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    Disclaimer
    ☠ NBOMe compounds are active at sub-milligram doses and have been linked to numerous deaths. They are frequently mis-sold as LSD. Always test substances before use.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    25E-NBOMe Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 19 combo interactions documented
    • classified Research-chemical

    Aliases: 25e

    Psychedelic Research-chemical

    Summary TripSit

    A potent psychedelic phenethylamine and derivative of 2C-E, usually sold on blotters. May be mis-sold as LSD. Effects include vivid hallucinations, stimulation, heavy body load and vasoconstriction.

    Dose Information TripSit

    ROA Light Common Strong Heavy
    Sublingual 150-300ug 300-600ug 600-1000ug 1000ug+
    Insufflated 50-200ug 200-400ug 400-800ug 800µg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TripSit

    ROA Onset Peak After Effects Total
    Sublingual 15-60 min 5-10 hrs 2-10 hrs 5-10 hrs

    Effect Profile

    3 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 2.8
    Light+ 3/10

    Moderate body load with mild visuals, low headspace

    Visual Intensity ×3
    4
    color enhancement brightened colour visual distortions
    Headspace Depth ×3
    2
    confusion time distortion
    Auditory Effects ×1
    0
    ⚠ Body Load / Somatic Effects ×1
    6
    nausea muscle tension increased heart rate
    Based on reports from:
    Erowid Experience Reports
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 25E-NBOMe there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "25E-NBOMe (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    25E-NBOMe
    Unit
    µg
    Description 
    25E-NBOMe
Source: SubstanceSearch (substancesearch.com)

Sublingual dose (µg): threshold 50-100ug · light 150-300ug · common 300-600ug · strong 600-1000ug · heavy 1000ug+
Insufflated dose (µg): light 50-200ug · common 200-400ug · strong 400-800ug · heavy 800+

Sublingual duration: onset 0.25-1h · peak 5-10h · total 5-10h · after-effects 2-10h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 450 µg (Sublingual).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops rapidly after a single use; redosing is especially dangerous
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Cross-Tolerances

    Lysergamides
    LSD
    60%
    Tryptamines
    Psilocybin
    65%
    Psilocin
    65%
    DMT
    65%
    5-MeO-DMT
    65%
    Phenethylamines
    Mescaline
    85%
    2C-B
    85%
    2C-E
    85%

    Effects Erowid

    Aggregated from 3 Erowid experience reports

    Positive Effects 1

    Color Enhancement 100.0% 70%

    Adverse Effects 1

    Anxiety 100.0% 70%

    Combinations TripSit

    Cross-Check 25E-NBOMe with another substance

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

    Erowid 3 reports 2 neutral 1 cautionary visit
    What Time Is It... cautionary exp #112555

    - Dose: 400mcg (+/- 50mcg) - ROA: Nasal (via nasal spray bottle) - Set/setting: My home during a weekday, in good spirits. - Tolerance: Dosed 250mcg a week prior. It's 10am on a Monday, I had awoken an hour before with plans to trip today.

    HeadphonesandLSD · 1 smoked / 400 ug insufflated / smoked
    Exploring the NBOMes neutral exp #112554

    - Dose: 250mcg - ROA: Nasal (via nasal spray bottle) - Set/Setting: my home in a private bar/barn at the end of our property. My friend brought me the bottle late on this night, we had worked out a trade as we often do. It was my first attempt with an nbome as I'd avoided dosing them up until this point.

    HeadphonesandLSD · repeated insufflated / smoked
    Emotionally Intense neutral exp #116748

    This is my account of 25E-NBOMe. I have tried 25E-NBOH (a structurally similar substance) before at dosages ranging from 1.8mg to 3.6mg (I prefer 1.8mg overall) and I generally like that one a lot.

    TrippingArthur · 1.2 mg buccal
    25E-NBOMe's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 TripSit 📖 PsychonautWiki