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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    3-CMC

    Aliases: Clophedrone, 3-chloromethcathinone, 3cmc

    Stimulant Research-chemical

    Summary TheDrug.Wiki TripSit

    3-CMC is a meta-chlorinated cathinone with significant neurotoxic and cardiotoxic concerns. Animal studies demonstrate neurotoxicity in mice, and its structural similarity to known neurotoxins like 4-CMA raises serious safety concerns. The compound is chemically unstable and degrades to potentially more toxic metabolites.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 30-60mg 60-100mg 100-180mg 180mg+
    Insufflated 20-40mg 40-80mg 80-100mg 100mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects
    Oral 30-90 min 30-60 min 60-90 min 1-2 hrs 4-12 hrs
    Insufflated 10-30 min 15-30 min 30-60 min 30-60 min 3-6 hrs

    Effect Profile

    2 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Empathogen 6.0
    Strong 6/10

    Moderate empathy and stimulation with mild euphoria and sensory enhancement

    Empathy / Social Openness ×3
    7
    empathy enhancement sociability enhancement increased sociability
    Euphoria / Mood Elevation ×2
    5
    euphoria mood lift
    Stimulation ×1
    6
    stimulation wakefulness teeth grinding
    Sensory Enhancement ×1
    5
    tactile enhancement increased libido
    Stimulant 3.2
    Light+ 3/10

    Strong anxiety/jitters with mild stimulation and euphoria

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    5
    euphoria mood lift
    Focus / Productivity ×2
    0
    ⚠ Anxiety / Jitters ×1
    9
    anxiety teeth grinding bruxism sweating
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 3-CMC
    View methodology →

    Tolerance

    Build-up develops rapidly, often within a single session; compulsive redosing common
    Reset a few days for acute tolerance

    Tolerance Decay

    Full tolerance 2d Half tolerance 10d Baseline ~35d

    Patterns inferred from stimulant/cathinone use reports: notable acute tachyphylaxis within a session, residual tolerance persisting days to weeks; robust evidence is lacking.

    Cross-Tolerances

    other cathinones (e.g., 3‑MMC, 4‑CMC)
    30%
    amphetamine‑type stimulants
    20%

    Effects TheDrug.Wiki TripSit

    Positive
    • Stimulation
    • Increased energy/alertness
    Negative
    • Teeth grinding
    • Increased perspiration
    • Muscle spasms
    • Weight loss
    • Sweating
    • Bruxism
    Neutral
    • Decreased need for sleep
    • Decreased appetite
    • Disturbed sleep patterns
    • Itchiness
    Positive
    • Euphoria
    • Sociability enhancement
    • Empathy enhancement
    • Wakefulness
    • Increased sociability
    • Mood lift
    Negative
    • Anxiety
    • Compulsive redosing
    • Aggressiveness
    Neutral
    • Excessive talking
    • Moodiness
    Positive
    • Increased libido
    • Tactile enhancement
    • Increased music appreciation
    • Tracers
    Negative
    • Appetite suppression
    • Light sensitivity
    • Dehydration
    • Disinhibition
    Neutral
    • Increased sexuality
    • Visual and auditory hallucinations

    Combinations TripSit

    3-CMC's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki