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    3-MeO-PCMo molecular structure

    3-MeO-PCMo Stats & Data

    Pcmo
    NPS DataHub
    MW275.39
    FormulaC17H25NO2
    CAS138873-80-0
    IUPAC4-[1-(3-methoxyphenyl)cyclohexyl]morpholine
    SMILESCOc1cccc(c1)C1(CCCCC1)N1CCOCC1
    InChIKeyBOGOEDFWPOXWQE-UHFFFAOYSA-N
    Arylcyclohexylamines; 2021/6. Von Arylcyclohexylamin abgeleitete Verbindungen; 2022/6. Von Arylcyclohexylamin abgeleitete Verbindungen
    Psychoactive Class Dissociative
    Half-Life Unknown in humans as of 2025; user reports suggest short-acting primary effects (3–5 h) with after-effects into the same or next day depending on dose.

    Receptor Profile

    Receptor Actions

    Agonists
    Sigma-1 receptor agonist
    Antagonists
    NMDA receptor antagonist (noncompetitive)

    Receptor Binding

    NMDA antagonist

    History & Culture

    3-MeO-PCMo is a novel dissociative substance that emerged on the gray market as a designer drug in the mid-2010s. It became available primarily through online research chemical vendors, where it was marketed alongside other novel arylcyclohexylamines. As a relatively obscure compound, it has accumulated only a limited history of human use compared to more established dissociatives. While 3-MeO-PCMo itself lacks extensive documentation, morpholine-substituted analogues of phencyclidine have appeared in earlier pharmacological research. However, comprehensive studies on this specific compound remain scarce, and most available information derives from anecdotal reports within online psychonaut communities rather than formal scientific investigation.

    Subjective Effect Notes

    cognitive: The general head space of 3-MeO-PCMo is often described as simplistic and shallow in comparison to that of MXE and ketamine.

    Effect Profile

    Curated + 2 Reports
    Dissociative 5.4

    Strong dissociative depth, mania, and motor impairment with mild insight

    Dissociative Depth×3
    10
    Mania / Compulsion×1
    10
    Insight / Novel Thought×2
    4
    Motor / Sensory Impairment×1
    10

    Duration Timeline

    Bluelight
    Onset Comeup Peak Offset After Effects
    Oral
    30 minutes - 1.5 hours
    2-3 hours
    1-2 hours
    2-8 hours
    Total: 5-6 hours
    Insufflated
    4-15 minutes
    1-2 hours
    1-2 hours
    2-8 hours
    Total: 3-5 hours

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Unknown in humans as of 2025; user reports suggest short-acting primary effects (3–5 h) with after-effects into the same or next day depending on dose.
    Addiction Potential
    Unknown in formal studies for humans; dissociatives can promote psychological craving and redosing in some users. Ambulatory delirium and mania-like states are reported at higher doses with related arylcyclohexylamines; frequent redosing increases risk of harm. Treat as having at least moderate psychological addiction potential.

    Tolerance Decay

    Full tolerance 3d Half tolerance 7d Baseline ~28d

    Pattern inferred from dissociative-class use; high uncertainty due to sparse PCMo-specific data. Many user reports suggest meaningful cross-tolerance within arylcyclohexylamines; long spacing between sessions (2–6 weeks) helps restore sensitivity.

    Cross-Tolerances

    Ketamine
    50% ●○○
    3-MeO-PCP
    60% ●○○
    Other arylcyclohexylamines (e.g., MXE, 3-MeO-PCE)
    40% ●○○

    Experience Report Analysis

    Erowid
    2 Reports
    2015–2015 Date Range
    2 With Age Data

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Legal Status

    Country Status Notes
    Germany Controlled (NpSG) Controlled under the Neue-psychoaktive-Stoffe-Gesetz (New Psychoactive Substances Act) as of July 18, 2019. Production and import with intent to distribute, administration to others, and trading are punishable offenses. Possession is technically illegal but not subject to criminal penalties.
    Switzerland Controlled (Verzeichnis E) Specifically named as a controlled substance under Verzeichnis E of Swiss narcotics legislation. Production, distribution, and possession without authorization are prohibited.
    United Kingdom Controlled (Psychoactive Substances Act) Controlled under the Psychoactive Substances Act 2016, which took effect on May 26, 2016. Production, supply, and importation are illegal. Notably, 3-MeO-PCMo falls outside the generic arylcyclohexylamine definition in the Misuse of Drugs Act 1971 because its morpholine substituent is not covered by that legislation. Simple possession outside of custodial institutions is not criminalized under the PSA.

    Harm Reduction

    drugs.wiki

    • Potency is far lower than 3‑MeO‑PCP, with many reports placing active oral and insufflated ranges in the 100–200+ mg area; always confirm identity with reagent or lab testing and start with a micro‑allergy test (1–3 mg). • Onset can lag 30–60 minutes orally; avoid redosing for at least 2 hours to prevent accidental stacking and unexpectedly strong intoxication. • Maintain a safe environment: dissociatives can impair balance and judgment while leaving users ambulatory; falls, wandering, and risk-taking behavior are documented with related analogues. • Nasal use: crystals are reported as poorly water‑soluble; insufflation may be inefficient and irritating—consider oral administration if choosing to proceed. • Hydration and bladder care matter: chronic/high‑frequency use of dissociatives has been linked to urinary tract symptoms (best practice is to limit frequency and maintain hydration). • Strong CNS depressant combinations (alcohol, GHB/GBL, opioids) markedly increase risks of unconsciousness, aspiration, and respiratory compromise—avoid these mixes. • If someone becomes severely confused, agitated, or unresponsive, seek medical care; supportive management, temperature control, and benzodiazepines for agitation are commonly used in clinical settings. • Tolerance builds quickly across the dissociative class; spacing sessions by several weeks reduces risk of escalation and adverse effects. • Due to extremely limited formal data and frequent mislabeling in the unregulated market, treat all material with caution; use drug checking services where available and avoid driving or hazardous activities for at least 12–24 hours after significant dosing.

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