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    4-HO-DET molecular structure

    4-HO-DET Stats & Data

    Psychedelic Research-chemical
    Cz-74 Ethocin 4hodet 4-hydroxy-det
    PubChem CID 9991554
    NPS DataHub
    MW232.33
    FormulaC14H20N2O
    CAS22204-89-3
    IUPAC3-(2-diethylaminoethyl)-1H-indol-4-ol
    SMILESCCN(CC)CCc1cnc2cccc(O)c12
    InChIKeyOHHYMKDBKJPILO-UHFFFAOYSA-N
    Tryptamines; 2020/5.1 Indol-3-alkylamine; 2021/5.1 Indol-3-alkylamine; 2022/5.1 Indol-3-alkylamine
    Chemical Class Tryptamine
    Psychoactive Class Psychedelic

    Pharmacology

    DrugBank

    Receptor Profile

    Receptor Actions

    Agonists
    5-HT2A receptor agonist
    5-HT2B receptor agonist
    5-HT2C receptor agonist
    Inhibitors
    Serotonin reuptake inhibitor (low affinity)

    Toxicity

    PsychonautWiki

    The toxicity and long-term health effects of recreational 4-HO-DET use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-HO-DET is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-HO-DET suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption. It is strongly recommended that one use harm reduction practices when using this substance.

    Effect Profile

    Curated + 18 Reports
    Psychedelic 8.8

    Strong visuals, headspace, auditory effects, and body load

    Visual Intensity×3
    10
    Headspace Depth×3
    10
    Auditory Effects×1
    10
    Body Load / Somatic Effects×1
    10
    Based on reports from:
    Effect Index I Am Doing Nothing — nervewing TiHKAL TiHKAL #16: 4-HO-DET Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki 4-HO-DET

    Duration Timeline

    Bluelight
    Onset Comeup Peak Offset After Effects
    Oral
    19-45 minutes
    30 minutes - 1.0 hours
    2.5-3.5 hours
    1.5-2 hours
    1-4 hours
    Total: 3-7 hours
    Intravenous
    30-60 minutes hours
    1-12 hours
    Total: 3-7 hours
    Smoked
    0 minutes
    1-12 hours
    Total: 3-7 hours

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Cross-Tolerances

    LSD
    80% ●○○
    Psilocybin
    85% ●○○
    Psilocin
    85% ●○○
    Mescaline
    65% ●○○
    DMT
    85% ●○○
    5-MeO-DMT
    85% ●○○
    2C-B
    65% ●○○
    2C-E
    65% ●○○

    Experience Report Analysis

    Erowid
    18 Reports
    2004–2020 Date Range
    8 With Age Data
    21 Effects Detected

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Effect Analysis

    Erowid

    Effects aggregated from 18 experience reports (18 Erowid)

    18 Reports
    21 Effects Detected
    9 Positive
    5 Adverse
    7 Neutral

    Effect Sentiment Distribution

    Confidence Distribution

    Positive Effects 9

    Color Enhancement 61.1% 70%
    Stimulation 61.1% 70%
    Music Enhancement 55.6% 70%
    Focus Enhancement 50.0% 70%
    Euphoria 44.4% 70%
    Introspection 38.9% 70%
    Empathy 38.9% 70%
    Tactile Enhancement 38.9% 70%
    Body High 27.8% 70%

    Adverse Effects 5

    Confusion 61.1% 70%
    Muscle Tension 38.9% 70%
    Nausea 27.8% 70%
    Anxiety 27.8% 70%
    Pupil Dilation 16.7% 70%

    Dosage Distribution

    Dose distribution from experience reports

    Median: 25.0 mg IQR: 25.0–30.0 mg n=11

    Real-World Dose Distribution

    62K Doses

    From 20 individual dose entries

    Oral (n=18)

    Median: 25.0mg 25th: 25.0mg 75th: 30.0mg 90th: 35.9mg
    mg/kg median: 0.394 mg/kg 75th: 0.519

    Form / Preparation

    Most common forms and preparations reported

    Redose Patterns

    Redosing behavior across 13 reports

    0.0% Redosed
    1.0 Avg Doses
    Read full reports on Erowid →

    Legal Status

    Country Status Notes
    Finland Scheduled in the "government decree on psychoactive substances banned from the consumer market".
    Germany 4-HO-DET is controlled under Anlage I BtMG ( Narcotics Act, Schedule I ), former: Opiumgesetz ( Opium Act ) as of February 25, 1967. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
    Sweden Sveriges riksdags health ministry Statens folkhälsoinstitut classified 4-HO-DET as "health hazard" under the act Lagen om förbud mot vissa hälsofarliga varor (translated Act on the Prohibition of Certain Goods Dangerous to Health) as of Nov 1, 2005, in their regulation SFS 2005:733 listed as 4-hydroxi-N,N-diethyltryptamin (4-HO-DET), making it illegal to sell or possess.
    Switzerland 4-HO-DET is a controlled substance specifically named under Verzeichnis E.
    United Kingdom 4-HO-DET is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.
    United States 4-HO-DET is unscheduled in the United States, but purchase, sale, or possession for human consumption could be prosecuted under the Federal Analogue Act.

    References

    Data Sources

    Cited References

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