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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    3-MeO-PCPr

    Aliases: 3-methoxyphencyclidine propylamino

    Dissociative Stimulant Research-chemical

    Summary TheDrug.Wiki TripSit

    3-MeO-PCPr is a potent N-propyl analogue of 3-MeO-PCP with high NMDA receptor affinity (Ki = 25 nM). It is notably more stimulating and euphoric than many related dissociatives due to pronounced dopamine reuptake inhibition, which significantly increases compulsive redosing risk. Individual sensitivity varies widely.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 5-8mg 8-15mg 15-20mg 20mg+
    Insufflated 1-3mg 3-8mg 8-15mg 15mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects
    Oral 15-30 min 30-60 min 2-4 hrs 2-4 hrs 1-12 hrs
    Insufflated 5-10 min 15-30 min 1-3 hrs 2-3 hrs 1-8 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Dissociative 3.4
    Light+ 3/10

    Strong mania, motor impairment, and dissociative depth

    Dissociative Depth ×3
    8
    depersonalization physical disconnection visual disconnection spatial disorientation amnesia
    ⚠ Mania / Compulsion ×1
    10
    mania compulsive redosing disinhibition stimulation
    Insight / Novel Thought ×2
    0
    ⚠ Motor / Sensory Impairment ×1
    10
    motor control loss physical disconnection tactile suppression numbness spatial disorientation visual disconnection +1 more
    Stimulant 3.6
    Moderate 4/10

    Moderate euphoria with low stimulation and anxiety/jitters

    Stimulation / Energy ×3
    3
    stimulation
    Euphoria / Mood Lift ×2
    6
    physical euphoria cognitive euphoria
    Focus / Productivity ×2
    0
    ⚠ Anxiety / Jitters ×1
    2
    increased heart rate
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 3-MeO-PCPr
    View methodology →

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2–4 weeks for noticeable reduction

    Tolerance Decay

    Full tolerance 3d Half tolerance 7d Baseline ~14d

    Estimates reflect community experience with arylcyclohexylamines (rapid tolerance build with partial reversal over 1–4 weeks) and should be treated as approximate. Cross‑tolerance across NMDA antagonists is expected but extent varies.

    Cross-Tolerances

    3-MeO-PCP
    70%
    MXE / DMXE
    60%
    Ketamine / DCK
    50%

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    • Physical euphoria
    • Analgesia
    • Pain relief
    Negative
    • Increased heart rate
    • Numbness
    • Loss of balance
    • Nausea
    Neutral
    • Physical disconnection
    • Sedation
    Positive
    • Cognitive euphoria
    Negative
    • Motor control loss
    • Compulsive redosing
    • Mania
    • Delusion
    • Confusion
    • Amnesia
    • Depersonalization
    Neutral
    • Dissociation
    • Time distortion
    Positive
    • Tactile enhancement
    • Increased music appreciation
    Negative
    • Disinhibition
    • Tactile suppression
    • Light sensitivity
    • Spatial disorientation
    • Double vision
    • Pattern recognition suppression
    Neutral
    • Visual disconnection
    • Auditory distortion

    Combinations TripSit

    3-MeO-PCPr's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki