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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    3-MeO-PCMo

    Aliases: Pcmo

    Dissociative Research-chemical

    Summary TheDrug.Wiki TripSit PsychonautWiki

    3-MeO-PCMo (4-[1-(3-methoxyphenyl)cyclohexyl]morpholine) is a new morpholine analogue of 3-MeO-PCP. It is a dissociative NMDA receptor antagonist, sigma receptor agonist and anesthetic drug of the arylcyclohexylamine chemical class with a potency of less than 1/10th of that of 3-MeO-PCP. This compound induces a state referred to as "dissociative anesthesia" when ingested and is therefore used as a recreational drug.

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 100-200mg 200-300mg 300-400mg 400mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Peak Offset After Effects Total
    Oral 30-90 min 2-3 hrs 1-2 hrs 2-8 hrs 5-6 hrs
    Insufflated 4-15 min 1-2 hrs 1-2 hrs 2-8 hrs 3-5 hrs

    Effect Profile

    2 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Dissociative 5.4
    Moderate+ 5/10

    Strong dissociative depth, mania, and motor impairment with mild insight

    Dissociative Depth ×3
    10
    depersonalization derealization consciousness disconnection physical disconnection cognitive disconnection visual disconnection +5 more
    ⚠ Mania / Compulsion ×1
    10
    mania compulsive redosing disinhibition increased energy stimulation
    Insight / Novel Thought ×2
    4
    conceptual thinking creativity enhancement
    ⚠ Motor / Sensory Impairment ×1
    10
    motor control loss physical disconnection tactile suppression spatial disorientation visual disconnection double vision
    Based on reports from:
    Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki 3-MeO-PCMo The Drug Users Bible 3-MeO-PCMo
    View methodology →

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2–4 weeks for noticeable reduction

    Tolerance Decay

    Full tolerance 3d Half tolerance 7d Baseline ~28d

    Pattern inferred from dissociative-class use; high uncertainty due to sparse PCMo-specific data. Many user reports suggest meaningful cross-tolerance within arylcyclohexylamines; long spacing between sessions (2–6 weeks) helps restore sensitivity.

    Cross-Tolerances

    Ketamine
    50%
    3-MeO-PCP
    60%
    Other arylcyclohexylamines (e.g., MXE, 3-MeO-PCE)
    40%

    Effects TheDrug.Wiki PsychonautWiki

    Positive
    • Physical euphoria
    • Analgesia
    • Creativity enhancement
    • Increased energy
    • Stimulation
    Negative
    • Nausea
    • Headache
    • Insomnia
    Neutral
    • Physical disconnection
    • Spontaneous bodily sensations
    Positive
    • Cognitive euphoria
    • Conceptual thinking
    • Anxiety suppression
    • Dream potentiation
    • Immersion intensification
    • Increased introspection
    Negative
    • Motor control loss
    • Depersonalization
    • Derealization
    • Thought deceleration
    • Compulsive redosing
    • Mania
    • Cognitive disconnection
    • Memory suppression
    • Amnesia
    Neutral
    • Time distortion
    • Consciousness disconnection
    • Perspective distortion
    • Physical autonomy
    • Existential self-realization
    Positive
    • Perception of bodily lightness
    • Tactile enhancement
    • Increased music appreciation
    Negative
    • Tactile suppression
    • Spatial disorientation
    • Double vision
    • Pattern recognition suppression
    • Visual acuity suppression
    • Disinhibition
    • Auditory acuity suppression
    Neutral
    • Spontaneous physical sensations
    • Visual disconnection
    • Auditory hallucination
    • Auditory distortion
    • Visual processing deceleration

    Combinations TripSit

    3-MeO-PCMo's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki 📖 TripSit 📖 Bluelight 📖 The Drug Users Bible