3-MeO-PCPr
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Tentative
- classified Research-chemical
- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Tentative
- classified Research-chemical
Aliases: 3-methoxyphencyclidine propylamino
Summary
3-MeO-PCPr is a potent N-propyl analogue of 3-MeO-PCP with high NMDA receptor affinity (Ki = 25 nM). It is notably more stimulating and euphoric than many related dissociatives due to pronounced dopamine reuptake inhibition, which significantly increases compulsive redosing risk. Individual sensitivity varies widely.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-8mg | 8-15mg | 15-20mg | 20mg+ |
| Insufflated | 1-3mg | 3-8mg | 8-15mg | 15mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 15-30 min | 30-60 min | 2-4 hrs | 2-4 hrs | 4.75-9.5 hrs |
| Insufflated | 5-10 min | 15-30 min | 1-3 hrs | 2-3 hrs | 3.33-6.67 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong mania, motor impairment, and dissociative depth
Moderate euphoria with low stimulation and anxiety/jitters
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track 3-MeO-PCPr there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
3-MeO-PCPr Source: SubstanceSearch (substancesearch.com) Oral dose (mg): light 5-8 · common 8-15 · strong 15-20 · heavy 20+ Insufflated dose (mg): light 1-3 · common 3-8 · strong 8-15 · heavy 15+ Oral duration: onset 15-30m · come-up 0.5-1h · peak 2-4h · offset 2-4h · total 4.75-9.5h · after-effects 1-12h Insufflated duration: onset 5-10m · come-up 15-30m · peak 1-3h · offset 2-3h · total 3.33-6.67h · after-effects 1-8h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 11.5 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Estimates reflect community experience with arylcyclohexylamines (rapid tolerance build with partial reversal over 1–4 weeks) and should be treated as approximate. Cross‑tolerance across NMDA antagonists is expected but extent varies.
Cross-Tolerances
Effects
- Stimulation
- Physical euphoria
- Analgesia
- Pain relief
- Increased heart rate
- Numbness
- Loss of balance
- Nausea
- Physical disconnection
- Sedation
- Cognitive euphoria
- Motor control loss
- Compulsive redosing
- Mania
- Delusion
- Confusion
- Amnesia
- Depersonalization
- Dissociation
- Time distortion
- Tactile enhancement
- Increased music appreciation
- Disinhibition
- Tactile suppression
- Light sensitivity
- Spatial disorientation
- Double vision
- Pattern recognition suppression
- Visual disconnection
- Auditory distortion
Combinations
Cross-Check 3-MeO-PCPr with another substanceHelpful Links
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