3-MeO-PCPr
Aliases: 3-methoxyphencyclidine propylamino
Categories
Summary
3-MeO-PCPr is a potent N-propyl analogue of 3-MeO-PCP with high NMDA receptor affinity (Ki = 25 nM). It is notably more stimulating and euphoric than many related dissociatives due to pronounced dopamine reuptake inhibition, which significantly increases compulsive redosing risk. Individual sensitivity varies widely. The substance has a long duration with residual effects persisting up to 12 hours or more. Overdose can cause severe dissociation, mania, psychosis, and cardiovascular stress.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-8mg | 8-15mg | 15-20mg | 20mg+ |
| Insufflated | 1-3mg | 3-8mg | 8-15mg | 15mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 15-30 min | 30-60 min | 2-4 hrs | 2-4 hrs | 1-12 hrs |
| Insufflated | 5-10 min | 15-30 min | 1-3 hrs | 2-3 hrs | 1-8 hrs |
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2–4 weeks for noticeable reduction
Cross-tolerance
Effects
Positive
- Stimulation
- Physical euphoria
- Analgesia
- Pain relief
Negative
- Increased heart rate
- Numbness
- Loss of balance
- Nausea
- Physical disconnection
- Sedation
Positive
- Cognitive euphoria
Negative
- Motor control loss
- Compulsive redosing
- Mania
- Delusion
- Confusion
- Amnesia
- Depersonalization
- Dissociation
- Time distortion
Positive
- Tactile enhancement
- Increased music appreciation
Negative
- Disinhibition
- Tactile suppression
- Light sensitivity
- Spatial disorientation
- Double vision
- Pattern recognition suppression
- Visual disconnection
- Auditory distortion