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    25E-NBOMe molecular structure

    25E-NBOMe Stats & Data

    Psychedelic Research-chemical
    25e
    NPS DataHub
    MW329.44
    FormulaC20H27NO3
    CAS1354632-14-6
    IUPAC2-(4-ethyl-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine
    SMILESCOc1ccccc1CNCCc1cc(OC)c(CC)cc1OC
    InChIKeyPXDVGFGXPVCNAB-UHFFFAOYSA-N
    Phenethylamines; 2020/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2021/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2022/1. Von 2-Phenethylamin abgeleitete Verbindungen
    Chemical Class Phenethylamine
    Psychoactive Class Psychedelic

    History & Culture

    25E-NBOMe first appeared in scientific literature around 2012, emerging as part of the broader NBOMe series of substituted phenethylamines. This class of compounds, which includes related substances such as 25I-NBOMe and 25C-NBOMe, gained attention during this period as novel psychoactive substances. Following its initial scientific documentation, 25E-NBOMe subsequently appeared on the recreational drug market alongside other members of this chemical family.

    Effect Profile

    Curated + 3 Reports
    Psychedelic 2.8

    Moderate body load with mild visuals, low headspace

    Visual Intensity×3
    4
    Headspace Depth×3
    2
    Auditory Effects×1
    0
    Body Load / Somatic Effects×1
    6
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 25E-NBOMe

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Cross-Tolerances

    LSD
    60% ●○○
    Psilocybin
    65% ●○○
    Psilocin
    65% ●○○
    Mescaline
    85% ●○○
    DMT
    65% ●○○
    5-MeO-DMT
    65% ●○○
    2C-B
    85% ●○○
    2C-E
    85% ●○○

    Experience Report Analysis

    Erowid
    3 Reports
    2014–2022 Date Range
    3 With Age Data
    3 Effects Detected

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Effect Analysis

    Erowid

    Effects aggregated from 3 experience reports (3 Erowid)

    3 Reports
    3 Effects Detected
    1 Positive
    1 Adverse
    1 Neutral

    Effect Sentiment Distribution

    Confidence Distribution

    Positive Effects 1

    Color Enhancement 100.0% 70%

    Adverse Effects 1

    Anxiety 100.0% 70%

    Real-World Dose Distribution

    62K Doses

    From 5 individual dose entries

    Form / Preparation

    Most common forms and preparations reported

    Read full reports on Erowid →

    Legal Status

    Country Status Notes
    Sweden Narcotic substance Classified as a narcotic substance by Sweden's public health agency on January 18, 2019. This classification places it under the same regulatory framework as other controlled narcotics in Swedish law.
    United Kingdom Class A Controlled under the Misuse of Drugs Act 1971 through the N-benzylphenethylamine catch-all clause. Class A substances carry the most severe penalties, with possession punishable by up to 7 years imprisonment and supply offenses carrying maximum life sentences.
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