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4-AcO-MET Stats & Data

Psychedelic Research-chemical

Metacetin 4-acetoxy-met O-acetylmetocin 4acomet

PubChem CID 71308138

NPS DataHub

MW260.34

FormulaC15H20N2O2

CAS1445751-40-5

IUPAC3-(2-Ethyl(methyl)aminoethyl)-1''H''-indol-4-yl acetate

SMILESCCN(C)CCc1cnc2cccc(OC(C)=O)c12

InChIKeyOMDKHOOGGJRLLX-UHFFFAOYSA-N

Tryptamines; 2020/5.1 Indol-3-alkylamine; 2021/5.1 Indol-3-alkylamine; 2022/5.1 Indol-3-alkylamine

Chemical Class Tryptamine

Psychoactive Class Psychedelic

Pharmacology

DrugBank

History & Culture

4-AcO-MET, also known as metacetin, is a novel synthetic tryptamine that emerged primarily through the online research chemical market. As an acetate ester of 4-HO-MET and a structural homologue of 4-AcO-DMT, it represents one of many acetylated tryptamine derivatives that have been synthesized and distributed in recent decades. The compound has very little documented history of human use compared to more established psychedelics. Unlike substances such as psilocybin or LSD, which have decades of clinical research and cultural significance, 4-AcO-MET remains relatively obscure with minimal data regarding its pharmacological properties, metabolism, or toxicity profile. Its availability has been primarily limited to online research chemical vendors, where it is marketed alongside other novel tryptamine analogues.

Subjective Effect Notes

cognitive: The cognitive effects of 4-AcO-MET are described by many as somewhat relaxing, yet fast-paced in style with similarities to psychedelics such as LSD or 2C-B which tend to be cognitively energetic and stimulating.

Toxicity

PsychonautWiki

The toxicity and long-term health effects of recreational 4-AcO-MET use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-AcO-MET is a research chemical with very little history of human usage. Anecdotal evidence suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption. It is strongly recommended that one use harm reduction practices when using this substance.

Effect Profile

Curated + 36 Reports

Psychedelic 8.8

Strong visuals, headspace, auditory effects, and body load

Visual Intensity×3

10107.5

Headspace Depth×3

10102.6

Auditory Effects×1

10102.6

Body Load / Somatic Effects×1

10103.4

Catalog Erowid BlueLight

Based on reports from:

Effect Index Resplendent and Warm — nervewing Effect Index Dying from a Cosmic Slap — froggie Effect Index Warm and Arrogant Feeling — froggie Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki 4-AcO-MET

Tolerance & Pharmacokinetics

drugs.wiki

Tolerance Decay

Full tolerance 1h Half tolerance 10d Baseline ~14d

Cross-Tolerances

LSD

80% ●○○

Psilocybin

85% ●○○

Psilocin

85% ●○○

Mescaline

65% ●○○

DMT

85% ●○○

5-MeO-DMT

85% ●○○

2C-B

65% ●○○

2C-E

65% ●○○

Experience Report Analysis

Erowid BlueLight

23 Reports

2013–2025 Date Range

21 With Age Data

26 Effects Detected

Demographics

Gender Distribution

Age Distribution

Reports Over Time

Effect Analysis

Erowid + Bluelight

Effects aggregated from 36 experience reports (23 Erowid + 13 Bluelight)

36 Reports

90 Effects Detected

48 Positive

26 Adverse

16 Neutral

Effect Sentiment Distribution

Confidence Distribution

Positive Effects 48

Color Enhancement 69.5% 89%

Stimulation 60.9% 70%

Patterning 53.8% 87%

Empathy 52.2% 70%

Focus Enhancement 47.8% 70%

Music Enhancement 47.2% 88%

Euphoria 47.2% 89%

Introspection 41.7% 82%

Entity Imagery 38.5% 86%

Geometric Imagery 38.5% 88%

Contentment 38.5% 78%

Joy 30.8% 89%

Morphing 30.8% 86%

Surface Breathing 30.8% 84%

Warping 23.1% 85%

Awe 23.1% 83%

Peace 23.1% 82%

Tactile Enhancement 19.5% 75%

Body High 19.4% 90%

Fractal Imagery 15.4% 88%

Adverse Effects 26

Anxiety 38.9% 83%

Nausea 33.4% 88%

Thought Disorganization 30.8% 76%

Muscle Tension 27.8% 75%

Confusion 25.0% 85%

Body Load 23.1% 78%

Chills 23.1% 77%

Sweating 16.6% 75%

Thought Acceleration 15.4% 78%

Fear 15.4% 75%

Insomnia 15.4% 82%

Dysphoria 15.4% 78%

Headache 13.9% 80%

Increased Heart Rate 13.0% 70%

Jaw Clenching 13.0% 70%

Pupil Dilation 11.1% 80%

Pressure 7.7% 80%

Memory Suppression 7.7% 80%

Focus Suppression 7.7% 85%

Panic 7.7% 75%

Dosage Distribution

Dose distribution from experience reports

Median: 20.0 mg IQR: 15.0–30.0 mg n=13

Real-World Dose Distribution

62K Doses

From 44 individual dose entries

Oral (n=38)

Median: 22.5mg 25th: 13.5mg 75th: 31.5mg 90th: 40.0mg

mg/kg median: 0.289 mg/kg 75th: 0.481

Common Combinations

Most co-occurring substances in experience reports

Form / Preparation

Most common forms and preparations reported

Body-Weight Dosing

Dose relative to body weight from reports with weight data

Median: 0.284 mg/kg IQR: 0.22–0.508 mg/kg n=13

Redose Patterns

Redosing behavior across 13 reports

15.4% Redosed

1.3 Avg Doses

60m Median Interval

Read full reports on Erowid →

Legal Status

Country	Status	Notes
Germany	NpSG (Controlled)	Controlled under the Neue-psychoaktive-Stoffe-Gesetz (New Psychoactive Substances Act) as of July 18, 2019. Production, import with intent to market, administration to others, and trading are punishable offenses. Possession is illegal but not subject to criminal penalty. Ordering may potentially constitute incitement to place on the market.
Switzerland	Controlled (Verzeichnis E)	Specifically named as a controlled substance under Verzeichnis E of Swiss narcotics legislation.
United Kingdom	Class A	Controlled as a Class A substance under the Misuse of Drugs Act 1971. Classification stems from being an ester of 4-HO-MET, which itself is controlled under the tryptamine catch-all clause.
United States	Unscheduled	Not specifically scheduled under the Controlled Substances Act. However, as a structural analogue of psilocin (a Schedule I substance), sale for human consumption or use for illicit non-medical purposes could potentially be prosecuted under the Federal Analogue Act.

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