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    25T-2-NBOMe Stats & Data

    N-bomb 2c-t-2-nbome 25t2-nbome
    NPS DataHub
    MW361.51
    FormulaC20H27NO3S
    CAS1391492-27-5
    IUPAC2-(4-ethylsulfanyl-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine
    SMILESCCSc1cc(OC)c(CCNCc2ccccc2OC)cc1OC
    InChIKeyOZEBFZPAWCXEGK-UHFFFAOYSA-N
    Phenethylamines; 2020/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2021/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2022/1. Von 2-Phenethylamin abgeleitete Verbindungen
    Chemical Class Phenethylamine
    Psychoactive Class Psychedelic
    Half-Life Unknown in humans; NBOMe effects typically last 4\u0000a0\u0000a3\u0000a010 hours with activity persisting beyond perceived offset in some reports.

    Receptor Profile

    Receptor Actions

    Agonists
    5-HT2A receptor agonist (potent)
    5-HT2C receptor agonist
    5-HT2B receptor agonist (cardiotoxic)

    Effect Profile

    Curated
    Psychedelic 6.4

    Strong visuals and body load with moderate auditory effects, mild headspace

    Visual Intensity×3
    10
    Headspace Depth×3
    4
    Auditory Effects×1
    7
    Body Load / Somatic Effects×1
    8

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Unknown in humans; NBOMe effects typically last 4\u0000a0\u0000a3\u0000a010 hours with activity persisting beyond perceived offset in some reports.
    Addiction Potential
    Low physical dependence liability. Psychological craving is uncommon but possible due to stimulant-like euphoria; rapid tolerance limits habitual use.

    Tolerance Decay

    Full tolerance 1d Half tolerance 3d Baseline ~7d

    Cross-tolerance likely with other 5-HT2A psychedelics. Rapid acute tolerance after one session; partial tolerance may persist for about a week. Values are approximate and based on community/series reports rather than controlled studies.

    Cross-Tolerances

    LSD
    70% ●○○
    Psilocybin
    60% ●○○
    2C-x phenethylamines
    50% ●○○
    Other NBOMes
    90% ●●○

    Harm Reduction

    drugs.wiki

    25T-2-NBOMe is a highly potent NBOMe analogue active in the microgram range; overdoses and medical emergencies across the NBOMe family have often resulted from dose misjudgment and mislabeling. Testing and precise measurement are critical. NBOMes have been widely mis-sold as LSD on blotter; LSD fluoresces strongly under 360 nm UV and reacts purple with Ehrlich/Hofmann for lysergamides, while NBOMes have distinct reagent reactions and do not fluoresce like LSD—use multiple reagents (Ehrlich/Hofmann for lysergamides; Marquis/Froehde to screen phenethylamines) and avoid assuming blotters are LSD. Volumetric dosing is strongly advised: dissolve a known weighed amount into a measured volume to create a µg-per-mL solution—drop sizes vary; use measured syringes or pipettes and label clearly; avoid handling loose powder. Sublingual/buccal routes are typical; many NBOMe salts show poor and variable oral GI bioavailability—do not rely on swallowing as a safety test. Insufflation is strongly discouraged due to rapid spikes, severe mucosal irritation, and a disproportionate number of adverse events. Acute risks include vasoconstriction, tachycardia, hypertension, hyperthermia, agitation, and seizures at high dose; emergencies have included rhabdomyolysis. Manage set/setting, avoid hot environments, sip electrolytes, and do not redose the same day. Benzodiazepines are commonly used in clinical settings for severe agitation or seizures from psychedelic crises; avoid antipsychotics unless medically indicated. Combining NBOMes with lithium has been associated with life‑threatening seizures in classic psychedelic reports; avoid this combination entirely. Tramadol and DXM raise serotonin syndrome and seizure risks and should not be combined; bupropion can further lower the seizure threshold. People with cardiovascular disease, epilepsy, or severe mental illness should avoid. Bitter and mouth‑numbing taste on blotter is often reported with NBOMes, but taste alone is unreliable—testing is the only safe approach. Anecdotal reports suggest NBOMes may be associated with HPPD-like persisting visuals; pace use with multi‑week breaks.

    References

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