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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-AcO-DET

    Aliases: Ethacetin, Ethylacybin, 4-acetoxy-det

    Psychedelic Research-chemical

    Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

    4-AcO-DET is a rare psychedelic tryptamine first synthesized by Albert Hofmann in 1958. It is believed to act as a prodrug for 4-HO-DET (ethocin). Effects are similar to psilocin, though some users report it being more stimulating and anxiety-inducing than other 4-substituted tryptamines.

    Perspectives

    “4-AcO-DET is a short trip. It's less introspective and more outrospective. You find yourself hyperanalyzing everything.”

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 10-15mg 15-20mg 20-35mg 35mg+
    Smoked 5-10mg - - -
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects
    Oral 19-60 min 60-90 min 1.5-3 hrs 1-2 hrs 2-4 hrs

    Effect Profile

    50 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 50 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 8.8
    Intense+ 9/10

    Strong visuals, headspace, auditory effects, and body load

    Visual Intensity ×3
    10
    color enhancement tracers drifting visual enhancement pattern recognition enhancement color shifting +3 more
    Headspace Depth ×3
    10
    conceptual thinking thought connectivity emotion enhancement personal bias suppression time distortion
    Auditory Effects ×1
    10
    auditory distortion auditory hallucination
    ⚠ Body Load / Somatic Effects ×1
    10
    nausea bodily pressures teeth grinding
    Based on reports from:
    Effect Index Shaking a Lot Effect Index First Experiment with 4-AcO-DET Effect Index First Impressions of 4-AcO-DET Effect Index My Skin Didn't Look Like This Before Effect Index My Second Experience with 4-AcO-DET
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 6h Half tolerance 3d Baseline ~14d

    Estimates inferred from classical psychedelic patterns (psilocybin/LSD) and user reports; quality anecdotal. Avoid redosing to chase effects during the same session due to tolerance spikes and unpredictability.

    Cross-Tolerances

    Psilocybin/Psilocin (4-HO-DMT)
    60%
    LSD
    50%
    Other 4-substituted tryptamines (e.g., 4-HO/4-AcO-MET/MiPT)
    60%

    Effects Erowid

    Aggregated from 50 Erowid experience reports

    Positive Effects 10

    Music Enhancement 52.0% 70%
    Color Enhancement 50.0% 70%
    Stimulation 46.0% 70%
    Tactile Enhancement 44.0% 70%
    Empathy 42.0% 70%
    Introspection 32.0% 70%
    Euphoria 32.0% 70%
    Focus Enhancement 20.0% 70%
    Body High 18.0% 70%
    Creativity Enhancement 6.0% 70%

    Adverse Effects 9

    Anxiety 48.0% 70%
    Nausea 32.0% 70%
    Muscle Tension 30.0% 70%
    Confusion 28.0% 70%
    Jaw Clenching 14.0% 70%
    Pupil Dilation 8.0% 70%
    Sweating 6.0% 70%
    Increased Heart Rate 6.0% 70%
    Motor Impairment 6.0% 70%

    Combinations TripSit

    Trip Reports Effect Index

    Shaking a Lot nervewing First Experiment with 4-AcO-DET Josie First Impressions of 4-AcO-DET Natalie My Skin Didn't Look Like This Before Natalie My Second Experience with 4-AcO-DET Josie
    4-AcO-DET's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 Bluelight 📖 PsychonautWiki