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    25T-NBOMe molecular structure

    25T-NBOMe Stats & Data

    2c-t-nbome Nbome-2c-t
    NPS DataHub
    MW347.48
    FormulaC19H25NO3S
    IUPAC2-(2,5-dimethoxy-4-methylsulfanylphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine
    SMILESCOc1ccccc1CNCCc1cc(OC)c(SC)cc1OC
    InChIKeyZWPIZVVOKGWMFW-UHFFFAOYSA-N
    Phenethylamines; 2020/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2021/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2022/1. Von 2-Phenethylamin abgeleitete Verbindungen
    Chemical Class Phenethylamine
    Psychoactive Class Psychedelic / Stimulant
    Half-Life Unknown for 25T‑NBOMe; series analogs (e.g., 25I‑NBOMe) suggest a few hours with prolonged effects due to receptor kinetics.

    Effect Profile

    Curated
    Psychedelic 5.5

    Moderate visuals, auditory effects, and body load with mild headspace

    Visual Intensity×3
    7
    Headspace Depth×3
    4
    Auditory Effects×1
    7
    Body Load / Somatic Effects×1
    6
    Stimulant 3.4

    Strong anxiety/jitters with moderate euphoria, mild stimulation

    Stimulation / Energy×3
    5
    Euphoria / Mood Lift×2
    6
    Focus / Productivity×2
    0
    Anxiety / Jitters×1
    10

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Unknown for 25T‑NBOMe; series analogs (e.g., 25I‑NBOMe) suggest a few hours with prolonged effects due to receptor kinetics.
    Addiction Potential
    Low. Classic serotonergic psychedelics seldom produce compulsive redosing; however sympathetic over-activation and uncomfortable body load may encourage sedative co-use.

    Tolerance Decay

    Full tolerance 1d Half tolerance 3d Baseline ~10d

    Rapid, marked tolerance develops after one NBOMe experience; functional tolerance can severely blunt same‑day redoses, encouraging risky escalation. Cross‑tolerance across NBOMes is strong; partial cross‑tolerance likely extends to other classic psychedelics. Data quality is mixed (series‑level reports and user accounts).

    Cross-Tolerances

    LSD
    60% ●○○
    Psilocin/psilocybin
    60% ●○○
    Other NBOMe compounds
    90% ●●○
    2C‑x series
    40% ●○○

    Harm Reduction

    drugs.wiki

    25T-NBOMe (NBOMe-2C‑T) is a potent, little-studied analogue of 2C‑T derivatives where an N‑(2‑methoxybenzyl) group confers sub‑milligram activity. Oral bioavailability is unreliable across NBOMes; swallowing does not guarantee inactivity—avoid relying on this to “test” blotters. Misrepresented blotter is common; multi‑reagent testing (e.g., Ehrlich to detect indoles for LSD, plus Hofmann/Marquis/Mecke) helps, but very small NBOMe loads can yield weak/no color, and doped tabs may fool Ehrlich—lab drug checking is safest. Insufflation markedly increases risk of severe toxicity (hyperthermia, seizures, rhabdomyolysis) reported for the NBOMe class; avoid nasal, rectal, IM, and IV routes. Because active doses are so small, volumetric dosing in ethanol/water using accurately labeled amber glass is strongly recommended; evaporation of solvent can silently concentrate solutions. Expect rapid tolerance after one experience; redosing the same day adds cardiovascular strain with limited benefit. Individuals with cardiovascular disease, hypertension, Raynaud’s, seizure history, or significant psychiatric instability should avoid NBOMe compounds. Storage stability improves when protected from heat, light, moisture, and oxygen; store blotter/solution cool and dark. Nomenclature note: “25T‑NBOMe” is ambiguous and may refer to several 2C‑T homologues (e.g., 25T2/25T4); potency can vary—treat all as highly potent and experimental.

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