Summary
2C-F is an extraordinarily weak and poorly characterized phenethylamine with virtually no human activity data beyond Alexander Shulgin's personal trials documented in PiHKAL. According to PiHKAL, doses below 100 mg produce no detectable effects, while 250 mg produces only 'slight and uncertain' effects consisting of modest closed-eye visuals accompanied by lethargy. Shulgin explicitly noted that 'at no dose that was tried was there any convincing indication of believable central effects.' Published pharmacological research demonstrates markedly lower 5-HT2A receptor affinity compared to other halogenated 2C analogues, consistent with the compound's exceptional weakness.
Perspectives
“Even at 250 milligrams, the effects were slight and uncertain. There may have been some eyes-closed imagery above normal, but certainly not profound. At several hours there was a pleasant lethargy; sleep was completely normal that night.”
Dose Information
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong visuals with moderate body load, mild headspace
Tolerance
Tolerance Decay
Model extrapolated from general serotonergic psychedelic tolerance patterns and reports for 2C‑B/2C‑T series; no direct PK/PD data for 2C‑F.
Cross-Tolerances
Effects
- Stimulation
- Physical lethargy
- Nausea
- Pupil dilation
- Increased heart rate
- Restlessness
- Muscle tension
- Insomnia
- Mild sedation
- Dilated pupils
- Introspection
- Euphoria
- Empathy
- Insight
- Analysis enhancement
- Confusion
- Memory suppression
- Anxiety
- Subtle mood changes
- Time distortion
- Color enhancement
- Pattern recognition enhancement
- Enhanced tactile sensation
- Tracers
- Color shifting
- Auditory acuity enhancement
- Minimal closed-eye visuals
- Visual distortions
- Drifting
- Perspective hallucination
Combinations
PiHKAL / TiHKAL
“Even at 250 milligrams, the effects were slight and uncertain. There may have been some eyes-closed imagery above normal, but certainly not profound. At several hours there was a pleasant lethargy; sleep was completely normal that night.”