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    Disclaimer
    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2C-E Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 6 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 18 combo interactions documented
    • PubChem toxicity data
    • classified Research-chemical

    Aliases: Europa, Eternity, Aquarust, 2ce

    Summary PsychonautWiki

    2,5-Dimethoxy-4-ethylphenethylamine (also known as 2C-E, or colloquially as "Aquarust" and "Eternity") is a lesser-known psychedelic substance of the phenethylamine class. It is a member of the 2C-x family of psychedelic phenethylamines, which are closely related to the classical psychedelic mescaline. Like other psychedelics, it is thought to produce its effects by binding to serotonin receptors in the brain, although the precise mechanism is poorly understood.

    Perspectives

    “It seems I have the misfortune of adverse reactions to 2C-E, what has been touted as a spectacular substance by many. The headspace was unique and enjoyable, as was the visual aspect, but unfortunately my explorations seem to be hampered by the feeling of being acutely poisoned.”

    “There was a strange devil-angel pairing. As I was being told of the ecstatic white-light ascent of my partner into the God-space of an out-of-body experience, I was fighting my way out of a brown ooze. She saw the young Jesus at the bottom of a ladder drifting upwards step by step to some taking-off place, and I saw all the funny gargoyles around the base of the ladder surrounded by picnic bunting. For me it was the 4th of July, rather than Easter!”

    “This wasn't bouncy or fun but there was a depth there waiting to be explored. I felt as though I was at the door, peeping inside.”

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 5-10mg 10-15mg 15-30mg 30mg+
    Insufflated 1-4mg 4-7mg 7-14mg 14mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 19-90 min 30-90 min 2-4 hrs 2-3 hrs 4-48 hrs 4-9 hrs
    Insufflated 1-10 min - 1.5-3 hrs 1-2 hrs 2-6 hrs 6-14 hrs

    Effect Profile

    523 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 396 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 8.8
    Intense+ 9/10

    Strong visuals, headspace, auditory effects, and body load

    Visual Intensity ×3
    10
    internal hallucinations colour enhancement autonomous entities drifting tracers synaesthesia +8 more
    Headspace Depth ×3
    10
    conceptual thinking thought connectivity emotion enhancement perspective alterations perspective distortions personal bias suppression +2 more
    Auditory Effects ×1
    10
    auditory distortion auditory enhancement auditory hallucinations auditory hallucination synaesthesia
    Body Load / Somatic Effects ×1
    10
    nausea temperature regulation suppression muscle tension teeth grinding increased heart rate

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1d Half tolerance 7d Baseline ~14d

    Tolerance patterns for 5‑HT2A psychedelics are based on community reports and general HR guidance; high inter‑individual variability. Allow 1–2 weeks between sessions for best effect restoration.

    Cross-Tolerances

    Effects Erowid Bluelight

    Aggregated from 396 Erowid and 127 Bluelight experience reports

    Positive Effects 73

    Visual Distortions 77.6% 79%
    Color Enhancement 57.4% 87%
    Music Enhancement 49.5% 86%
    Stimulation 44.2% 82%
    Euphoria 35.9% 87%
    Empathy 33.2% 79%
    Tactile Enhancement 29.8% 80%
    Closed-Eye Visuals 29.3% 87%
    Introspection 29.3% 84%
    Visual Trails 28.0% 85%
    Auditory Effects 26.5% 82%
    Focus Enhancement 26.2% 75%
    Geometric Imagery 24.0% 86%
    Awe 24.0% 84%
    Open-Eye Visuals 22.2% 87%
    Thought Acceleration 20.0% 81%
    Fractal Imagery 20.0% 88%
    Morphing 20.0% 84%
    Body High 18.8% 86%
    Patterning 18.0% 84%

    Adverse Effects 40

    Anxiety 47.5% 82%
    Nausea 45.3% 85%
    Confusion 33.2% 85%
    Body Load 32.0% 81%
    Muscle Tension 23.1% 79%
    Sedation 22.9% 78%
    Fear 18.0% 83%
    Focus Suppression 12.0% 78%
    Memory Suppression 11.2% 72%
    Vomiting 10.0% 93%
    Headache 8.9% 85%
    Increased Heart Rate 8.1% 70%
    Panic 8.0% 81%
    Shadow Imagery 8.0% 84%
    Motor Impairment 7.6% 82%
    Insomnia 6.0% 82%
    Thought Disorganization 6.0% 75%
    Restlessness 6.0% 78%
    Thought Loops 4.2% 90%
    Delusion 4.0% 82%

    Combinations TripSit

    Cross-Check 2C-E with another substance

    Trip Reports Effect Index

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.

    Erowid 8 reports 3 positive 3 neutral 2 cautionary visit
    One and One are One positive exp #68615

    This was It, the culmination of all my questions and all my fears every state of mind that I knew to be real or simply thought was imaginary was loaded into a cannon and shot directly into my feeble perception of reality, call it god, enlightenment, it may simply be known as I AM I orally ingested one 14mg capsule of 2...

    Maltozombie · 14 mg oral / 3 bowls smoked
    The Beauty and the Beast positive exp #116912

    **Preface:** 2,5-Dimethoxy-4-ethylphenethylamine (2C-E) barely needs an introduction, itΒ’s one of Alexander ShulginΒ’s "magical half-dozen" members and rightfully so. This substance is an unpredictable, dose-sensitive and long-lasting phenethylamine which is quite unlike the other 2C compounds.

