4-FPP
Aliases: Pfpp, Fluoperazine, Flipiperazine, Para-fluorophenylpiperazine
Summary
4-FPP was first identified as a urinary metabolite of the sedative niaprazine in 1982 and subsequently sold (2003-2008) in New Zealand "party pills" together with BZP under brand names including "The Big Grin," "Mashed," and "Extreme Beans." In vitro, it is a high-efficacy 5-HT1A agonist (Ki ≈ 11 nM), moderate 5-HT2A/2C partial agonist, and weak SERT/NET releaser. DAT activity is negligible, explaining its low stimulant euphoria compared to BZP. Subjectively, it produces light empathic warmth, mild color enhancement/tracers, and prominent vasoconstrictive "head pressure." Nausea, migraine-like headaches, myalgia, and anxiety are common above ~100 mg.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 20-40mg | 40-80mg | 80-150mg | 150mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 15-45 min | 30-60 min | 1-3 hrs | 1-2 hrs | 2.8-6.8 hrs |
| Insufflated | 5-15 min | 15-30 min | 1-3 hrs | 1-2 hrs | 2.3-5.8 hrs |
| Rectal | 10-20 min | 20-40 min | 1-3 hrs | 1-2 hrs | 2.5-6 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong body load with mild visuals
Moderate stimulation and empathy with mild euphoria, low sensory enhancement
Strong anxiety/jitters with moderate stimulation, mild euphoria
Tolerance
Tolerance Decay
Tolerance and cross-tolerance estimates are anecdotal and extrapolated from related phenylpiperazines and serotonergic empathogens; space uses by at least 2–3 weeks to reduce blunting and after-effects.
Cross-Tolerances
Effects
- Stimulation
- Physical stimulation
- Pupil Dilation
- Vasoconstriction
- Muscle Tension
- Teeth Grinding
- Nausea
- Headache
- Lethargy
- Brightness Alteration
- Empathy Enhancement
- Euphoria
- Alertness enhancement
- Mood lift
- Empathy enhancement
- Anxiety
- Dysphoria
- Drowsiness
- Talkativeness
- Feelings of Impending Doom
- Color Enhancement
- Tracers
- Light sensitivity
- Appetite Suppression
- Decreased Libido
- Dehydration
- Closed-Eye Visuals
- Visual Drifting
- Perception of Bodily Heaviness
- Visual distortions