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    3-FMC molecular structure

    3-FMC Stats & Data

    3-fluoromethcathinone
    NPS DataHub
    MW181.21
    FormulaC10H12FNO
    CAS1049677-77-1
    SMILESCNC(C)C(=O)c1cccc(F)c1
    InChIKeyPQIBROLLUQSNQI-UHFFFAOYSA-N
    Phenethylamines; Cathinones; 2020/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2021/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2022/1. Von 2-Phenethylamin abgeleitete Verbindungen
    Chemical Class Cathinone
    Psychoactive Class Stimulant
    Half-Life Unknown in humans; user timelines suggest acute effects 2–4 h with residual stimulation beyond this. Avoid precise scheduling assumptions without lab-confirmed PK.

    Receptor Profile

    Receptor Actions

    Inhibitors
    Dopamine-norepinephrine reuptake inhibitor (NDRI)
    Other
    Dopamine-norepinephrine releasing agent (DNRA)

    History & Culture

    3-Fluoromethcathinone emerged as part of the wave of novel cathinone designer drugs sold online, appearing alongside numerous other synthetic cathinones marketed as alternatives to controlled stimulants. As a structural isomer of flephedrone (4-fluoromethcathinone), it belongs to a family of fluorinated methcathinone derivatives that were developed and distributed primarily through online research chemical vendors. The compound is structurally related to mephedrone, sharing the core cathinone scaffold while differing in the position of the fluorine substituent on the phenyl ring. Limited documentation exists regarding the specific origins, initial synthesis, or timeline of 3-FMC's appearance on the designer drug market. Like many novel psychoactive substances of the cathinone class, it appears to have been introduced without formal pharmacological characterization, with most available information derived from user reports and subsequent analytical identification by forensic laboratories.

    Effect Profile

    Curated
    Empathogen 4.9

    Moderate stimulation with mild euphoria, sensory enhancement, and empathy

    Empathy / Social Openness×3
    4
    Euphoria / Mood Elevation×2
    5
    Stimulation×1
    7
    Sensory Enhancement×1
    5
    Stimulant 4.9

    Strong anxiety/jitters with moderate euphoria, mild stimulation and focus

    Stimulation / Energy×3
    5
    Euphoria / Mood Lift×2
    7
    Focus / Productivity×2
    5
    Anxiety / Jitters×1
    10

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Unknown in humans; user timelines suggest acute effects 2–4 h with residual stimulation beyond this. Avoid precise scheduling assumptions without lab-confirmed PK.
    Addiction Potential
    Moderate to high; short duration with clear on/off encourages compulsive redosing typical of cathinone stimulants. Binge patterns commonly reported anecdotally.

    Tolerance Decay

    Full tolerance 1d Half tolerance 7d Baseline ~30d

    Cathinone stimulants often exhibit rapid within‑session tolerance with partial recovery over 1–2 weeks and nearer‑baseline by 4–6 weeks; values are heuristic from community reports and analogous agents, not formal PK/PD data.

    Cross-Tolerances

    Other substituted cathinones (e.g., 3‑MMC/4‑MMC)
    60% ●○○
    Amphetamine/methamphetamine
    40% ●○○
    Methylphenidate
    20% ●○○

    Legal Status

    Country Status Notes
    Czech Republic Banned Prohibited substance under national drug legislation. Possession, production, and distribution are illegal.
    Germany Anlage II BtMG Listed in Anlage II of the Betäubungsmittelgesetz (Narcotics Act). Unlike Anlage I substances, Anlage II compounds are marketable but require prescription and are subject to strict regulatory controls.
    United Kingdom Class B Controlled under the cathinone blanket ban implemented through the Misuse of Drugs Act 1971. All substituted cathinones were classified as Class B substances in 2010.
    United States Schedule I Classified as a Schedule I controlled substance under federal law. Considered to have high abuse potential with no accepted medical use. Possession, distribution, and manufacturing are prohibited.

    Harm Reduction

    drugs.wiki

    • Identity/Isomer confusion: 3-FMC (meta‑fluoro) is distinct from 4‑FMC (flephedrone); vendors and user reports have historically mixed these—obtain analytical confirmation where possible. • Severe market mislabeling across cathinones is currently common; drug-checking services have repeatedly found 3‑MMC samples to contain more potent stimulants like NEP or α‑PVP—start with an allergy test dose and get products checked. • Very caustic to nasal mucosa: user reports consistently describe intense burn and lingering rhinitis; rotate nostrils, finely crush, consider oral ROA to reduce damage. • Cardiovascular strain (tachycardia, hypertension) and peripheral vasoconstriction can occur; avoid overheating, heavy exertion, and hot environments; take cooling breaks and monitor for chest pain or cold, numb extremities. • Hydration: sip small amounts of water with electrolytes; avoid both dehydration and overhydration. • Sleep deprivation and redosing escalate risk for panic, paranoia, compulsive behavior; pre‑plan a hard stop time and secure sleep support (non‑alcoholic). • Avoid stacking with other serotonergic agents (especially MAOIs and tramadol); if on prescription antidepressants, expect blunted effects and increased unpredictability. • Use an accurate milligram scale; do not eyeball powders. • Rectal/IV routes can magnify potency/risks; avoid injecting RC stimulants due to unknown impurities and high harm profile. • Space sessions widely (minimum several weeks) to allow mood/monoamines to recover and to reduce reinforcement.

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