    Psychestim
    Glorious Pain, Beauty and Joy positive exp #45329

    Setting: Remote forest location. Set: Good mood, excited, longing for peace. Within an hour the most difficult feelings imaginable came up and I soon realized there was no way to escape them.

    psiphi
    A Psychedelic Voyage Into the Light and Dark neutral exp #96502

    **I realize that making the decision of taking an unknown chemical of an unknown dosage was not the wisest. I was fifteen and made a very uneducated dangerous decision the night I took 2C-E** This is the story of my first earth shattering, psychedelic trip experience.

    Zane F · insufflated / smoked / oral / 0.25 g oral
    God's Instruments of Truth neutral exp #83684

    A brief backround of me: Served 4 years in the Marine Corps, including a tour in Iraq. Developed a drug problem after returning from Iraq, got an Other Than Honorable discharge. Which is actually pretty lucky, considering I was dealing. Faced 60 years for distribution of Ecstasy, LSD, Mushrooms, and Cocaine.

    Jay--The Candyman · oral
    A Lesson in Civil Engineering neutral exp #10583

    After Burning Man 2000, I magically found myself in possession of a little foil packet containing 100 mg of 2C-E. This was probably something I'd never see again, so I had to make the most of these precious crumbs.

    77k
    The Battle between a Good and a Bad Trip cautionary exp #58458

    Intro: This is my first experience with psychoactive substances. Before this night I had only smoked dro once. I have really close friends who helped sit me, and understood the effects of 2c-e and how to take care of me. Overall I couldn't tell you if it was a good or bad trip, but only it was perfect and complete.

    Wolf · 13 mg oral
    2C-Excellent - Ridding My Social Anxiety cautionary exp #100474

    11/24/12 ___________ 2C-E Report ___________ Dose: 36 mg 6 foot male 175 pounds __________________________________________________ __________________________________________________ ***************WARNING**************************** ************************************************** ******** Ingested 36MG at 4:58 A.M I...

    TwoSeeEye
    Bluelight 8 threads 2 positive 4 neutral 2 cautionary visit
    2c E 8mg Rectally 3rd Time Pleasant And Powerful Despite positive

    (2C-E / 8mg - rectally) - 3rd Time - Pleasant and Powerful Despite I considered taking 2C-E again with considerable trepidation, although all of my experiences so far have been positive. I have considered taking it several times in the last year, but I always decided not to.

    scraped 2026-03-14
    2c E 12mg Second Time The Beauty And The Beast neutral

    Preface: 2,5-Dimethoxy-4-ethylphenethylamine (2C-E) barely needs an introduction, it’s one of Alexander Shulgin’s "magical half-dozen" members and rightfully so. This substance is an unpredictable, dose-sensitive and long-lasting phenethylamine which is quite unlike the other 2C compounds.

    scraped 2026-03-14
    2c E First Time Completely Altered neutral

    The other day I had a breathtaking experience with 2C-E that I'd like to share. As with my other recent reports, this will begin with my real-time and unedited notes I took during the experience, and will then summarize in a more coherent fashion, written the next day.

    scraped 2026-03-14
    Contemplative Walk Of Autumn 2c neutral

    Hello bluelight, I wrote a long in details trip report for 2C-E. I want to send it to erowid.org but I would need some reviews before. It was translated from french and I am not sure about some expressions and spelling, etc. If someone could point this out to me, it would really be appreciate.

    scraped 2026-03-14
    2c E 13 8 Mg Brutally Impressive neutral

    Substance: 2C-E HCl (2,5-dimethoxy-4-ethylphenethylamine hydrochloride) Dosage: 13.8 mg (directly on an analytical balance, not calibrated) Purity: homogenous on TLC, sharp melting point Age: mid-20s Weight: ~ 60 kg, a bit underweight Previous experiences: a couple of psychedelics (mostly phenethylamines), various enta...

    scraped 2026-03-14
    2c E Second Time A Trip Back To Childhood cautionary

    2C-E - A trip back to childhood (Warning, very long) June 25th 7:40 P.M. – June 26th 10:00 A.M. – Duration of Experience: 14:20 approx., effects may have extended for the entire day to some degree. Dosage – Dosage was to some extent unknown. NOT RECOMMENDED. Unless you are like me, and crazy.

    scraped 2026-03-14
    2c E 36mg First Trip Changing How I Lived And Ridding My Social Anxiety cautionary

    11/24/12 ___________ 2C-E Report ___________ Dose: 36 mg 6 foot male 175 pounds ___________________________________________________________________________________________________________ ***************WARNING************************************************************************************** Ingested 36MG at 4:58 A...

    scraped 2026-03-14

    Bluelight Reference Guide Bluelight

    The Big & Dandy 2C-E Thread (Second Edition)

    Welcome to the Big & Dandy 2C-E Thread Previous Big & Dandy 2C-E Thread: {First page} {Last Page} Next Big & Dandy 2C-E Thread: {First page} External Information Links: Erowid 2C-E Vault (experience reports) PIHKAL Entry for 2C-E Wikipedia entry Focused Discussion Sub-Threads Please use these threads if you have questi...

    Read full thread on Bluelight β†’

    PiHKAL / TiHKAL Shulgin

    PiHKAL #24: 2C-E

    “There was a strange devil-angel pairing. As I was being told of the ecstatic white-light ascent of my partner into the God-space of an out-of-body experience, I was fighting my way out of a brown ooze. She saw the young Jesus at the bottom of a ladder drifting upwards step by step to some taking-off place, and I saw all the funny gargoyles around the base of the ladder surrounded by picnic bunting. For me it was the 4th of July, rather than Easter!”

    β€” Alexander Shulgin, PiHKAL (with 16 mg)

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