Summary
Extremely rare research chemical with very limited human data. One known fatality in 2004 resulted from an unknown overdose. Trachsel hypothesizes that 2C-T-21 may metabolize to fluoroacetate, a highly toxic poison, although evidence is speculative. Like 2C-T-7, may exhibit weak reversible MAO-A inhibition. Extreme potency demands accurate milligram-scale weighing and volumetric dosing.
Perspectives
“I noticed something undefined within five minutes which went away. Within 15 minutes I noticed a definite awareness of activity. There was a progressive increase in awareness of something happening over the next two hours with a plateau of perhaps an hour then occurring. The nature of the happening, as usual, was not clear. During the experience I was more talkative than I usually am. I seemed to be interacting with all others. There was no euphoria but, then, there was no body load or nausea, nor was there any nystagmus. I found a little mental confusion at the peak and there was some searching in my memory bank for the right chips at times. I lost the entire line of one of my conversations at one point during the plateau and had to ask what I was talking about. I tested my visual field on a painting and with sufficient concentration I could get the center part to wiggle a little. I didn’t try to observe anything with my eyes closed. I feel that there was something physical about the eyes. In the evening, after-images were quite intense, and the next day my eyes seemed tired or bothered. What can I say? The material was pleasant and I certainly got the feeling of being high but not getting too much out of it. There were no insights or “ah-hahs.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-10mg | 10-12mg | 12-15mg | 15mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 15-40 min | 30-60 min | 2-5 hrs | 2-4 hrs | 2-12 hrs | 360-0 min |
| Insufflated | 5-15 min | 15-30 min | 2-5 hrs | 2-4 hrs | 2-12 hrs | 360-0 min |
Tolerance
Effects
- Stimulation
- Mental/physical stimulation
- Temperature regulation suppression
- Increased heart rate
- Increased blood pressure
- Pupil dilation
- Nausea
- Teeth grinding
- Muscle tension
- Restlessness
- Sweating/chills
- Insomnia
- Headache
- Muscle cramp
- Stomach cramp
- Watery eyes
- Increased perspiration
- Abnormal heartbeat
- Stomach bloating
- Diarrhea
- Muscle twitching
- Decreased appetite
- Difficulty urinating
- Frequent urination
- Spontaneous bodily sensations
- Excessive yawning
- Muscle contractions
- Increased bodily temperature
- Emotion enhancement
- Empathy
- Euphoria
- Analysis enhancement
- Conceptual thinking
- Wakefulness
- Insight
- Novelty enhancement
- Unity and interconnectedness
- Immersion intensification
- Anxiety
- Confusion
- Dizziness
- Delusion
- Memory suppression
- Thought acceleration
- Time distortion
- Change in perception
- Ego softening
- Thought loop
- Personal bias suppression
- Emotion intensification
- Bodily control enhancement
- Tactile enhancement
- Visual enhancement
- Tracers
- Increased music appreciation
- Brightened colour
- Enhanced tactile sensation
- Pattern recognition enhancement
- Color enhancement
- Visual acuity enhancement
- Color shifting
- Auditory acuity enhancement
- Appetite suppression
- Dehydration
- Spontaneous physical sensations
- Visual drifting
- Symmetrical texture repetition
- After images
- Closed/Open eye visuals
- Auditory distortion
- Changes in felt bodily form
- Internal hallucination
- Autonomous entity
- Drifting
- Perspective hallucination
- Tactile intensification
Combinations
PiHKAL / TiHKAL
“I noticed something undefined within five minutes which went away. Within 15 minutes I noticed a definite awareness of activity. There was a progressive increase in awareness of something happening over the next two hours with a plateau of perhaps an hour then occurring. The nature of the happening, as usual, was not clear. During the experience I was more talkative than I usually am. I seemed to be interacting with all others. There was no euphoria but, then, there was no body load or nausea, nor was there any nystagmus. I found a little mental confusion at the peak and there was some searching in my memory bank for the right chips at times. I lost the entire line of one of my conversations at one point during the plateau and had to ask what I was talking about. I tested my visual field on a painting and with sufficient concentration I could get the center part to wiggle a little. I didn’t try to observe anything with my eyes closed. I feel that there was something physical about the eyes. In the evening, after-images were quite intense, and the next day my eyes seemed tired or bothered. What can I say? The material was pleasant and I certainly got the feeling of being high but not getting too much out of it. There were no insights or “ah-hahs.”