effects, headspace, and body load

    Visual Intensity ×3
    10
    color enhancement drifting tracers synaesthesia pattern recognition enhancement color shifting +3 more
    Headspace Depth ×3
    8
    conceptual thinking thought connectivity emotion enhancement personal bias suppression time distortion
    Auditory Effects ×1
    10
    auditory distortion auditory hallucination synaesthesia
    ⚠ Body Load / Somatic Effects ×1
    8
    temperature regulation suppression nausea teeth grinding increased heart rate
    Stimulant 4.2
    Moderate 4/10

    Mild stimulation, anxiety/jitters, and focus with low euphoria

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    3
    physical euphoria
    Focus / Productivity ×2
    4
    analysis enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    5
    increased heart rate teeth grinding
    Based on reports from:
    Erowid Experience Reports
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 25E-NBOH there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    Name
    25E-NBOH
    Unit
    µg
    Description 
    25E-NBOH
Source: SubstanceSearch (substancesearch.com)

Sublingual / Buccal (Blotter) dose (µg): threshold 100ug · light 200-600 · common 600-1000 · strong 1000-1200 · heavy 1200+
Insufflated dose (µg): threshold 50ug
Vaporized / Smoked (Free Base) dose (µg): threshold 50ug

Sublingual / Buccal (Blotter) duration: onset 15-45m · come-up 0.5-1h · peak 2-4h · offset 1-3h · total 3.75-8.75h · after-effects 1-12h
Insufflated duration: onset 5-15m · come-up 20-40m · peak 2-4h · offset 1-3h · total 3.41-7.92h · after-effects 1-12h
Vaporized / Smoked (Free Base) duration: onset 1-2m · come-up 5-15m · peak 2-4h · offset 1-3h · total 3.09-7.28h · after-effects 1-12h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 800 µg (Sublingual / Buccal (Blotter)).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Effects Erowid

    Aggregated from 10 Erowid experience reports

    Positive Effects 6

    Music Enhancement 80.0% 70%
    Stimulation 70.0% 70%
    Euphoria 60.0% 70%
    Color Enhancement 50.0% 70%
    Focus Enhancement 40.0% 70%
    Tactile Enhancement 30.0% 70%

    Adverse Effects 5

    Nausea 40.0% 70%
    Anxiety 40.0% 70%
    Muscle Tension 40.0% 70%
    Pupil Dilation 30.0% 70%
    Confusion 30.0% 70%

    Combinations

    Cross-Check 25E-NBOH with another substance

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

    Erowid 8 reports 1 positive 4 neutral 3 cautionary visit
    Manageable Magic positive exp #113155

    1.8mg of 25E-NBOH was ingested at 6:10AM morning. Last psychedelic taken was 2C-B-FLY, three weeks ago. No other drugs used in the previous three weeks, or during the 25E-NBOH experience.

    Caltrain208 · 1.8 mg oral
    An Extensive Review cautionary exp #116586

    An Extensive Review: 25E-NBOH S : Male Age : 25-27 yo Weight : 81-87kg (at the time of the experiences) Height : 1.83m Athletic Experienced with mind altering substances, previous experiences with psychedelics (tryptamines, lysergamides, phenethylamines), stimulants (amphetamines and derivatives, MDMA, coke, methylphen...

    StandardSiren
    Unsettling and Disturbing cautionary exp #114995

    [Erowid Note: The dose described in this report is very high, potentially beyond Erowid's 'heavy' range, and could pose serious health risks or result in unwanted, extreme effects.

    Diddly Dankwurter
    Unpleasant cautionary exp #114358

    Unpleasant First Experience This was my first time with any phenethylamine, my previous hallucinogenic experiences have consisted of shrooms, lsd, salvia, dxm, dph, weed, and nutmeg. The only recent experience from the time of this trip was a few weeks prior with mushrooms.

    Jill Stingray · 600 ug sublingual
    A Bit Hot at Times neutral exp #115959

    Setting: Alone in my room just playing guitar and listening to music This is my first time taking 25E-NBOH and this is a fairly unknown substance so there is no real obvious onset, comeup, peak, comedown knowledge and there is also very little known about the dosages.

    4054 · 1.8 mg sublingual
    Pleasant Trip at the Park neutral exp #113497

    Trip starts at 3:30PM when I take a tab of 25E-NBOH on the bus to the Imperial War Museum. This was done without a tolerance (no psychs had been used for the prior month). 0:00: A 2mg tab was injected sublingually. 0:25: Only a slight nausea.

    S · 2 mg sublingual
    After Exhaling I Just Got This Grin on My Face neutral exp #116768

    Vaping 25E-NBOH I read on the interwebs that you could vape this substance, so I ordered myself 500mg 25E-NBOH powder and dissolved it all in 10ml of pure PG, then diluted 1ml of the concentrate to 9ml of 50/50 VG/PG. The concentration of the complete product was about 4-5mg per ML.

    RtRD
    Mild Entactogenic Psychedelic/Side Effects neutral exp #115103

    I take 40mg d-amp split in 10mg 4x/day 500mg Phenibut 5x/day 2.0g kratom 4x/day Dependence on listed substances for 2 years (kratom and Phenibut) D-amp (8 years for ADHD) Presumably little impact on experience given the length of dependence on previous substances.

    UniversalDistillate · 1.5 mg buccal / 40 mg oral / 2.5 g oral / 8 g oral
    25E-NBOH's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki