Summary
3-CMC is a meta-chlorinated cathinone with significant neurotoxic and cardiotoxic concerns. Animal studies demonstrate neurotoxicity in mice, and its structural similarity to known neurotoxins like 4-CMA raises serious safety concerns. The compound is chemically unstable and degrades to potentially more toxic metabolites. At least 10 deaths with confirmed 3-CMC exposure have been reported in Europe between 2019-2021. Short half-life encourages compulsive redosing, increasing risks of hyperthermia, hypertension, agitation, and severe comedown symptoms.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 30-60mg | 60-100mg | 100-180mg | 180mg+ |
| Insufflated | 20-40mg | 40-80mg | 80-100mg | 100mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 30-90 min | 30-60 min | 60-90 min | 1-2 hrs | 4-12 hrs |
| Insufflated | 10-30 min | 15-30 min | 30-60 min | 30-60 min | 3-6 hrs |
Tolerance
Build-up
develops rapidly, often within a single session; compulsive redosing common
Reset
a few days for acute tolerance
Effects
Positive
- Stimulation
- Increased energy/alertness
Negative
- Teeth grinding
- Increased perspiration
- Muscle spasms
- Weight loss
- Sweating
- Bruxism
- Decreased need for sleep
- Decreased appetite
- Disturbed sleep patterns
- Itchiness
Positive
- Euphoria
- Sociability enhancement
- Empathy enhancement
- Wakefulness
- Increased sociability
- Mood lift
Negative
- Anxiety
- Compulsive redosing
- Aggressiveness
- Excessive talking
- Moodiness
Positive
- Increased libido
- Tactile enhancement
- Increased music appreciation
- Tracers
Negative
- Appetite suppression
- Light sensitivity
- Dehydration
- Disinhibition
- Increased sexuality
- Visual and auditory hallucinations