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    ☠ This substance has been associated with serious adverse events including fatalities. Use extreme caution.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-FPP

    Aliases: Pfpp, Fluoperazine, Flipiperazine, Para-fluorophenylpiperazine

    Categories

    Psychedelic Stimulant Empathogen Research-chemical
    4-FPP structure

    Summary TheDrug.Wiki TripSit

    4-FPP was first identified as a urinary metabolite of the sedative niaprazine in 1982 and subsequently sold (2003-2008) in New Zealand "party pills" together with BZP under brand names including "The Big Grin," "Mashed," and "Extreme Beans." In vitro, it is a high-efficacy 5-HT1A agonist (Ki ≈ 11 nM), moderate 5-HT2A/2C partial agonist, and weak SERT/NET releaser. DAT activity is negligible, explaining its low stimulant euphoria compared to BZP. Subjectively, it produces light empathic warmth, mild color enhancement/tracers, and prominent vasoconstrictive "head pressure." Nausea, migraine-like headaches, myalgia, and anxiety are common above ~100 mg. Unlike BZP, 4-FPP inhibits several hepatic CYPs (notably 1A2, 2D6, 3A4), which can prolong co-administered drugs. Rodent LD50 (oral) ≈ 400 mg/kg; no confirmed fatalities as sole agent, but severe hyperthermia, seizures, and rhabdomyolysis have been reported in polydrug cases.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 20-40mg 40-80mg 80-150mg 150mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 15-45 min 30-60 min 1-3 hrs 1-2 hrs 2-12 hrs 240-0 min
    Insufflated 5-15 min 15-30 min 1-3 hrs 1-2 hrs 2-12 hrs 240-0 min
    Rectal 10-20 min 20-40 min 1-3 hrs 1-2 hrs 2-12 hrs 240-0 min

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    • Physical stimulation
    Negative
    • Pupil Dilation
    • Vasoconstriction
    • Muscle Tension
    • Teeth Grinding
    • Nausea
    • Headache
    • Lethargy
    Neutral
    • Brightness Alteration
    Positive
    • Empathy Enhancement
    • Euphoria
    • Alertness enhancement
    • Mood lift
    • Empathy enhancement
    Negative
    • Anxiety
    • Dysphoria
    • Drowsiness
    Neutral
    • Talkativeness
    • Feelings of Impending Doom
    Positive
    • Color Enhancement
    • Tracers
    Negative
    • Light sensitivity
    • Appetite Suppression
    • Decreased Libido
    • Dehydration
    Neutral
    • Closed-Eye Visuals
    • Visual Drifting
    • Perception of Bodily Heaviness
    • Visual distortions

    Combinations TripSit

    Helpful Links

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