Summary
25T-NBOMe is a potent N-2-methoxybenzyl derivative of 2C-T with sub-milligram activity due to high 5-HT2A receptor affinity. It is considerably less studied than 25I-NBOMe and 25C-NBOMe, with minimal human pharmacokinetic data available. Oral bioavailability is poor; sublingual or buccal administration is required. Physiological risks parallel other NBOMes: vasoconstriction, tachycardia, hypertension, hyperthermia, nausea, and anxiety. Severe toxicity including seizures, rhabdomyolysis, and cardiac events have been reported with related NBOMe compounds, particularly at high doses or when combined with stimulants.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Sublingual | 15-45 min | 30-60 min | 2-4 hrs | 2-3 hrs | 2-6 hrs |
| Buccal | 15-45 min | 30-60 min | 2-4 hrs | 2-3 hrs | 2-6 hrs |
| Insufflated | 5-15 min | 20-40 min | 2-4 hrs | 2-3 hrs | 2-6 hrs |
Tolerance
Build-up
develops rapidly after a single use (serotonergic psychedelic)
Reset
7–14 days for baseline
Effects
Positive
- Cognitive stimulation
- Stimulation
- Physical euphoria
Negative
- Vasoconstriction
- Nausea
- Increased heart rate
- Pupil dilation
- Insomnia
- Restlessness
- Sedation
Positive
- Synesthesia
- Euphoria
- Empathy enhancement
- Conceptual thinking
Negative
- Anxiety
- Paranoia
- Confusion
- Memory suppression
- Time distortion
- Spiritual or introspective thinking
Positive
- Color enhancement
- Tactile enhancement
- Tracers
- Increased music appreciation
Negative
- Light sensitivity
- Visual patterning
- Visual drifting
- Closed-eye visuals
- Drifting
- Auditory distortion