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4-HO-DET Stats & Data

Psychedelic Research-chemical

Cz-74 Ethocin 4hodet 4-hydroxy-det

PubChem CID 9991554

NPS DataHub

MW232.33

FormulaC14H20N2O

CAS22204-89-3

IUPAC3-(2-diethylaminoethyl)-1H-indol-4-ol

SMILESCCN(CC)CCc1cnc2cccc(O)c12

InChIKeyOHHYMKDBKJPILO-UHFFFAOYSA-N

Tryptamines; 2020/5.1 Indol-3-alkylamine; 2021/5.1 Indol-3-alkylamine; 2022/5.1 Indol-3-alkylamine

Chemical Class Tryptamine

Psychoactive Class Psychedelic

Receptor Profile

Receptor Actions

Agonists

5-HT2A receptor agonist

5-HT2B receptor agonist

5-HT2C receptor agonist

Inhibitors

Serotonin reuptake inhibitor (low affinity)

Subjective Effects

Physical

Spontaneous tactile sensations
Bodily control enhancement
Increased heart rate
Nausea
Pupil dilation
Tactile enhancement

Cognitive

Analysis enhancement
Conceptual thinking
Delusions
Emotion enhancement
Immersion enhancement
Memory suppression
Ego death
Novelty enhancement
Personal bias suppression
Thought acceleration
Thought loops
Time distortion
Unity and interconnectedness
Wakefulness

Sensory

Auditory

Enhancements
Distortions
Hallucinations

Visual · Distortions

Drifting: (melting, breathing, morphing and flowing)
Colour shifting
Depth perception distortions
Perspective distortions
Symmetrical texture repetition
Tracers

Visual · Enhancements

Colour enhancement
Pattern recognition enhancement
Visual acuity enhancement

Visual · Hallucinatory States

Transformations
Internal hallucinations: (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots)

Forked from Subjective Effect Documentation work by Josie Kins, August 2016. Via dose.wiki (CC0).

Toxicity

PsychonautWiki

The toxicity and long-term health effects of recreational 4-HO-DET use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-HO-DET is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-HO-DET suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. It is strongly recommended that one use harm reduction practices when using this substance.

Effect Profile

Curated + 18 Reports

Psychedelic 8.8

Strong visuals, headspace, auditory effects, and body load

Visual Intensity×3

Headspace Depth×3

Auditory Effects×1

Body Load / Somatic Effects×1

Based on reports from:

Effect Index I Am Doing Nothing — nervewing TiHKAL TiHKAL #16: 4-HO-DET Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki 4-HO-DET

Duration Timeline

Bluelight

Onset Comeup Peak Offset After Effects

Oral

19-45 minutes

30 minutes - 1.0 hours

2.5-3.5 hours

1.5-2 hours

1-4 hours

Total: 3-7 hours

Intravenous

30-60 minutes hours

1-12 hours

Total: 3-7 hours

Smoked

0 minutes

1-12 hours

Total: 3-7 hours

Tolerance & Pharmacokinetics

drugs.wiki

Tolerance Decay

Full tolerance 1h Half tolerance 10d Baseline ~14d

Cross-Tolerances

LSD

80% ●○○

Psilocybin

85% ●○○

Psilocin

85% ●○○

Mescaline

65% ●○○

DMT

85% ●○○

5-MeO-DMT

85% ●○○

2C-B

65% ●○○

2C-E

65% ●○○

Experience Report Analysis

Erowid

18 Reports

2004–2020 Date Range

8 With Age Data

21 Effects Detected

Demographics

Gender Distribution

Age Distribution

Reports Over Time

Effect Analysis

Erowid

Effects aggregated from 18 experience reports (18 Erowid)

18 Reports

21 Effects Detected

9 Positive

5 Adverse

7 Neutral

Effect Sentiment Distribution

Confidence Distribution

Positive Effects 9

Color Enhancement 61.1% 70%

Stimulation 61.1% 70%

Music Enhancement 55.6% 70%

Focus Enhancement 50.0% 70%

Euphoria 44.4% 70%

Introspection 38.9% 70%

Empathy 38.9% 70%

Tactile Enhancement 38.9% 70%

Body High 27.8% 70%

Adverse Effects 5

Confusion 61.1% 70%

Muscle Tension 38.9% 70%

Nausea 27.8% 70%

Anxiety 27.8% 70%

Pupil Dilation 16.7% 70%

Dosage Distribution

Dose distribution from experience reports

Median: 25.0 mg IQR: 25.0–30.0 mg n=11

Real-World Dose Distribution

62K Doses

From 20 individual dose entries

Oral (n=18)

Median: 25.0mg 25th: 25.0mg 75th: 30.0mg 90th: 35.9mg

mg/kg median: 0.394 mg/kg 75th: 0.519

Form / Preparation

Most common forms and preparations reported

Redose Patterns

Redosing behavior across 13 reports

0.0% Redosed

1.0 Avg Doses

Read full reports on Erowid →

Legal Status

Country	Status	Notes
Finland	Scheduled in the "government decree on psychoactive substances banned from the consumer market".
Germany	4-HO-DET is controlled under Anlage I BtMG ( Narcotics Act, Schedule I ), former: Opiumgesetz ( Opium Act ) as of February 25, 1967.	It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
Sweden	Sveriges riksdags health ministry Statens folkhälsoinstitut classified 4-HO-DET as "health hazard" under the act Lagen om förbud mot vissa hälsofarliga varor (translated Act on the Prohibition of Certain Goods Dangerous to Health) as of Nov 1, 2005, in their regulation SFS 2005:733 listed as 4-hydroxi-N,N-diethyltryptamin (4-HO-DET), making it illegal to sell or possess.
Switzerland	4-HO-DET is a controlled substance specifically named under Verzeichnis E.
United Kingdom	4-HO-DET is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.
United States	4-HO-DET is unscheduled in the United States, but purchase, sale, or possession for human consumption could be prosecuted under the Federal Analogue Act.

References

Data Sources

Cited References

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