25T-2-NBOMe Stats & Data
CCSc1cc(OC)c(CCNCc2ccccc2OC)cc1OCOZEBFZPAWCXEGK-UHFFFAOYSA-NReceptor Profile
Receptor Actions
Effect Profile
CuratedStrong visuals and body load with moderate auditory effects, mild headspace
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Cross-tolerance likely with other 5-HT2A psychedelics. Rapid acute tolerance after one session; partial tolerance may persist for about a week. Values are approximate and based on community/series reports rather than controlled studies.
Cross-Tolerances
Harm Reduction
drugs.wiki25T-2-NBOMe is a highly potent NBOMe analogue active in the microgram range; overdoses and medical emergencies across the NBOMe family have often resulted from dose misjudgment and mislabeling. Testing and precise measurement are critical. NBOMes have been widely mis-sold as LSD on blotter; LSD fluoresces strongly under 360 nm UV and reacts purple with Ehrlich/Hofmann for lysergamides, while NBOMes have distinct reagent reactions and do not fluoresce like LSD—use multiple reagents (Ehrlich/Hofmann for lysergamides; Marquis/Froehde to screen phenethylamines) and avoid assuming blotters are LSD. Volumetric dosing is strongly advised: dissolve a known weighed amount into a measured volume to create a µg-per-mL solution—drop sizes vary; use measured syringes or pipettes and label clearly; avoid handling loose powder. Sublingual/buccal routes are typical; many NBOMe salts show poor and variable oral GI bioavailability—do not rely on swallowing as a safety test. Insufflation is strongly discouraged due to rapid spikes, severe mucosal irritation, and a disproportionate number of adverse events. Acute risks include vasoconstriction, tachycardia, hypertension, hyperthermia, agitation, and seizures at high dose; emergencies have included rhabdomyolysis. Manage set/setting, avoid hot environments, sip electrolytes, and do not redose the same day. Benzodiazepines are commonly used in clinical settings for severe agitation or seizures from psychedelic crises; avoid antipsychotics unless medically indicated. Combining NBOMes with lithium has been associated with life‑threatening seizures in classic psychedelic reports; avoid this combination entirely. Tramadol and DXM raise serotonin syndrome and seizure risks and should not be combined; bupropion can further lower the seizure threshold. People with cardiovascular disease, epilepsy, or severe mental illness should avoid. Bitter and mouth‑numbing taste on blotter is often reported with NBOMes, but taste alone is unreliable—testing is the only safe approach. Anecdotal reports suggest NBOMes may be associated with HPPD-like persisting visuals; pace use with multi‑week breaks.
References
Cited References
- Brandt SD et al., 'Analytical and pharmacological profiling of N-benzyl phenethylamine (NBOMe) derivatives', Anal Bioanal Chem 2016
- EMCDDA: Europol Joint Report on NBOMe compounds, 2014
- Iversen L et al., 'Pharmacology of NBOMe hallucinogens at human 5-HT2A receptors', Neuropharmacology 2013
- Johnson RD et al., 'An evaluation of 25B-, 25C-, 25D-, 25H-, 25I- and 25T2-NBOMe via LC-MS-MS', J Anal Toxicol 2014
- PiHKAL Info: 25T2-NBOMe
- TripSit: 25T-2-NBOMe profile
- Wikipedia: 25T2-NBOMe
- Zawilska JB et al., 'NBOMes–Highly Potent and Toxic Alternatives of LSD', Front Neurosci 2020
- Reddit: r/researchchemicals – User experiences with 25T-2-NBOMe (search query)
Drugs.wiki References
- TripSit – NBOMes overview (dosage, duration, oral activity note, risks)
- Erowid – NBOMe series: Spotlight on NBOMes (misrepresentation, taste, vasoconstriction, potency hazards)
- Erowid – 25I‑NBOMe main page (should not be snorted; general warnings)
- Erowid – 25I‑NBOMe Dose/Dosage (microgram ranges; forms incl. HPBCD)
- Erowid – NBOMe effects pages (vasoconstriction, hyperthermia, seizures)
- Erowid – 25C‑NBOMe effects (vasoconstriction, hyperthermia, seizures, serotonin syndrome)
- Erowid – NBOMe Dose page (potency/handling cautions)
- Erowid – Liquid Measurement Technique (volumetric dosing)
- Erowid Crew Blog – On-Site Drug Checking (NBOMe vs LSD reagents; UV fluorescence)
- EUDA drug profile – LSD (fluorescence; Ehrlich colour; analytical notes)
- IsomerDesign / PiHKAL.info – 25T2‑NBOMe identifiers & synonyms
- Erowid – LSD & antidepressants/interactions (lithium: seizures and death reports)
- Erowid – LSD interactions summary (lithium seizure risk)
- DrugBank – Tramadol (seizures; serotonin syndrome risk esp. with serotonergics)
- DrugBank – Dextromethorphan safety overview (MAOI/serotonergic risks)
- DrugBank – Bupropion monograph (lowers seizure threshold)
- Erowid – Psychedelic Crisis FAQ (clinical use of benzodiazepines)
- Bluelight – Taste of LSD thread (anecdotal NBOMe bitter/numbing)