The shit is fucking crazy. I would put the general ambient vibe of the drug as an odd and unsettling cross between mushrooms and LSD. Definitely good shit, and I took a lot of it. Zero Hour. I and my friend R are fucking around in some music store in my hometown.
4-HO-DET
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
- classified Research-chemical
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
- classified Research-chemical
Aliases: Cz-74, Ethocin, 4hodet, 4-hydroxy-det
Summary
4-HO-DET is a research chemical with very little history of human usage. The toxicity and long-term health effects have not been studied in any scientific context. Compared to psilocin, 4-HO-DET has been reported to have a slightly longer duration, less pronounced bodily effects, and more synthetic or algorithmic-style visuals.
Perspectives
“This is perhaps one of the more boring psychedelics I have tasted. The experience does not lend itself to any meaningful thought processes or profound explorations of existence.”
“This was in a gelatin capsule and it came on from a half hour to the three-quarter hour point like gang-busters. Time really slowed down, with sparkly-ness, interesting, and yet there was a touch of sadness. The intense visuals held the scene, and there was the compulsion to talk and to interact and to share stuff, but the erotic was not to be found. I slept OK but there was something uncomfortable at a deep level. Am OK.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 10-15mg | 20-30mg | 30-45mg | 45mg+ |
| Intravenous | 5mg | 10-15mg | 20mg | 20mg+ |
| Smoked | 10-25mg | 25-35mg | 35-60mg | 60mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 19-45 min | 30-60 min | 2.5-3.5 hrs | 1.5-2 hrs | 3-7 hrs |
| Intravenous | 1-3 min | - | - | - | 1-3 min |
| Smoked | - | - | - | - | 3-7 hrs |
Effect Profile
18 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
8.8
Intense+
9/10
Strong visuals, headspace, auditory effects, and body load
Visual Intensity
×3
10
internal hallucinations
colour enhancement
autonomous entities
drifting
tracers
synaesthesia
+9 more
Headspace Depth
×3
10
conceptual thinking
thought connectivity
recursion
emotion enhancement
perspective alterations
perspective distortions
+5 more
Auditory Effects
×1
10
auditory distortion
auditory enhancement
auditory hallucinations
auditory hallucination
synaesthesia
Body Load / Somatic Effects
×1
10
temperature regulation suppression
nausea
muscle tension
teeth grinding
increased heart rate
Tolerance
Build-up
develops rapidly after a single use
Reset
7โ14 days for baseline
Tolerance Decay
Full tolerance
1h
Half tolerance
10d
Baseline
~14d
Acute tolerance: develops within a single session โ the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Aggregated from 18 Erowid experience reports
Positive Effects 9
Color Enhancement
61.1%
70%
Stimulation
61.1%
70%
Music Enhancement
55.6%
70%
Focus Enhancement
50.0%
70%
Euphoria
44.4%
70%
Introspection
38.9%
70%
Empathy
38.9%
70%
Tactile Enhancement
38.9%
70%
Body High
27.8%
70%
Adverse Effects 5
Confusion
61.1%
70%
Muscle Tension
38.9%
70%
Nausea
27.8%
70%
Anxiety
27.8%
70%
Pupil Dilation
16.7%
70%
Combinations
Cross-Check 4-HO-DET with another substanceTrip Reports
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 8 reports 1 positive 7 neutral visit
Background: -On no prescription drugs and slightly empty stomach -In my backyard at night -Mindset was positive and interested On the last night that my entire friend group could hang out before the first of us left for college we decided to have a tent night in my backyard, which is somewhat of a tradition now.
Alright, first off Iยll give you a little background information. Iยm 20 years old at the time of my first 4-HO-DET experience and I have a decent amount of experience with psychoactives and hallucinogens.
T0:00- Dosed T0:15- Onset. I am beginning to shake a good bit. Mentally it feels like a sort of soft psychedelic drowsiness with pangs of some deep primal anxiety. T0:30- I am lying on my bed and amidst its immaculate comfort, the drowsiness has turned into a full and gentle sedation.
Intro: Had planned my day out earlier in the week, very clean house, organized spaces, intentions set and a ready mind. Not trying to 'control' things too much but preparing. A perfect day outside in the wild west here, 70 degrees, sunny and mild wind. 9:50am I took 35mg (between 35mg and 40mg, scale problems).
Material - 18 mg ethocin (4-HO-DET) in a gelcap, admistered rectally. Setting - My apartment, various places around the city. Purpose - Entertainment and exploration. -0:30 - Use the bathroom to clear myself out for rectal administration.
Ethocin for some reason always interested me, and a year ago when I passed up the chance to acquire some, I was very saddened. Recently, though, I was able to get my hands on a gram for experimentation. This particular venture was between my significant other of several years, and myself in our home.
I consider myself to be a highly experienced psychonaut, I've had hundreds of experiences with 2C-I, 2C-E, 5-MeO-AMT, 5-MeO-MiPT, 5-MeO-DMT, DOC, 4-AcO-DMT, 4-AcO-MiPT, mushrooms, ayahuasca, LSA, amanita mushrooms, yopo, and I was looking forward to this new tool to add to the bag.
Bluelight Reference Guide
Tryptamines The Big & Dandy 4-HO-DET Thread
4-ho-DET has produced some decent experiences. I could have gotten the same experience, with a more chemical feel from MDA. I'd compare it more to MDA than mushrooms... but not as rushy by far.
Read full thread on Bluelight โPiHKAL / TiHKAL
TiHKAL #16: 4-HO-DET
“This was in a gelatin capsule and it came on from a half hour to the three-quarter hour point like gang-busters. Time really slowed down, with sparkly-ness, interesting, and yet there was a touch of sadness. The intense visuals held the scene, and there was the compulsion to talk and to interact and to share stuff, but the erotic was not to be found. I slept OK but there was something uncomfortable at a deep level. Am OK.”
4-HO-DET's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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