25T-NBOMe
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 3 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: 2c-t-nbome, Nbome-2c-t
Summary
25T-NBOMe is a potent N-2-methoxybenzyl derivative of 2C-T with sub-milligram activity due to high 5-HT2A receptor affinity. It is considerably less studied than 25I-NBOMe and 25C-NBOMe, with minimal human pharmacokinetic data available. Oral bioavailability is poor; sublingual or buccal administration is required.
Dose Information
Dose basis. Ranges are aggregated from user reports on NBOMe series; salt form and exact T-substituent (T2/T4/T7) cause potency variance. Use volumetric dosing; do not eyeball. As with sublingual; hold 15–30 min. Swallowing early may reduce effect unpredictably; do not assume inactivity if swallowed. (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Sublingual | 300-600µg | 600-1200µg | 1200-2000µg | 2000µg+ |
| Buccal | 400-700µg | 700-1400µg | 1400-2200µg | 2200µg+ |
| Insufflated | 200-400µg | 400-700µg | 700-1000µg | 1000µg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Sublingual | 15-45 min | 30-60 min | 2-4 hrs | 2-3 hrs | 4.75-8.75 hrs |
| Buccal | 15-45 min | 30-60 min | 2-4 hrs | 2-3 hrs | 4.75-8.75 hrs |
| Insufflated | 5-15 min | 20-40 min | 2-4 hrs | 2-3 hrs | 4.41-7.92 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Moderate visuals, auditory effects, and body load with mild headspace
Strong anxiety/jitters with moderate euphoria, mild stimulation
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track 25T-NBOMe there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
25T-NBOMe Source: SubstanceSearch (substancesearch.com) Sublingual dose (µg): threshold 200-300 · light 300-600 · common 600-1200 · strong 1200-2000 · heavy 2000+ Buccal dose (µg): threshold 250-400 · light 400-700 · common 700-1400 · strong 1400-2200 · heavy 2200+ Insufflated dose (µg): threshold 100-200 · light 200-400 · common 400-700 · strong 700-1000 · heavy 1000+ Sublingual duration: onset 15-45m · come-up 0.5-1h · peak 2-4h · offset 2-3h · total 4.75-8.75h · after-effects 2-6h Buccal duration: onset 15-45m · come-up 0.5-1h · peak 2-4h · offset 2-3h · total 4.75-8.75h · after-effects 2-6h Insufflated duration: onset 5-15m · come-up 20-40m · peak 2-4h · offset 2-3h · total 4.41-7.92h · after-effects 2-6h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 900 µg (Sublingual).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Rapid, marked tolerance develops after one NBOMe experience; functional tolerance can severely blunt same‑day redoses, encouraging risky escalation. Cross‑tolerance across NBOMes is strong; partial cross‑tolerance likely extends to other classic psychedelics. Data quality is mixed (series‑level reports and user accounts).
Cross-Tolerances
Effects
- Cognitive stimulation
- Stimulation
- Physical euphoria
- Vasoconstriction
- Nausea
- Increased heart rate
- Pupil dilation
- Insomnia
- Restlessness
- Sedation
- Synesthesia
- Euphoria
- Empathy enhancement
- Conceptual thinking
- Anxiety
- Paranoia
- Confusion
- Memory suppression
- Time distortion
- Spiritual or introspective thinking
- Color enhancement
- Tactile enhancement
- Tracers
- Increased music appreciation
- Light sensitivity
- Visual patterning
- Visual drifting
- Closed-eye visuals
- Drifting
- Auditory distortion
Combinations
Cross-Check 25T-NBOMe with another substanceHelpful Links
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