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    Disclaimer
    ☠ NBOMe compounds are active at sub-milligram doses and have been linked to numerous deaths. They are frequently mis-sold as LSD. Always test substances before use.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    25T-NBOMe Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 3 ROAs with full dose ladders
    • duration data present
    • 19 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: 2c-t-nbome, Nbome-2c-t

    Psychedelic Stimulant Research-chemical

    Summary TheDrug.Wiki

    25T-NBOMe is a potent N-2-methoxybenzyl derivative of 2C-T with sub-milligram activity due to high 5-HT2A receptor affinity. It is considerably less studied than 25I-NBOMe and 25C-NBOMe, with minimal human pharmacokinetic data available. Oral bioavailability is poor; sublingual or buccal administration is required.

    Dose Information TheDrug.Wiki

    ROA Light Common Strong Heavy
    Sublingual 300-600µg 600-1200µg 1200-2000µg 2000µg+
    Buccal 400-700µg 700-1400µg 1400-2200µg 2200µg+
    Insufflated 200-400µg 400-700µg 700-1000µg 1000µg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects Total
    Sublingual 15-45 min 2-4 hrs 2-3 hrs 2-6 hrs 6-10 hrs
    Buccal - 2-4 hrs 2-3 hrs 2-6 hrs 6-10 hrs
    Insufflated 5-15 min 2-4 hrs 2-3 hrs 2-6 hrs 6-10 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 5.5
    Strong 6/10

    Moderate visuals, auditory effects, and body load with mild headspace

    Visual Intensity ×3
    7
    color enhancement synesthesia drifting tracers
    Headspace Depth ×3
    4
    conceptual thinking time distortion confusion
    Auditory Effects ×1
    7
    auditory distortion synesthesia
    ⚠ Body Load / Somatic Effects ×1
    6
    vasoconstriction nausea increased heart rate
    Stimulant 3.4
    Light+ 3/10

    Strong anxiety/jitters with moderate euphoria, mild stimulation

    Stimulation / Energy ×3
    5
    stimulation cognitive stimulation
    Euphoria / Mood Lift ×2
    6
    physical euphoria euphoria
    Focus / Productivity ×2
    0
    ⚠ Anxiety / Jitters ×1
    10
    anxiety restlessness paranoia increased heart rate vasoconstriction
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 25T-NBOMe
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use (serotonergic psychedelic)
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1d Half tolerance 7d Baseline ~10d

    Rapid, marked tolerance develops after one NBOMe experience; functional tolerance can severely blunt same‑day redoses, encouraging risky escalation. Cross‑tolerance across NBOMes is strong; partial cross‑tolerance likely extends to other classic psychedelics. Data quality is mixed (series‑level reports and user accounts).

    Cross-Tolerances

    LSD
    60%
    Psilocin/psilocybin
    60%
    Other NBOMe compounds
    90%
    2C‑x series
    40%

    Effects TheDrug.Wiki

    Positive
    • Cognitive stimulation
    • Stimulation
    • Physical euphoria
    Negative
    • Vasoconstriction
    • Nausea
    • Increased heart rate
    • Pupil dilation
    • Insomnia
    • Restlessness
    Neutral
    • Sedation
    Positive
    • Synesthesia
    • Euphoria
    • Empathy enhancement
    • Conceptual thinking
    Negative
    • Anxiety
    • Paranoia
    • Confusion
    • Memory suppression
    Neutral
    • Time distortion
    • Spiritual or introspective thinking
    Positive
    • Color enhancement
    • Tactile enhancement
    • Tracers
    • Increased music appreciation
    Negative
    • Light sensitivity
    Neutral
    • Visual patterning
    • Visual drifting
    • Closed-eye visuals
    • Drifting
    • Auditory distortion

    Combinations TripSit

    Cross-Check 25T-NBOMe with another substance

    25T-NBOMe's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki