Summary
3-MeO-PCP is a dissociative anesthetic with effects that are compared to PCP and ketamine. It is an NMDA receptor antagonist. It has been available in online research chemical markets since 2010, with wide distribution beginning in 2011. Because it is less physically sedating than ketamine, strong doses of it can cause ambulatory delirious states during which users may not realize they are unable to differentiate reality from fantasy. At least one confirmed death has been associated with its use.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral BA ~70-90% | 4-8mg | 8-15mg | 15-25mg | 25mg+ |
| Insufflated BA ~80-90% | 2-5mg | 5-8mg | 8-12mg | 12-15mg+ |
| Smoked | 5-10mg | 10-20mg | 20-25mg | 25mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 30-90 min | 0.75-2.0 hrs | 2.0-3.0 hrs | 1.0-2.0 hrs | 4.0-48.0 hrs | 3.0-5.0 hrs |
| Insufflated | 4-30 min | 45-90 min | 1.5-2.0 hrs | 45-60 min | 4.0-48.0 hrs | 2.0-4.0 hrs |
| Sublingual | - | - | - | - | 2.0-48.0 hrs | - |
| Smoked | - | - | - | - | 2.0-48.0 hrs | - |
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2–4 weeks for noticeable reduction
Cross-tolerance
Effects
Positive
- Stimulation
- Physical euphoria
- Analgesia
- Creativity enhancement
- Spontaneous tactile sensations
- Nausea suppression
- Pain relief
Negative
- Increased heart rate
- Nausea
- Respiratory depression
- Increased blood pressure
- Increased perspiration
- Seizure
- Abnormal heartbeat
- Tactile disconnection
- Physical disconnection
- Difficulty urinating
- Restless legs
- Spontaneous bodily sensations
Positive
- Cognitive euphoria
- Anxiety suppression
- Analysis enhancement
- Conceptual thinking
- Immersion enhancement
- Mindfulness
- Dream potentiation
- Addiction suppression
- Immersion intensification
Negative
- Motor control loss
- Mania
- Delusions
- Psychosis
- Compulsive redosing
- Depersonalization
- Derealization
- Amnesia
- Dizziness
- Information processing suppression
- Memory suppression
- Cognitive disconnection
- Delusion
- Thought deceleration
- Dissociation
- Consciousness disconnection
- Feelings of impending doom
- Perspective alterations
- Perspective distortions
- Physical autonomy
- Perspective distortion
- Time distortion
- Existential self-realization
Positive
- Tactile enhancement
- Increased libido
- Acuity enhancement
- Auditory enhancement
- Bodily control enhancement
- Colour enhancement
- Visual acuity enhancement
- Increased music appreciation
- Auditory acuity enhancement
Negative
- Disinhibition
- Acuity suppression
- Auditory suppression
- Double vision
- Frame rate suppression
- Pattern recognition suppression
- Dehydration
- Tactile suppression
- Appetite suppression
- Visual acuity suppression
- Spatial disorientation
- Auditory acuity suppression
- Visual disconnection
- Auditory distortion
- Auditory hallucinations
- Autonomous entities
- Environmental cubism
- Environmental orbism
- Internal hallucinations
- Perception of decreased weight
- Scenery slicing
- Auditory hallucination
- Vibrating vision
- Internal hallucination
- Olfactory hallucination
- Optical sliding
- Perspective hallucination
- Tactile intensification
- Appetite intensification
- Visual processing deceleration