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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-FMC

    Aliases: Drone, 4f-mcat, Flephedrone, Fpephedrone, 4-fluoromethcathinone, 4fmc

    Stimulant Research-chemical

    Summary TheDrug.Wiki Erowid TripSit

    Pentedrone is a Schedule I controlled substance in the United States and is illegal in many countries. The toxicity and long-term health effects have not been studied in scientific contexts, and exact toxic dosage is unknown. Use accurate milligram scales for dosing.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 50-100mg 100-150mg 150-200mg 200mg+
    Insufflated 25-40mg 50-100mg 100-150mg 150mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects
    Oral 20-40 min 30-60 min 1-2 hrs 30-60 min 2-6 hrs
    Insufflated 5-10 min 15-30 min 30-90 min 30-60 min 2-6 hrs

    Effect Profile

    3 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Empathogen 7.7
    Intense 8/10

    Strong euphoria and sensory enhancement with moderate empathy, mild stimulation

    Empathy / Social Openness ×3
    7
    empathy enhancement sociability enhancement increased sociability
    Euphoria / Mood Elevation ×2
    10
    physical euphoria euphoria cognitive euphoria mood lift
    Stimulation ×1
    5
    stimulation teeth grinding increased heart rate
    Sensory Enhancement ×1
    8
    tactile enhancement spontaneous tactile sensations increased libido
    Stimulant 4.9
    Moderate+ 5/10

    Strong euphoria and anxiety/jitters with mild focus, low stimulation

    Stimulation / Energy ×3
    3
    stimulation
    Euphoria / Mood Lift ×2
    10
    physical euphoria euphoria cognitive euphoria mood lift motivation enhancement
    Focus / Productivity ×2
    5
    focus enhancement motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety paranoia teeth grinding increased heart rate bruxism vasoconstriction +1 more
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 4-FMC
    View methodology →

    Tolerance

    Build-up develops rapidly, often within a single session; compulsive redosing common
    Reset a few days for acute tolerance

    Tolerance Decay

    Full tolerance 2d Half tolerance 7d Baseline ~28d

    Tolerance to entactogenic/stimulant effects appears to build rapidly across a single day and decays over 1–6 weeks. Values are rough, inferred from user reports for short‑acting cathinones; data quality is anecdotal.

    Cross-Tolerances

    Other stimulants (amphetamines, cathinones)
    50%

    Effects TheDrug.Wiki TripSit

    Positive
    • Stimulation
    • Physical euphoria
    • Spontaneous tactile sensations
    • Increased energy/alertness
    Negative
    • Teeth grinding
    • Vasoconstriction
    • Increased heart rate
    • Insomnia
    • Weight loss
    • Sweating
    • Bruxism
    Neutral
    • Difficulty urinating
    • Decreased need for sleep
    • Decreased appetite
    • Disturbed sleep patterns
    • Itchiness
    Positive
    • Euphoria
    • Empathy enhancement
    • Sociability enhancement
    • Motivation enhancement
    • Cognitive Euphoria
    • Focus Enhancement
    • Increased sociability
    • Mood lift
    Negative
    • Anxiety
    • Compulsive redosing
    • Paranoia
    • Aggressiveness
    Neutral
    • Time distortion
    • Excessive talking
    • Moodiness
    Positive
    • Increased libido
    • Increased music appreciation
    • Tactile enhancement
    Negative
    • Disinhibition
    • Dehydration
    • Appetite Suppression
    • Appetite suppression
    Neutral
    • Spontaneous Physical Sensations
    • Increased sexuality
    • Visual and auditory hallucinations

    Combinations TripSit

    4-FMC's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki