25I-NBF
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Tentative
- classified Research-chemical
- 3 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Tentative
- classified Research-chemical
Aliases: 2c-i-nbf, Nbf-2c-i, Cimbi-21
Summary
25I-NBF (Cimbi-21) is a psychedelic phenethylamine and research chemical. It acts primarily through potent partial agonism at 5-HT2A and 5-HT2C receptors with bias toward ฮฒ-arrestin 2 signaling, while peripheral ฮฑ-adrenergic activity contributes to vasoconstriction and cardiovascular strain. It is approximately 6-8 times less potent than 25I-NBOMe but shares a similar qualitative effect profile and comparable safety concerns. Oral bioavailability is low, so sublingual, buccal, or insufflated administration is typically used.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Sublingual | 2-4mg | 4-8mg | 8-12mg | 12mg+ |
| Insufflated | 1-2mg | 2-5mg | 5-8mg | 8mg+ |
| Oral | 6-10mg | 10-16mg | 16-22mg | 22mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Sublingual | 10-30 min | 2-4 hrs | 2-4 hrs | 6-10 hrs |
| Insufflated | 10-30 min | 2-4 hrs | 2-4 hrs | 6-10 hrs |
| Oral | 10-30 min | 2-4 hrs | 2-4 hrs | 6-10 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong visuals with moderate headspace and body load, mild auditory effects
Strong anxiety/jitters with moderate euphoria, low stimulation and focus
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session โ the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Rapid tolerance build similar to NBOMe/LSD is reported anecdotally; noticeable tolerance persists several days and may take 1โ2 weeks to normalize.
Cross-Tolerances
Effects
- Stimulation
- Physical euphoria
- Increased heart rate
- Vasoconstriction
- Nausea
- Pupil dilation
- Insomnia
- Restlessness
- Sedation
- Spontaneous bodily sensations
- Euphoria
- Empathy
- Conceptual thinking
- Analysis enhancement
- Anxiety
- Confusion
- Thought loops
- Memory suppression
- Motor control loss
- Time distortion
- Colour enhancement
- Bodily control enhancement
- Tactile enhancement
- Color enhancement
- Tracers
- Increased music appreciation
- Visual patterning
- Closed-eye visuals
- Drifting
- Auditory distortion
Combinations
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