25I-NBF
Aliases: 2c-i-nbf, Nbf-2c-i, Cimbi-21
Summary
25I-NBF is approximately 6-8 times less potent than 25I-NBOMe but shares a similar qualitative effect profile and comparable safety concerns. Primary activity occurs through potent partial agonism at 5-HT2A and 5-HT2C receptors with bias toward ฮฒ-arrestin 2 signaling; peripheral ฮฑ-adrenergic activity contributes to vasoconstriction and cardiovascular strain. Oral bioavailability is low; sublingual, buccal, or insufflated administration is typically used.
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Sublingual | 10-30 min | 30-60 min | 2-4 hrs | 2-4 hrs |
| Insufflated | 5-15 min | 20-45 min | 2-4 hrs | 2-4 hrs |
| Oral | 30-60 min | 45-90 min | 2-4 hrs | 2-4 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong visuals with moderate headspace and body load, mild auditory effects
Strong anxiety/jitters with moderate euphoria, low stimulation and focus
Tolerance
Tolerance Decay
Rapid tolerance build similar to NBOMe/LSD is reported anecdotally; noticeable tolerance persists several days and may take 1โ2 weeks to normalize.
Cross-Tolerances
Effects
- Stimulation
- Physical euphoria
- Increased heart rate
- Vasoconstriction
- Nausea
- Pupil dilation
- Insomnia
- Restlessness
- Sedation
- Spontaneous bodily sensations
- Euphoria
- Empathy
- Conceptual thinking
- Analysis enhancement
- Anxiety
- Confusion
- Thought loops
- Memory suppression
- Motor control loss
- Time distortion
- Colour enhancement
- Bodily control enhancement
- Tactile enhancement
- Color enhancement
- Tracers
- Increased music appreciation
- Visual patterning
- Closed-eye visuals
- Drifting
- Auditory distortion