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    Disclaimer
    ☠ This substance has been associated with serious adverse events including fatalities. Use extreme caution.
    ☠ NBOMe compounds are active at sub-milligram doses and have been linked to numerous deaths. They are frequently mis-sold as LSD. Always test substances before use.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    25N-NBOMe Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 4 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 19 combo interactions documented
    • toxicity data (PsychonautWiki)
    • classified Tentative
    • classified Research-chemical

    Aliases: 25n, N-bomb, 2c-n-nbome, Nbome-2c-n, 2-c-n-nbome

    Psychedelic Research-chemical

    Summary dose.wiki TripSit PsychonautWiki

    25N-NBOMe is a highly potent and unpredictable substance that has been linked to numerous hospitalizations and fatalities within the NBOMe series. The compound must only be administered sublingually, as insufflation dramatically increases overdose risk and has been implicated in multiple deaths. Blotter papers may contain uneven dose distribution with dangerous hotspots.

    Dose Information dose.wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Sublingual 100-300µg 300-800µg 800-1300µg 1300ug+
    Buccal 100-300ug 300-800ug 800-1300ug 1300ug+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki TripSit PsychonautWiki

    ROA Onset Peak Offset After Effects Total
    Sublingual 45-75 min 2-3 hrs 2-3 hrs 5-10 hrs 5-10 hrs
    Buccal 45-75 min 5-10 hrs - 1-12 hrs 5-10 hrs

    Effect Profile

    2 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 7.5
    Intense 8/10

    Strong visuals, auditory effects, and body load with moderate headspace

    Visual Intensity ×3
    10
    internal hallucinations colour enhancement drifting synaesthesia pattern recognition enhancement brightened colour +1 more
    Headspace Depth ×3
    6
    conceptual thinking personal bias suppression time distortion confusion
    Auditory Effects ×1
    10
    auditory enhancement auditory distortion auditory hallucination synaesthesia
    ⚠ Body Load / Somatic Effects ×1
    8
    vasoconstriction nausea muscle tension increased heart rate
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 25N-NBOMe
    View methodology →

    Add missing routes to PsychonautWiki Journal

    The PsychonautWiki Journal app already has 25N-NBOMe, but its built-in entry only covers Sublingual. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.

    ⬇ Download import file Import this file as custom substances and you get "25N-NBOMe (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Custom Unit doses
    • Buccalcommon ~ 550 µg
    Dose & duration (reference) 
    25N-NBOMe: routes the PsychonautWiki Journal app is missing
Source: SubstanceSearch (substancesearch.com)

Buccal dose (µg): light 100-300ug · common 300-800ug · strong 800-1300ug · heavy 1300ug+

Buccal duration: onset 0.75-1.25h · peak 5-10h · total 5-10h · after-effects 1-12h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Custom Units carry a single dose per route, so the full ranges live in the reference above. A route's suggested dose is the midpoint of its common range. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Effects dose.wiki TripSit PsychonautWiki

    Positive
    • Stimulation
    • Mental/physical stimulation
    • Physical euphoria
    Negative
    • Abnormal Heartbeat
    • Increased Heart Rate
    • Increased Blood Pressure
    • Vasoconstriction
    • Muscle Tension
    • Nausea
    • Pupil Dilation
    • Restlessness
    • Sweating/chills
    • Insomnia
    • Headache
    • Muscle cramp
    • Stomach cramp
    • Runny nose
    • Seizure
    • Dry mouth
    Neutral
    • Mouth Numbing
    • Muscle Contractions
    • Decreased appetite
    • Difficulty urinating
    • Frequent urination
    • Restless legs
    • Spontaneous bodily sensations
    Positive
    • Analysis Enhancement
    • Conceptual Thinking
    • Empathy Enhancement
    • Sociability Enhancement
    • Euphoria
    • Empathy
    • Insight
    • Empathy, affection and sociability enhancement
    • Novelty enhancement
    • Unity and interconnectedness
    • Laughter fits
    • Wakefulness
    • Increased sense of humor
    • Immersion intensification
    Negative
    • Anxiety
    • Paranoia
    • Memory Suppression
    • Confusion
    • Thought deceleration
    • Amnesia
    Neutral
    • Thought Acceleration
    • Time Distortion
    • Change in perception
    • Ego softening
    • Personal bias suppression
    • Existential self-realization
    • Emotion intensification
    Positive
    • Perception Of Bodily Lightness
    • Tactile Enhancement
    • Bodily Control Enhancement
    • Colour Enhancement
    • Pattern Recognition Enhancement
    • Visual Acuity Enhancement
    • Auditory Enhancement
    • Brightened colour
    • Enhanced tactile sensation
    • Synaesthesia
    • Increased libido
    • Color enhancement
    • Increased music appreciation
    • Auditory acuity enhancement
    Negative
    • Dehydration
    • Appetite suppression
    Neutral
    • Spontaneous Physical Sensations
    • Drifting
    • Symmetrical Texture Repetition
    • Internal Hallucinations
    • Closed/Open eye visuals
    • Auditory hallucination
    • Auditory distortion
    • Internal hallucination
    • Autonomous entity
    • Gustatory hallucination
    • Perspective hallucination
    • Tactile intensification

    Combinations TripSit

    Cross-Check 25N-NBOMe with another substance

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

    Erowid 1 report 1 cautionary visit
    There Is No Locked in State of Ego Death cautionary exp #105365

    Dossier on the effects of 25n (second trip, 500ug dose): Lots of wavy movements, plenty of color, most of this color is a darker shade, however this could be from my own bad vibes, while the colors blue, green, and pink are also avaliable hues are present as well too, sometimes the wall can fade to a blurry shade of wh...

    wanderer
    25N-NBOMe's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki 📖 TripSit