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    4-CBC molecular structure

    4-CBC Stats & Data

    NPS DataHub
    MW276.21
    FormulaC13H19Cl2NO
    IUPAChydrogen 2-(butylamino)-1-(4-chlorophenyl)propan-1-one chloride
    SMILES[Cl-].CCCCNC(C)C(=O)c1ccc(Cl)cc1.[H+]
    InChIKeyDKPILUWUWJLVPE-UHFFFAOYSA-N
    Phenethylamines; 2020/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2021/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2022/1. Von 2-Phenethylamin abgeleitete Verbindungen
    Chemical Class Cathinone
    Psychoactive Class Stimulant / Entactogen
    Half-Life Estimated 3–6 h in plasma based on structural analogues; no formal human PK study.

    Receptor Profile

    Receptor Actions

    Inhibitors
    Dopamine-norepinephrine reuptake inhibitor (NDRI)
    Other
    Dopamine-norepinephrine releasing agent (DNRA)
    Serotonin releasing agent (partial)

    Effect Profile

    Curated
    Empathogen 7.1

    Strong sensory enhancement and euphoria with moderate stimulation, mild empathy

    Empathy / Social Openness×3
    5
    Euphoria / Mood Elevation×2
    9
    Stimulation×1
    7
    Sensory Enhancement×1
    10
    Stimulant 6.1

    Strong euphoria and anxiety/jitters with moderate focus, mild stimulation

    Stimulation / Energy×3
    5
    Euphoria / Mood Lift×2
    10
    Focus / Productivity×2
    7
    Anxiety / Jitters×1
    10

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Estimated 3–6 h in plasma based on structural analogues; no formal human PK study.
    Addiction Potential
    Moderate–high. Short duration and dopaminergic action promote compulsive redosing; binge patterns and tolerance comparable to mephedrone and 4-CMC.

    Tolerance Decay

    Full tolerance 2d Half tolerance 7d Baseline ~14d

    Cathinone-class tolerance tends to build quickly with daily or binge use and decays over 1–3+ weeks. Cross-tolerance within dopaminergic releasers is probable though incompletely quantified; values are heuristic from user patterns rather than controlled studies.

    Cross-Tolerances

    Other cathinones (e.g., 4-CMC, mephedrone)
    60% ●●○
    Amphetamines
    30% ●○○
    Cocaine
    20% ●○○

    Harm Reduction

    drugs.wiki

    • ID and purity: 4-CBC appears on the market alongside other 3-/4-halogenated cathinones; reagent tests are not definitive for identity—use GC–MS/LC–MS when possible and treat untested powders as unknown potency. • Dosing discipline: Use a milligram scale; avoid 'eyeballing' due to narrow comfort-to-adverse range. Begin with a 1–5 mg allergy test and wait a full onset window before any further dosing. • Redosing: Because effects are short and dopaminergic, limit sessions to ≤250 mg total and ≥3 h between doses to reduce compulsive binges and cardiostrain. • Hydration/temperature: Sip 250–500 ml isotonic fluid per hour during exertion; avoid overdrinking plain water to reduce hyponatremia risk. Take cooling breaks in hot environments. • Cardiovascular caution: Expect tachycardia, BP elevation, and vasoconstriction; avoid if you have uncontrolled hypertension, arrhythmia, or cardiovascular disease. Seek urgent care for chest pain, severe headache, or temperature >38.5°C. • Seizures: Stimulants and several common meds (e.g., tramadol, bupropion) reduce seizure threshold; avoid polydrug use in this category and stop use if aura or myoclonus appears. • Nasal harm: Insufflation increases local irritation and compulsive redosing; if used intranasally, employ small lines, space doses, and rinse with sterile saline after. Prefer oral dosing for lower mucosal harm. • Mental health: Anxiety, low mood, and anhedonia are common during the comedown; avoid use if you have active psychosis, bipolar mania, or severe anxiety disorders. Ensure post-use sleep, nutrition, and social support. • Sleep agents: Avoid mixing with alcohol, opioids, or high-dose benzodiazepines to 'come down'—this increases respiratory and decision-risk; if sedation is needed, wait until heart rate and BP normalize and use only minimal doses under medical guidance. • Tolerance/spacing: Allow at least 2 weeks between sessions; frequent use rapidly raises tolerance and worsens mood crashes. • Drug checking: Some halogenated cathinones share similar reagent colors; confirmatory lab testing (FTIR/GC–MS/LC–MS) is strongly recommended, especially to distinguish from 4-CMC/3-CMC.

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