4-EPD
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- classified Tentative
- classified Research-chemical
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- classified Tentative
- classified Research-chemical
Aliases: P-epd, 4-ethylpentedrone, Para-ethyl pentedrone, 4-ethyl-alpha-methylamino-valerophenone
Summary
4-EPD is a ring-ethyl analogue of pentedrone first detected in European drug-checking samples in 2018. Toxicological information is sparse; a handful of fatal intoxications have been documented, usually with poly-drug use. Acute risks mirror those of other potent cathinones: tachycardia, hypertension, hyperthermia, rhabdomyolysis, hyponatremia from excessive water intake, acute psychosis, and serotonin syndrome when mixed with serotonergics.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated | 10-20mg | 20-30mg | 30-50mg | 50mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 20-45 min | 30-90 min | 1-2 hrs | 1-3 hrs |
| Insufflated | 5-30 min | 30-90 min | 1-2 hrs | 1-3 hrs |
| Rectal | 5-15 min | 30-90 min | 1-2 hrs | 1-3 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong anxiety/jitters with moderate euphoria, mild focus, low stimulation
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track 4-EPD there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
4-EPD Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 10 Insufflated dose (mg): light 10-20 · common 20-30 · strong 30-50 · heavy 50+ Rectal dose (mg): threshold 8 Oral duration: onset 20-45m · peak 0.5-1.5h · offset 1-2h · total 1-3h · after-effects 2-8h Insufflated duration: onset 5-30m · peak 0.5-1.5h · offset 1-2h · total 1-3h · after-effects 2-8h Rectal duration: onset 5-15m · peak 0.5-1.5h · offset 1-2h · total 1-3h · after-effects 2-8h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 25 mg (Insufflated).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
- Stimulation
- Increased heart rate
- Teeth grinding
- Vasoconstriction
- Insomnia
- Pupil dilation
- Nausea
- Elevated blood pressure
- Sedation
- Decreased appetite
- Euphoria
- Motivation enhancement
- Increased sociability
- Focus enhancement
- Empathy enhancement
- Cognitive euphoria
- Compulsive redosing
- Anxiety
- Anxiolysis or Anxiety
- Time distortion
- Tactile enhancement
- Color enhancement
- Increased music appreciation
- Brightened colour
- Appetite suppression
- Disinhibition
- Light sensitivity
- Dehydration
- Dulled perception
- Drifting
Combinations
Cross-Check 4-EPD with another substanceHelpful Links
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