Background 25 year old U.S. male living in major urban city center. 10 years of experience with various psychoactive substances, including 5 years of experience specifically with non-psychedelic stimulants.
3,4-Dichloromethylphenidate
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- PubChem toxicity data
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- PubChem toxicity data
- classified Research-chemical
Aliases: 3,4-ctmp, 3,4-dcmp, Dichloromethylphenidate, 34ctmp
Summary
3,4-Dichloromethylphenidate (3,4-CTMP) is a stimulant of the substituted phenidate class, used as a research chemical. It is approximately seven times more potent than methylphenidate and has a significantly longer duration of 6-18 hours. A critical safety concern is its agonist activity at 5-HT2B receptors, which can cause pulmonary hypertension and heart valve fibrosis with repeated use. Insufflation is strongly discouraged, as the substance has low water solubility, is extremely caustic to nasal tissues, and has poor absorption leading to delayed onset that increases overdose risk.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 2-4mg | 4-6mg | 6-8mg | 8mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 1-2 hrs | 3-6 hrs | 4-8 hrs | 4-18 hrs |
Effect Profile
5 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Stimulant
6.4
Strong
6/10
Strong anxiety/jitters, euphoria, and focus with mild stimulation
Stimulation / Energy
×3
5
stimulation
wakefulness
Euphoria / Mood Lift
×2
9
euphoria
cognitive euphoria
mood lift
motivation enhancement
Focus / Productivity
×2
9
focus enhancement
analysis enhancement
motivation enhancement
thought acceleration
Anxiety / Jitters
×1
10
anxiety
paranoia
increased heart rate
teeth grinding
bruxism
vasoconstriction
+1 more
Based on reports from:
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute tolerance; longer for full reset
Tolerance Decay
Full tolerance
1d
Half tolerance
10d
Baseline
~18d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Aggregated from 5 Erowid experience reports
Positive Effects 2
Focus Enhancement
80.0%
70%
Stimulation
80.0%
70%
Adverse Effects 1
Increased Heart Rate
100.0%
70%
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 4 reports 3 neutral 1 cautionary visit
Today I received a 500mg sample of 3,4-dichlormethylphenidate HCl (hereafter 3,4-CTMP), and I must say I am pleasantly surprised by how tolerable its exceptional power has been.
Set: Expected a relatively boring stimulant, as most are. Setting: Home, the store, parents', home again. Foreward: Quick rundown, I've tried Ethylphenidate, Isopropylphenidate, Methylphenidate, and HDMP-28 (out of this general family). Although ethylphenidate was fun, it did not help my attention span.
[There is, apparently, some concern that due to 5-HT2B receptor agonism, this drug can cause pulmonary hypertension, a very dangerous heart condition. That's certainly possible, and some 5-HT2B agonists (such as aminorex) have been linked to the condition, but many others (such as guanfacine, xylometazoline, and even L...
3,4-Dichloromethylphenidate's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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