25I-NBOH - Substance Search

Summary TheDrug.Wiki TripSit PsychonautWiki

25I-NBOH is approximately 2-3 times less potent than 25I-NBOMe but significantly more potent than 2C-I. Not orally active; must be administered sublingually or buccally. Extreme vasoconstriction and cardiovascular strain reported at higher doses.

Perspectives

“I can’t really see any permanent psychedelic therapy uses for this one, as while it does fill the user with beautiful colorful empathy while it lasts, it eventually fades to the exact same state as before. I can say though, it had the most beautiful and intense visuals of any trip.”

— Nervewing, nervewing.blogspot.com 1 mg sublingual

Dose Information TheDrug.Wiki TripSit PsychonautWiki

ROA	Light	Common	Strong	Heavy
Sublingual	200-500µg	500-900µg	900-1400µg	1400µg+
Buccal	200-500µg	500-900µg	900-1400µg	1400µg+
Oral	416ug-766	800-1400µg	1400ug-2000	2000µg+

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Sublingual	15-60 min	30-90 min	2-3.5 hrs	1.5-2.5 hrs	3-12 hrs	5-10 hrs
Buccal	15-60 min	30-90 min	2-3.5 hrs	1.5-2.5 hrs	3-12 hrs	4.2-8.5 hrs
Oral	19-45 min	30-90 min	2-3.5 hrs	1.5-2.5 hrs	3-12 hrs	5-10 hrs

Effect Profile

12 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Psychedelic 8.4

Intense 8/10

Strong visuals, auditory effects, body load, and headspace

Visual Intensity ×3

10

colour enhancement drifting tracers synaesthesia pattern recognition enhancement scenery slicing +6 more

Headspace Depth ×3

9

conceptual thinking recursion emotion enhancement personal bias suppression time distortion confusion

Auditory Effects ×1

10

auditory distortion auditory hallucination synaesthesia

⚠ Body Load / Somatic Effects ×1

10

nausea temperature regulation suppression vasoconstriction muscle tension increased heart rate

Stimulant 4.4

Moderate 4/10

Strong anxiety/jitters with moderate euphoria, mild stimulation and focus

Stimulation / Energy ×3

5

stimulation wakefulness

Euphoria / Mood Lift ×2

6

physical euphoria euphoria

Focus / Productivity ×2

4

analysis enhancement thought acceleration

⚠ Anxiety / Jitters ×1

10

anxiety restlessness paranoia increased heart rate vasoconstriction muscle tension

Based on reports from:

Effect Index Cold Shock Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki 25I-NBOH

Tolerance

Build-up develops rapidly after a single use (serotonergic psychedelic)

Reset 7–14 days for baseline

Tolerance Decay

Full tolerance 0h Half tolerance 7d Baseline ~14d

Rapid within-session tolerance typical of serotonergic psychedelics; redosing adds side effects with limited benefit. Return to baseline generally reported within 1–3 weeks.

Cross-Tolerances

Classical psychedelics (e.g., LSD, psilocybin)

70%

NBOMe series

80%

DOx series (e.g., DOC)

50%

Effects Erowid

Aggregated from 12 Erowid experience reports

Positive Effects 10

Color Enhancement 75.0% 70%

Tactile Enhancement 58.3% 70%

Music Enhancement 58.3% 70%

Introspection 50.0% 70%

Stimulation 50.0% 70%

Euphoria 41.7% 70%

Empathy 41.7% 70%

Focus Enhancement 33.3% 70%

Pain Relief 33.3% 70%

Body High 33.3% 70%

Adverse Effects 5

Nausea 50.0% 70%

Muscle Tension 50.0% 70%

Anxiety 41.7% 70%

Confusion 33.3% 70%

Pupil Dilation 25.0% 70%

Combinations TripSit

Trip Reports Effect Index

Cold Shock nervewing

25I-NBOH's nerd page Pharmacology, chemical data, effect profiles, and more

→

Helpful Links

📘 Experience Reports 📖 TheDrug.Wiki 📖 TripSit 📖 Bluelight 📖 PsychonautWiki