4-Bromomethcathinone
Aliases: 4-bmc, 4-bmap, Brephedrone, 4-bromo-n-methylcathinone
Summary
4-Bromomethcathinone (4-BMC; brephedrone) is a brominated analog of methcathinone with a unique pharmacological profile among stimulant cathinones. Laboratory studies demonstrate it acts primarily as a potent serotonin reuptake inhibitor—approximately 15-fold more effective than methcathinone at SERT—alongside serotonin-norepinephrine-dopamine releasing properties, explaining its reputation for producing empathogenic effects rather than typical stimulation. User reports consistently describe calm euphoria and antidepressant-like feelings at moderate to strong doses, with minimal physical stimulation.
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral | 30-60 min | 30-45 min | 1-2 hrs | 1-2 hrs |
| Insufflated | 10-30 min | 20-30 min | 1-2 hrs | 1-2 hrs |
| Rectal | 15-30 min | 30-45 min | 1-2 hrs | 1-2 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria, sensory enhancement, and stimulation with moderate empathy
Strong euphoria and anxiety/jitters with mild stimulation, low focus
Tolerance
Tolerance Decay
Anecdotal patterns suggest noticeable acute tolerance after a session, partial recovery by ~3–7 days, and return to baseline within ~2–4 weeks. Given serotonergic mechanism and para‑halogenation toxicity concerns, longer spacing (≥6–8 weeks) is prudent despite limited direct data.
Cross-Tolerances
Effects
- Stimulation
- Physical euphoria
- Increased energy
- Pupil dilation
- Teeth grinding
- Increased perspiration
- Increased heart rate
- Insomnia
- Increased blood pressure
- Increased body temperature
- Euphoria
- Empathy enhancement
- Sociability enhancement
- Emotional enhancement
- Anxiety suppression
- Cognitive euphoria
- Motivation enhancement
- Increased sociability
- Compulsive redosing
- Anxiety
- Motivation suppression
- Talkativeness
- Increased music appreciation
- Music enhancement
- Color enhancement
- Increased libido
- Tactile enhancement
- Disinhibition
- Appetite suppression
- Dehydration
- Vibrating vision
- Spontaneous physical sensations