2C-F
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Summary
2C-F is an extraordinarily weak and poorly characterized phenethylamine with virtually no human activity data beyond Alexander Shulgin's personal trials documented in PiHKAL. According to PiHKAL, doses below 100 mg produce no detectable effects, while 250 mg produces only 'slight and uncertain' effects consisting of modest closed-eye visuals accompanied by lethargy. Shulgin explicitly noted that 'at no dose that was tried was there any convincing indication of believable central effects.' Published pharmacological research demonstrates markedly lower 5-HT2A receptor affinity compared to other halogenated 2C analogues, consistent with the compound's exceptional weakness.
Perspectives
“Even at 250 milligrams, the effects were slight and uncertain. There may have been some eyes-closed imagery above normal, but certainly not profound. At several hours there was a pleasant lethargy; sleep was completely normal that night.”
Dose Information
Dose basis. Dose information is derived primarily from Shulgin-era notes and sparse community reports; reliable human data are extremely limited. Reports indicate weak activity requiring multi‑hundred‑milligram amounts; start with an allergy/identity test of 1–5 mg, wait a full 3–4 h, and only proceed if verified by drug checking. Always use a 0.001 g (1 mg) scale or volumetric dosing. Identity confusion with potent look‑alikes (NBOMe/DOx) has occurred historically; treat any untested material as potentially potent. Evidence base: PiHKAL listings and community summaries; see citations. (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 250-350mg | 350-500mg | 500-750mg | 750mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 30-90 min | 2-4 hrs | 2-4 hrs | 6-10 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong visuals with moderate body load, mild headspace
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track 2C-F there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
2C-F Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 100-250 · light 250-350 · common 350-500 · strong 500-750 · heavy 750+ Oral duration: onset 0.5-1.5h · peak 2-4h · offset 2-4h · total 6-10h · after-effects 1-3h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 425 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Model extrapolated from general serotonergic psychedelic tolerance patterns and reports for 2C‑B/2C‑T series; no direct PK/PD data for 2C‑F.
Cross-Tolerances
Effects
- Stimulation
- Physical lethargy
- Nausea
- Pupil dilation
- Increased heart rate
- Restlessness
- Muscle tension
- Insomnia
- Mild sedation
- Dilated pupils
- Introspection
- Euphoria
- Empathy
- Insight
- Analysis enhancement
- Confusion
- Memory suppression
- Anxiety
- Subtle mood changes
- Time distortion
- Color enhancement
- Pattern recognition enhancement
- Enhanced tactile sensation
- Tracers
- Color shifting
- Auditory acuity enhancement
- Minimal closed-eye visuals
- Visual distortions
- Drifting
- Perspective hallucination
Combinations
Cross-Check 2C-F with another substancePiHKAL / TiHKAL
“Even at 250 milligrams, the effects were slight and uncertain. There may have been some eyes-closed imagery above normal, but certainly not profound. At several hours there was a pleasant lethargy; sleep was completely normal that night.”
Helpful Links
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