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    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    25I-NBOH Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 5 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 19 combo interactions documented
    • PubChem toxicity data
    • classified Tentative
    • classified Research-chemical

    Aliases: Cimbi-27, Nboh-2c-i, nboh-2ci

    Summary TheDrug.Wiki TripSit PsychonautWiki

    25I-NBOH (Cimbi-27, also known as NBOH-2C-I) is a psychedelic phenethylamine and research chemical, belonging to the hallucinogen class. It is approximately 2-3 times less potent than 25I-NBOMe but significantly more potent than 2C-I. It is not orally active and must be administered sublingually or buccally. Extreme vasoconstriction and cardiovascular strain have been reported at higher doses.

    Perspectives

    “I can’t really see any permanent psychedelic therapy uses for this one, as while it does fill the user with beautiful colorful empathy while it lasts, it eventually fades to the exact same state as before. I can say though, it had the most beautiful and intense visuals of any trip.”

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Sublingual 200-500Β΅g 500-900Β΅g 900-1400Β΅g 1400Β΅g+
    Buccal 200-500Β΅g 500-900Β΅g 900-1400Β΅g 1400Β΅g+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Sublingual 15-60 min 30-90 min 2-3.5 hrs 1.5-2.5 hrs 3-12 hrs 5-10 hrs
    Buccal 15-60 min 30-90 min 2-3.5 hrs 1.5-2.5 hrs 3-12 hrs 5-10 hrs

    Effect Profile

    12 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 8.4
    Intense 8/10

    Strong visuals, auditory effects, body load, and headspace

    Visual Intensity ×3
    10
    colour enhancement drifting tracers synaesthesia pattern recognition enhancement scenery slicing +6 more
    Headspace Depth ×3
    9
    conceptual thinking recursion emotion enhancement personal bias suppression time distortion confusion
    Auditory Effects ×1
    10
    auditory distortion auditory hallucination synaesthesia
    Body Load / Somatic Effects ×1
    10
    nausea temperature regulation suppression vasoconstriction muscle tension increased heart rate
    Stimulant 4.4
    Moderate 4/10

    Strong anxiety/jitters with moderate euphoria, mild stimulation and focus

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    6
    physical euphoria euphoria
    Focus / Productivity ×2
    4
    analysis enhancement thought acceleration
    Anxiety / Jitters ×1
    10
    anxiety restlessness paranoia increased heart rate vasoconstriction muscle tension

    Tolerance

    Build-up develops rapidly after a single use (serotonergic psychedelic)
    Reset 7–14 days for baseline

    Tolerance Decay

    Half tolerance 7d Baseline ~14d

    Rapid within-session tolerance typical of serotonergic psychedelics; redosing adds side effects with limited benefit. Return to baseline generally reported within 1–3 weeks.

    Effects Erowid

    Aggregated from 12 Erowid experience reports

    Positive Effects 10

    Color Enhancement 75.0% 70%
    Tactile Enhancement 58.3% 70%
    Music Enhancement 58.3% 70%
    Introspection 50.0% 70%
    Stimulation 50.0% 70%
    Euphoria 41.7% 70%
    Empathy 41.7% 70%
    Focus Enhancement 33.3% 70%
    Pain Relief 33.3% 70%
    Body High 33.3% 70%

    Adverse Effects 5

    Nausea 50.0% 70%
    Muscle Tension 50.0% 70%
    Anxiety 41.7% 70%
    Confusion 33.3% 70%
    Pupil Dilation 25.0% 70%

    Combinations TripSit

    Cross-Check 25I-NBOH with another substance

    Trip Reports Effect Index

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.

    Erowid 8 reports 1 positive 7 neutral visit
    A Pleasant Euphoric INTENSE Visual Trip positive exp #102786

    Prior drug experience - Cannabis, Alcohol, aMT, 2C-i, LSD, psilocybin, cocaine, salvia, amphetamine, MDMA, MDA I wrote this trip report in my notes in my iPhone through the entire trip, this is real-time reports. Duration: 8hrs 3pm - 9pm - 8-10 vape bags and 4 joints of chocolate cheesecake.

    Kerrnel · repeated smoked / 1 mg insufflated / 1 bowl smoked / .5 joints/cigs smoked
    Cold Shock neutral exp #110540

    T0:00- One tab in the mouth. Bitter taste, numbing flavor, pretty much like any NBOMe. T0:20- I can feel something building. ItΒ’s like there is buzzing through my body and energy is building throughout my veins.

    nervewing · 25i-NBOH · 1 mg sublingual / 1 bowl smoked
    Check Out That Wood Grain neutral exp #106249

    In the summer of 2014, the guy I was dating at the time managed to acquire a (in my opinion) ridiculous amount of NBOH 25i. During this time, I bore witness to a whole range of different reactions from friends and anyone he would sell to, as well as experimenting heavily myself.

    bethanybunny · oral
    Nice and Easy neutral exp #107750

    Background: I have little experience with psychedelics. Took shrooms/truffles 6 times since july 2015. And once LSD about 2 weeks ago. A few experiences with 2cb and one with 2cp sum this all up. So I know my deal with phens and tryptamines.

    hulu · 0.25 hits sublingual / 5 hits smoked / smoked
    A Wonderful Experience Even at a Low Dose neutral exp #102974

    Dose: 250ug 25i-NBOH, sublingual Setting: Alone in my room, calm. Slow to come on, about 1 hour of anticipation. T+1 A certain dizziness/vertigo emerges. Vision is blurred. I feel sleepy. T+1:30 Altered edge perception and some colour enhancement. Definite shimmering. Potential visuals in the periphery.

    Polar
    Light, Manageable and Potent neutral exp #104119

    Wonderful First Experience This is my first trip report, so I apologize for the possible lack of depth. I am 22 years old, I have a very large background in psychedelic drug usage among many other substances. I obtained the 25I-NBOH through a trusted vendor earlier in the week.

    Anonymous6589 · 2 hits / 2 hits / smoked / 6 hits
    Easier to Control but Lacking Depth neutral exp #102368

    25I-NBOH Test Trial 1 The first entry is written verbatim as I experienced the drug. The second is a timeline describing the effects. 2 grams of B+ strain Psilocybin mushrooms were consumed 24 hrs before. This shouldn't affect the trip, because psilo is metabolized rather quickly from my understanding.

    asthmatic · 500 mg sublingual / 500 mg sublingual
    An Emotional Fail neutral exp #105302

    Essentially I made a 25I-NBOH solution which should have turned out to be 1mg per ml, 22ml in total. I attempted the method you just squirt the known amount in your mouth and for me this would have been 1mg then leave it there for awhile and be done with it.

    NData · 1 mg sublingual

    Bluelight Reference Guide Bluelight

    Phenethylamines The Big and Dandy 25x-NBOH Megathread | Post your 25x-NBOH info and questions here.

    I thought it would be nice to have a spot where all of the various 25x-NBOH series can be discussed as a group or individually, questions can be answered, and information can be dispersed. Relate your usage and discuss!

    Read full thread on Bluelight β†’

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