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    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2C-E

    Aliases: Europa, Eternity, Aquarust, 2ce

    Summary PsychonautWiki

    2,5-Dimethoxy-4-ethylphenethylamine (also known as 2C-E, or colloquially as "Aquarust" and "Eternity") is a lesser-known psychedelic substance of the phenethylamine class. It is a member of the 2C-x family of psychedelic phenethylamines, which are closely related to the classical psychedelic mescaline. Like other psychedelics, it is thought to produce its effects by binding to serotonin receptors in the brain, although the precise mechanism is poorly understood.

    Perspectives

    “It seems I have the misfortune of adverse reactions to 2C-E, what has been touted as a spectacular substance by many. The headspace was unique and enjoyable, as was the visual aspect, but unfortunately my explorations seem to be hampered by the feeling of being acutely poisoned.”

    “There was a strange devil-angel pairing. As I was being told of the ecstatic white-light ascent of my partner into the God-space of an out-of-body experience, I was fighting my way out of a brown ooze. She saw the young Jesus at the bottom of a ladder drifting upwards step by step to some taking-off place, and I saw all the funny gargoyles around the base of the ladder surrounded by picnic bunting. For me it was the 4th of July, rather than Easter!”

    “This wasn't bouncy or fun but there was a depth there waiting to be explored. I felt as though I was at the door, peeping inside.”

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 5-10mg 10-15mg 15-30mg 30mg+
    Insufflated 1-4mg 4-7mg 7-14mg 14mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 19-90 min 30-90 min 2-4 hrs 2-3 hrs 4-48 hrs 4-9 hrs
    Insufflated 1-10 min - 1.5-3 hrs 1-2 hrs 2-6 hrs 6-14 hrs

    Effect Profile

    523 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 396 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 8.8
    Intense+ 9/10

    Strong visuals, headspace, auditory effects, and body load

    Visual Intensity ×3
    10
    internal hallucinations colour enhancement autonomous entities drifting tracers synaesthesia +8 more
    Headspace Depth ×3
    10
    conceptual thinking thought connectivity emotion enhancement perspective alterations perspective distortions personal bias suppression +2 more
    Auditory Effects ×1
    10
    auditory distortion auditory enhancement auditory hallucinations auditory hallucination synaesthesia
    Body Load / Somatic Effects ×1
    10
    nausea temperature regulation suppression muscle tension teeth grinding increased heart rate

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1d Half tolerance 7d Baseline ~14d

    Tolerance patterns for 5‑HT2A psychedelics are based on community reports and general HR guidance; high inter‑individual variability. Allow 1–2 weeks between sessions for best effect restoration.

    Cross-Tolerances

    Effects Erowid Bluelight

    Aggregated from 396 Erowid and 127 Bluelight experience reports

    Positive Effects 73

    Visual Distortions 77.6% 79%
    Color Enhancement 57.4% 87%
    Music Enhancement 49.5% 86%
    Stimulation 44.2% 82%
    Euphoria 35.9% 87%
    Empathy 33.2% 79%
    Tactile Enhancement 29.8% 80%
    Closed-Eye Visuals 29.3% 87%
    Introspection 29.3% 84%
    Visual Trails 28.0% 85%
    Auditory Effects 26.5% 82%
    Focus Enhancement 26.2% 75%
    Geometric Imagery 24.0% 86%
    Awe 24.0% 84%
    Open-Eye Visuals 22.2% 87%
    Thought Acceleration 20.0% 81%
    Fractal Imagery 20.0% 88%
    Morphing 20.0% 84%
    Body High 18.8% 86%
    Patterning 18.0% 84%

    Adverse Effects 40

    Anxiety 47.5% 82%
    Nausea 45.3% 85%
    Confusion 33.2% 85%
    Body Load 32.0% 81%
    Muscle Tension 23.1% 79%
    Sedation 22.9% 78%
    Fear 18.0% 83%
    Focus Suppression 12.0% 78%
    Memory Suppression 11.2% 72%
    Vomiting 10.0% 93%
    Headache 8.9% 85%
    Increased Heart Rate 8.1% 70%
    Panic 8.0% 81%
    Shadow Imagery 8.0% 84%
    Motor Impairment 7.6% 82%
    Insomnia 6.0% 82%
    Thought Disorganization 6.0% 75%
    Restlessness 6.0% 78%
    Thought Loops 4.2% 90%
    Delusion 4.0% 82%

    Combinations TripSit

    Trip Reports Effect Index

    PiHKAL / TiHKAL Shulgin

    PiHKAL #24: 2C-E

    “There was a strange devil-angel pairing. As I was being told of the ecstatic white-light ascent of my partner into the God-space of an out-of-body experience, I was fighting my way out of a brown ooze. She saw the young Jesus at the bottom of a ladder drifting upwards step by step to some taking-off place, and I saw all the funny gargoyles around the base of the ladder surrounded by picnic bunting. For me it was the 4th of July, rather than Easter!”

    β€” Alexander Shulgin, PiHKAL (with 16 mg)

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