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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-AcO-MET

    Aliases: Metacetin, 4-acetoxy-met, O-acetylmetocin, 4acomet

    Psychedelic Research-chemical

    Summary PsychonautWiki

    4-Acetoxy-N-methyl-N-ethyltryptamine (also known as 4-AcO-MET, Metacetin, and Azomet) is a lesser-known novel psychedelic substance of tryptamine class. Members of this group produce psilocybin-like psychedelic effects when administered. It is structurally related to psychedelic tryptamines like 4-AcO-DMT, 4-AcO-DET, and 4-AcO-MiPT.

    Dose Information TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 10-20mg 20-30mg 30-50mg 50mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 18-60 min 30-60 min 1-2 hrs 2-2 hrs 2-4 hrs 4-6 hrs

    Effect Profile

    36 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 23 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 8.8
    Intense+ 9/10

    Strong visuals, headspace, auditory effects, and body load

    Visual Intensity ×3
    10
    internal hallucinations autonomous entities colour enhancement drifting tracers colour shifting +6 more
    Headspace Depth ×3
    10
    conceptual thinking thought connectivity feelings of interdependent opposites subconscious communication emotion enhancement perspective alterations +5 more
    Auditory Effects ×1
    10
    auditory distortion auditory enhancement auditory hallucinations auditory hallucination
    ⚠ Body Load / Somatic Effects ×1
    10
    nausea muscle tension teeth grinding
    Based on reports from:
    Effect Index Resplendent and Warm Effect Index Dying from a Cosmic Slap Effect Index Warm and Arrogant Feeling Bluelight Big & Dandy Thread Erowid Experience Reports
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Cross-Tolerances

    Lysergamides
    LSD
    80%
    Tryptamines
    Psilocybin
    85%
    Psilocin
    85%
    DMT
    85%
    5-MeO-DMT
    85%
    Phenethylamines
    Mescaline
    65%
    2C-B
    65%
    2C-E
    65%

    Effects Erowid Bluelight

    Aggregated from 23 Erowid and 13 Bluelight experience reports

    Positive Effects 50

    Color Enhancement 69.5% 89%
    Stimulation 60.9% 70%
    Closed-Eye Visuals 55.6% 92%
    Patterning 53.8% 87%
    Empathy 52.2% 70%
    Focus Enhancement 47.8% 70%
    Euphoria 47.2% 89%
    Music Enhancement 47.2% 88%
    Open-Eye Visuals 44.4% 90%
    Introspection 41.7% 82%
    Entity Imagery 38.5% 86%
    Geometric Imagery 38.5% 88%
    Contentment 38.5% 78%
    Joy 30.8% 89%
    Morphing 30.8% 86%
    Surface Breathing 30.8% 84%
    Warping 23.1% 85%
    Awe 23.1% 83%
    Peace 23.1% 82%
    Tactile Enhancement 19.5% 75%

    Adverse Effects 25

    Anxiety 38.9% 83%
    Sedation 36.1% 82%
    Nausea 33.4% 88%
    Thought Disorganization 30.8% 76%
    Confusion 25.0% 85%
    Body Load 23.1% 78%
    Chills 23.1% 77%
    Sweating 16.6% 75%
    Thought Acceleration 15.4% 78%
    Fear 15.4% 75%
    Insomnia 15.4% 82%
    Dysphoria 15.4% 78%
    Headache 13.9% 80%
    Increased Heart Rate 13.0% 70%
    Jaw Clenching 13.0% 70%
    Pressure 7.7% 80%
    Memory Suppression 7.7% 80%
    Focus Suppression 7.7% 85%
    Panic 7.7% 75%
    Paranoid Ideation 7.7% 85%

    Combinations TripSit

    Trip Reports Effect Index

    Resplendent and Warm nervewing Dying from a Cosmic Slap froggie Warm and Arrogant Feeling froggie
    4-AcO-MET's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TripSit 📖 PsychonautWiki 📖 Bluelight